首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   10158篇
  免费   683篇
  国内免费   101篇
耳鼻咽喉   60篇
儿科学   626篇
妇产科学   151篇
基础医学   868篇
口腔科学   159篇
临床医学   2618篇
内科学   1020篇
皮肤病学   132篇
神经病学   1130篇
特种医学   186篇
外科学   911篇
综合类   832篇
一般理论   1篇
预防医学   1311篇
眼科学   56篇
药学   574篇
  4篇
中国医学   169篇
肿瘤学   134篇
  2023年   359篇
  2022年   407篇
  2021年   613篇
  2020年   570篇
  2019年   535篇
  2018年   493篇
  2017年   416篇
  2016年   298篇
  2015年   320篇
  2014年   780篇
  2013年   685篇
  2012年   570篇
  2011年   660篇
  2010年   503篇
  2009年   425篇
  2008年   437篇
  2007年   370篇
  2006年   306篇
  2005年   295篇
  2004年   207篇
  2003年   171篇
  2002年   121篇
  2001年   115篇
  2000年   102篇
  1999年   68篇
  1998年   59篇
  1997年   53篇
  1996年   53篇
  1995年   63篇
  1994年   62篇
  1993年   52篇
  1992年   53篇
  1991年   64篇
  1990年   51篇
  1989年   42篇
  1988年   27篇
  1987年   31篇
  1986年   33篇
  1985年   74篇
  1984年   55篇
  1983年   77篇
  1982年   73篇
  1981年   41篇
  1980年   39篇
  1979年   33篇
  1978年   13篇
  1977年   15篇
  1976年   24篇
  1974年   8篇
  1973年   7篇
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
徐素琴  向邱 《全科护理》2022,20(1):73-76
目的:探讨项目管理在降低呼吸重症监护室(RICU)环境物品表面多重耐药菌检出率中的应用效果。方法:采用目的抽样方法,选取医院呼吸与危重症医学科RICU 17张编制床位、32处高频接触环境物品表面及42名工作人员为观察对象。2019年1月—2019年3月实施RICU常规管理,2019年4月—2019年6月实施项目管理。比较项目管理前后RICU各类别工作人员手卫生依从率、RICU环境物品表面清洁合格率及多重耐药菌检出率。结果:在项目管理后RICU各类别工作人员手卫生依从率均高于项目管理前(P<0.05);项目管理后RICU环境物品表面清洁合格率较项目管理前升高(P<0.05);项目管理后多重耐药菌(MDRO)病人床单位及病区办公区域环境物体表面的耐甲氧西林金黄色葡萄球菌(MRSA)和耐碳青霉烯鲍曼不动杆菌(CRAB)检出率均较项目管理前降低(P<0.05)。结论:项目管理可有效提高RICU各类别工作人员手卫生依从性及环境物品表面清洁合格率,降低RICU环境物品表面多重耐药菌检出率。  相似文献   
2.
《Australian critical care》2022,35(4):362-368
BackgroundThere are limited published data on physical activity of survivors of critical illness engaged in rehabilitation in hospital, despite it plausibly influencing outcome.ObjectiveThe aims of this study were to measure physical activity of patients with critical illness engaged in rehabilitation in the intensive care unit (ICU) and on the acute ward and report discharge destination, muscle strength, and functional outcomes.MethodsThis was a single-centre, prospective observational study. Adults with critical illness, who received ≥48 h of invasive mechanical ventilation, and who were awake and able to participate in rehabilitation were eligible. To record physical activity, participants wore BodyMedia SenseWear Armbands (BodyMedia Incorporated, USA), during daylight hours, from enrolment until hospital discharge or day 14 of ward stay (whichever occurred first). The primary outcome was time (minutes) spent performing physical activity at an intensity of greater than 1.5 Metabolic Equivalent Tasks. Secondary outcomes included discharge destination, muscle strength, and physical function.ResultsWe collected 807 days of physical activity data (363 days ICU, 424 days ward) from 59 participants. Mean (standard deviation) duration of daily physical activity increased from the ICU, 17.8 (22.8) minutes, to the ward, 52.8 (51.2) minutes (mean difference [95% confidence interval] = 35 [23.8–46.1] minutes, P < .001). High levels of activity in the ICU were associated with higher levels of activity on the ward (r = .728), n = 48, P < .001.ConclusionsPatients recovering from critical illness spend less than 5% of the day being physically active throughout hospital admission, even when receiving rehabilitation. Physical activity increased after discharge from intensive care, but had no relationship with discharge destination. Only the absence of ICU-acquired weakness on awakening was associated with discharge directly home from the acute hospital. Future studies could target early identification of ICU-acquired weakness and the preservation of muscle strength to improve discharge outcomes.  相似文献   
3.
4.
《Pancreatology》2022,22(5):665-670
Background and objectivesHyperlipasemia is highly prevalent among coronavirus disease 2019 (COVID-19) patients. The aim of this study was to assess the effect of lipase activity, measured at the time of admission, on the clinical course and mortality in COVID-19 patients.MethodsThe population of this study comprised 12,139 patients who were hospitalized due to COVID-19 between June 2020 and June 2021 in a pandemic hospital. Of these, 8819 patients were excluded from the study due to missing data, four patients were excluded due to a diagnosis of acute pancreatitis (according to the revised Atlanta criteria), and 72 patients were excluded due to alcohol use or having a history of chronic pancreatitis. The final study sample consisted of the remaining 3244 COVID-19 patients. Laboratory results, intensive care unit (ICU) follow-up periods, the need for mechanical ventilation, and mortality rates were compared between the normal lipase activity and high lipase activity groups.ResultsThere were 968 (29.8%) patients with high lipase activity at the time of admission. The rate of ICU admission was 36.1% vs. 9.9% (p < 0.001), mechanical ventilation requirement rates were 33.7% vs. 8.3% (p < 0.001), and mortality rates were as 24.6% vs. 6.4% (p < 0.001) in the high lipase activity group compared to the normal lipase activity group. Multivariate regression analysis revealed that high lipase activity was an independent factor in predicting mortality in hospitalized COVID-19 patients (odds ratio [OR]: 3.191, p < 0.001).ConclusionElevated lipase activity without acute pancreatitis at the time of admission in COVID-19 patients was determined as an independent predictor of poor prognosis.  相似文献   
5.
6.
7.
8.

糖尿病视网膜病变(DR)作为常见的糖尿病并发症之一,是导致失明的主要原因。传统上,DR主要被认为是一种微血管疾病,随着研究的进展,目前认为神经-胶质-血管单元(NVU)破坏及其耦联机制(coupling)失衡在DR发病的早期起到了关键作用。了解NVU的细胞和分子基础,以及糖尿病如何改变正常的细胞通讯和破坏细胞环境,对DR的早期防治具有重要的意义。本文总结视网膜NVU及其参与DR发病分子机制,基于视网膜NVU修复的DR治疗,并对DR未来发展前景及问题进行探讨。  相似文献   

9.
ObjectivesTo evaluate the long-term effectiveness of an action research intervention aimed at improving hand hygiene in an intensive care unit of a public hospital in Italy.MethodsAn observational, prospective before-after study was carried out. Compliance with hand hygiene was estimated by measuring the utilization of hand hygiene products before the intervention and four years after the end of the project. Products used were the following: detergent liquid soap, antiseptic liquid soap and alcohol-based hand gel. Endpoints were quantity consumed (in grams) for each product category. Quantitative consumptions per workshift were compared.ResultsIn 2017 the median consumption of antiseptic liquid soap and alcohol-based hand gel per workshift was significantly higher than in 2012 (111.5 g vs 72.5 g, p = 0.014, and 18.0 g vs 5.0 g, p < 0.001). Odds in favour of a higher value in 2017 were 1.99:1 (CI95%: 1.19:1 to 3.73:1) for antiseptic solution, and 5.39:1 (CI95%: 3.09:1 to 13.61:1) for antiseptic gel. Covariates were not associated with consumption of products, and this made it possible to compare the measurements in the two data collections.ConclusionsResults of this study support the long-term effectiveness of the action research intervention to improve practices of hand hygiene in an intensive care setting.  相似文献   
10.
PurposeTo verify whether there is an association between the Nursing Activities Score (NAS) on the day of discharge from the intensive care unit and readmission..Materials and methodsA retrospective cohort study of all patients admitted to the intensive care unit of Hospital Ernesto Dornelles, Porto Alegre, Brazil, who were discharged to the ward from October 2018 to December 2019. We collected demographic and clinical variables of the patients and the Nursing Activities Scoreon the day of discharge. Patients were followed up until the day of hospital discharge or death.ResultsWe included 1045 patients in the final sample. One hundred eighty-eight (18.0%) patients were readmitted, in addition there were two (0.2%) unexpected deaths that occurred in the ward. The median NAS was 59.9 (50.9–67.3), which was higher in the bivariate analysis in patients who were readmitted (64.0, 55.7–71.4) than in patients who were not readmitted (58.7, 49.7–66.1) (p < 0.001). Patients with a Nursing Activities Score  ≥ 60.0 and < 60.0 had rates of readmission of 23.4% and 12.7%, respectively (p < 0.001). After multivariable adjustment, the Nursing Activities Score at discharge maintained an association with readmission. In addition, in the Cox regression, the Nursing Activities Score as a dichotomous variable was independently associated with readmission (adjusted HR 1.560; CI 1.146–2.125; p = 0.005).ConclusionsWe found that the nursing workload, assessed by the Nursing Activities Score at the time of discharge from the intensive care unit, was associated with risk of readmission..  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号