全文获取类型
收费全文 | 546篇 |
免费 | 66篇 |
国内免费 | 50篇 |
专业分类
儿科学 | 2篇 |
妇产科学 | 22篇 |
基础医学 | 33篇 |
口腔科学 | 4篇 |
临床医学 | 126篇 |
内科学 | 178篇 |
皮肤病学 | 1篇 |
神经病学 | 3篇 |
特种医学 | 17篇 |
外科学 | 70篇 |
综合类 | 114篇 |
预防医学 | 15篇 |
药学 | 22篇 |
2篇 | |
中国医学 | 2篇 |
肿瘤学 | 51篇 |
出版年
2023年 | 19篇 |
2022年 | 33篇 |
2021年 | 71篇 |
2020年 | 72篇 |
2019年 | 27篇 |
2018年 | 22篇 |
2017年 | 19篇 |
2016年 | 39篇 |
2015年 | 33篇 |
2014年 | 46篇 |
2013年 | 42篇 |
2012年 | 38篇 |
2011年 | 40篇 |
2010年 | 35篇 |
2009年 | 25篇 |
2008年 | 17篇 |
2007年 | 13篇 |
2006年 | 12篇 |
2005年 | 8篇 |
2004年 | 10篇 |
2003年 | 4篇 |
2002年 | 7篇 |
2001年 | 5篇 |
2000年 | 7篇 |
1999年 | 3篇 |
1998年 | 3篇 |
1997年 | 1篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1991年 | 2篇 |
排序方式: 共有662条查询结果,搜索用时 93 毫秒
1.
目的:研究超声引导下腰方肌阻滞联合丙泊酚麻醉在腹腔镜结直肠癌根治术中的应用价值。方法:选取90例择期进行腹腔镜结直肠癌根治术患者作为研究对象,随机分为观察组和对照组,各45例。对照组采用传统腰麻联合丙泊酚麻醉,观察组采用超声引导下腰方肌阻滞联合丙泊酚麻醉,比较两组患者术中(麻醉后5、15、30、60 min)收缩压(SBP)、舒张压(DBP)、心率(HR)和术后不同时间段的疼痛评分(VAS评分),以及加用镇痛药情况和肠道恢复排气时间和术后48 h内不良反应发生情况。结果:两组患者SBP、DBP、HR组间、不同时间点及交互差异均有统计学意义(P<0.05),且观察组麻醉后上述指标波动较对照组小(P<0.05);麻醉前,两组患者皮质醇、肾上腺素水平无显著差异(P>0.05),麻醉后各时间点观察组患者上述指标水平均显著低于对照组(P<0.05);两组患者VAS评分组间、不同时间点及交互差异均有统计学意义(P<0.05),且观察组术后各时间点VAS评分均显著低于对照组(P<0.05);观察组不良反应发生率显著低于对照组(8.89% vs 24.44%, P<0.05);观察组患者加用镇痛药的人数、剂量和肠道恢复排气时间均显著少于对照组(P<0.05)。结论:超声引导下腰方肌阻滞联合丙泊酚麻醉在腹腔镜结直肠癌手术中具有良好、稳定的麻醉效果,可有效缓解患者疼痛,减少术后不良反应发生。 相似文献
2.
Yung-Tsan Wu MD Si-Ru Chen MD Tsung-Ying Li MD Tsung-Yen Ho MD Yu-Ping Shen MD Chia-Kuang Tsai MD PhD Liang-Cheng Chen MD MS 《Muscle & nerve》2019,59(2):174-180
Introduction: In this study we explored the efficacy of nerve hydrodissection for mild-to-moderate carpal tunnel syndrome (CTS). Methods: Thirty-four participants were randomly assigned to an intervention group or a control group. One 5-ml dose of normal saline was injected into the intracarpal and subcutaneous regions in subjects of both groups, respectively. The primary outcome measure was the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) score. Secondary outcomes were cross-sectional area of the median nerve and electrophysiological studies. Assessments were performed before the injection and at 1, 2, 3, and 6 months postintervention. Results: Compared with the control group, the intervention group showed significantly greater improvement at the second and third posttreatment months according to BCTQ severity score and at all time-points for cross-sectional area of the median nerve (P < 0.01). Discussion: Our study demonstrates the therapeutic effects of nerve hydrodissection for mild-to-moderate CTS. Muscle Nerve 59 :174–180, 2019 相似文献
3.
目的 评价三维可视化辅助经皮微波消融治疗复发性肝癌的临床效果。方法 选择2017-12-01至2019-06-01中国人民解放军总医院介入超声科连续收治的经皮微波消融的84例复发性肝癌病人,根据是否进行三维可视化评估分为三维重建组(30例,49个病灶)和常规组(54例,111个病灶)。比较两组病人治疗相关指标及预后情况。用三维可视化软件计算术前全肝体积、肿瘤体积、预计消融体积、术后全肝体积、消融体积,并对比术前规划消融体积与术后实际消融体积。结果 所有病人均完成经皮微波消融治疗,肿瘤最大径为(4.3±1.0)cm。随访时间为10(2~19)个月。三维重建组和常规组严重并发症发生率(6.7% vs. 9.3%)、总存活率(100% vs. 94.4%)、肝内复发率(8.2% vs. 12.6%)及局部复发率(6.1% vs. 10.8%)差异无统计学意义(P>0.05)。三维重建组病人术前规划体积和消融体积差异无统计学意义(P=0.616),消融后剩余肝体积与标准肝体积的比值为98.0%±25.6%。两组病人微波消融前后的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素、胆碱酯酶差异无统计学意义(P>0.05)。结论 三维可视化辅助经皮微波消融在复发性肝癌的精准治疗中有重要的价值。 相似文献
4.
Background
Regional anaesthesia for upper limb surgery is routinely performed with brachial plexus blocks. A retroclavicular brachial plexus block has recently been described, but has not been adequately compared with another approach. This randomised controlled single-blinded trial tested the hypothesis that the retroclavicular approach, when compared with the supraclavicular approach, would increase the success rate.Methods
One hundred and twenty ASA physical status 1–3 patients undergoing distal upper limb surgery were randomised to receive an ultrasound-guided retroclavicular or supraclavicular brachial plexus block with 30 mL of a 1:1 mixture of mepivacaine 1% and ropivacaine 0.5%, using a single-injection technique without needle tip repositioning. The primary outcome was block success rate 30 min after local anaesthetic injection, defined as a composite score of 14 of 16 points, inclusive of sensory and motor components. Secondary outcomes included needling time, time to first opioid request, oxycodone consumption, and pain scores (numeric rating scale, 0–10) at 24 h postoperatively.Results
Success rates were 98.3% [95% confidence interval (CI): 90.8%, 99.9%] and 98.3% [95% CI: 90.9%, 99.9%] in the supraclavicular and retroclavicular groups, respectively (P=0.99). The mean needling time was reduced in the supraclavicular group [supraclavicular: 5.0 (95% CI: 4.7, 5.4) min; retroclavicular: 6.0 (95% CI: 5.4, 6.6) min; P=0.006]. The mean time to first opioid request was similar between groups [supraclavicular: 439 (95% CI: 399, 479) min; retroclavicular: 447 (95% CI: 397, 498) min; P=0.19] as were oxycodone consumption [supraclavicular: 10.0 (95% CI: 6.5, 13.5 mg; retroclavicular: 7.9 (95% CI: 4.8, 11.0) mg; P=0.80] and pain scores at 24 h postoperatively [supraclavicular: 1.2 (95% CI: 2.1, 2.7); retroclavicular: 1.5 (95% CI: 1.6, 2.4); P=0.09].Conclusions
Ultrasound-guided retroclavicular and supraclavicular brachial plexus blocks share identical success rates, while providing similar pain relief. Reduced needling time in the supraclavicular approach is not clinically relevant.Clinical trial registration
NCT02641613. 相似文献5.
6.
7.
Nicolás García MD Julio Rosales MD Cristóbal Greene MD Guillermo Droppelmann MSc PhD Marco A. Verdugo MD 《Journal of ultrasound in medicine》2020,39(1):165-168
The aim of this study was to describe a perineural ultrasound-guided infiltration technique for management of radial tunnel syndrome and to report its preliminary results in 54 patients. A mixture of a saline solution, a local anesthetic, and a corticosteroid solution was infiltrated in the perineural region at the arcade of Frohse. Pain was reported in 100% of patients before the procedure versus 1.9% after the procedure. Scratch collapse and Cozen test results were positive in 98.1% and 66.7% of patients before infiltration, respectively, versus 5.6% and 9.2% after infiltration. All variables had statistically significant differences between preprocedure and postprocedure evaluations (P < .01). 相似文献
8.
9.
Rishi Pawa Troy Pleasant Chloe Tom Swati Pawa 《World journal of gastrointestinal endoscopy》2021,13(8):302-318
Endoscopic retrograde cholangiopancreatography (ERCP) is the mainstay procedure of choice for management of obstructive biliary disease. While ERCP is widely performed with high success rates, the procedure is not feasible in every patient such as cases of non-accessible papilla. In the setting of unsuccessful ERCP, endoscopic ultrasound-guided biliary drainage (EUS-BD) has become a promising alternative to surgical bypass and percutaneous biliary drainage (PTBD). A variety of different forms of EUS-BD have been described, allowing for both intrahepatic and extrahepatic approaches. Recent studies have reported high success rates utilizing EUS-BD for both transpapillary and transluminal drainage, with fewer adverse events when compared to PTBD. Advancements in novel technologies designed specifically for EUS-BD have led to increased success rates as well as improved safety profile for the procedure. The techniques of EUS-BD are yet to be fully standardized and are currently performed by highly trained advanced endoscopists. The aim of our review is to highlight the different EUS-guided interventions for achieving biliary drainage and to both assess the progress that has been made in the field as well as consider what the future may hold. 相似文献
10.
Peter Marhofer Malachy Columb Phil M. Hopkins Manfred Greher Daniela Marhofer Max R. Levi Bienzle Markus Zeitlinger 《British journal of anaesthesia》2019,122(4):525-531