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1.
肥胖的高血压病患者中医体质分类与胰岛素抵抗的关系   总被引:14,自引:1,他引:13  
[目的]探讨中医的体质分型与胰岛素抵抗的关系。[方法]按体质分型标准将一组肥胖的高血压病患者,分为阳亢质组(28例)和痰湿质组(34例),进行葡萄糖耐量试验(OGTT)和胰岛素释放试验(InRT)检测,采用胰岛素敏感指数(ISI)、胰岛素抵抗指标(Homa-IR)和胰岛β细胞功能指数(MBCI)等指标做比较分析。[结果]1.痰湿质组高血压病人胰岛素的水平高于阳亢质组高血压病人,尤其是空腹时和30分钟时的胰岛素值分别为1.03±0.24mU/L、1.93±0.22mU/L和0.85±0.17mU/L、1.72±0.38mU/L,差异明显且有统计学意义(P=0.002、0.01)。2.痰湿质组和阳亢质组2组ISI分别为-1.77±0.26、-1.60±0.17,(P=0.004);Homa-IR分别为0.41±0.26、0.25±0.17,(P=0.005);MBCI分别为16.92±14.89、8.83±6.76,(P=0.012)。[结论]痰湿质组高血压患者为维持血糖在正常水平,胰岛β细胞的功能是亢进的,胰岛素的分泌也明显增加,与阳亢质组相比,胰岛素的敏感性下降,胰岛素抵抗现象严重。痰湿质的高血压患者心血管的易损性可能比阳亢质组更明显。  相似文献
2.
脂肪肝超声诊断与血脂、血糖和肥胖的相关性分析   总被引:10,自引:0,他引:10  
目的:探讨脂肪肝的超声诊断及脂肪肝与三酰甘油(TG),总胆固醇,血糖,肥胖的关系.方法:2005-08/2006-03门诊健康体检1122名脂肪肝360例和正常肝762例进行TG,总胆固醇(TC),血糖(FPG),身高,体质量测定,对结果进行分析比较.结果:脂肪肝患病率男性(46.3%)高于女性(11.2%),差异有统计学意义(P<0.05);51~60年龄组患病率最高(53.6%),各年龄组的患病率经χ2检验,差异有统计学意义(P<0.05);脂肪肝组TG,总胆固醇,血糖,体重指数(BMI)4项指标均高于对照组(P<0.05),并且脂肪肝的程度越重,血脂异常率越大(P<0.05),血糖异常率也越大(P<0.05).结论:脂肪肝与血脂,血糖和肥胖有关. 此外,超声对脂肪肝的诊断有较高的临床实用价值.  相似文献
3.
Background Vaspin is a newly-identified adipocytokine related to obesity and insulin sensitivity. However, its pathophysiologic role in humans remains largely unknown. The aim of our study was to investigate the relationship between serum vaspin level and glucose metabolism or obesity in Chinese adults. Methods A total of 123 subjects, including 84 subjects with normal glucose tolerance (NGT) and 39 subjects with diabetes, were enrolled in this study. Anthropometric parameters, abdominal fat areas, plasma glucose concentration, serum insulin, lipids, and vaspin level were measured in each participant. Results Serum vaspin concentration was significantly higher in diabetic patients than that in NGT subjects (592 (438-695) pg/ml vs 380 (294-517) pg/ml, P=0.020) in women. In all participants, age, fasting plasma glucose concentration (FPG), 2-hour post-load plasma glucose (PG2h), hemoglobin Alc (HbAlc) and high-density lipoprotein cholesterol (HDL-c) significantly increased from the lower tertile to the higher tertile of vaspin. Univariate linear regression analyses revealed that vaspin level was only positively correlated with age (β=0.340, P=0.002) in NGT subjects. And vaspin was positively associated with FPG (β=0.365, P=0.023), PG2h (β=0.526, P=0.001), HbAlc (β=0.388, P=0.016), and HDL-c (β=0.353, P=0.027), while negatively with homeostasis model assessment of beta cell function (HOMA-β) (β=-0.361, P=-0.024) in diabetic patients. In stepwise multivariate regression analyses, age was independently associated with circulating vaspin in NGT subjects, whereas PG2h was an independent predictor of vaspin in diabetic patients. In addition, there was no significant difference of serum vaspin level between men and women. And no significant correlations between vaspin and body fat indexes were detected. Conclusions Serum vaspin level is higher in diabetic patients than that in NGT subjects in women. Age predicts serum vaspin level in NGT subjects, while PG2h is independently associated with vaspin in diabetic patients.  相似文献
4.
益气散聚方治疗代谢综合征肥胖高危人群的临床研究   总被引:8,自引:2,他引:6  
目的:观察益气散聚方在“聚证”学说指导下治疗代谢综合征肥胖高危人群的临床疗效。方法:以30名健康志愿者为参照,将45名中心性肥胖患者随机分为中药组和安慰剂组,分别予益气散聚方和安慰剂治疗10周,观察治疗前后一般状况、胰岛素抵抗、相关炎症因子及纤溶系统因子变化。结果:与对照组相比,肥胖人群胰岛素抵抗指数、C反应蛋白、游离脂肪酸、纤溶酶原激活物抑制物1均有升高,组织纤溶酶原激活物下降;治疗后,中药组体质量指数、腰围、腰臀比及胰岛素抵抗指数、C反应蛋白、游离脂肪酸、纤溶酶原激活物抑制物1均明显改善,与安慰剂组相比,差异有统计学意义。结论:益气散聚方可明显降低代谢综合征肥胖高危人群肥胖和胰岛素抵抗程度,并能改善炎症状态、纤溶系统功能,减轻致动脉粥样硬化的危险性。  相似文献
5.
2518例肥胖2型糖尿病中医证型分类研究   总被引:6,自引:0,他引:6  
目的:研究肥胖2型糖尿病(T2DM)的中医症状分布、证型特征。方法:采集门诊病例信息,按类别分析,确定主要证型。结果:2518例肥胖T2DM患者中肝胃郁热证1332例,占52.9%;胃肠实热证368例,占14.6%;气滞痰阻证171例,占6.8%;脾虚痰湿证219例,占8.7%;其他证型428例,占17%。2518例肥胖T2DM患者属中满内热者1871例,占74.3%,其中肝胃郁热证1332例,占71.2%;非中满内热者647例,占25.7%。结论:随着年龄的增长及病程的延长,实证所占比率逐渐下降,虚证或虚实夹杂证所占比率则呈逐渐上升趋势。  相似文献
6.
Adipocytokines and breast cancer risk   总被引:6,自引:0,他引:6       下载免费PDF全文
Hou WK  Xu YX  Yu T  Zhang L  Zhang WW  Fu CL  Sun Y  Wu Q  Chen L 《中华医学杂志(英文版)》2007,120(18):1592-1596
Background Many researches suggested that obesity increased the risk of breast cancer, but the mechanism was currently unknown. Adipocytokines might mediate the relationship. Our study was aimed to investigate the relationship between serum levels of resistin, adiponectin and leptin and the onset, invasion and metastasis of breast cancer. Methods Blood samples were collected from 80 newly diagnosed, histologically confirmed breast cancer patients and 50 age-matched healthy controls. Serum levels of resistin, adiponectin and leptin were determined by enzyme-linked immunosorbent assays (ELISA); fasting blood glucose (FBG), lipids, body mass index (BMI), and waist circumference (WC) were assayed simultaneously.Results Serum levels of adiponectin ((8.60±2.92) mg/L vs (10.37±2.81) mg/L, P=0.001) and HDL-c were significantly decreased in breast cancer patients in comparison to controls. Serum levels of resistin ((26.35±5.36) μg/L vs (23.32±4.75) μg/L, P=0.000), leptin ((1.35±0.42) μg/L vs (1.06±0.39) μg/L, P=0.003), FBG and triglyceride (TG) in breast cancer patients were increased in contrast to controls, respectively. However, we did not find the significant difference of the serum levels of resistin, adiponectin and leptin between premenopausal breast cancer patients and healthy controls (P=0.091, 0.109 and 0.084, respectively). The serum levels of resistin, adiponectin and leptin were significantly different between patients with lymph node metastasis (LNM) and those without LNM (P=0.001, 0.000 and 0.006, respectively). The stepwise regression analysis indicated that the tumor size had the close correlation with leptin (R(2)=0.414, P=0.000) and FBG (R(2)=0.602, P=0.000). Logistic regression analysis showed that reduced serum levels of adiponectin (OR: 0.805; 95%CI: 0.704–0.921; P=0.001), HDL (OR: 0.087; 95%CI: 0.011–0.691, P=0.021), elevated leptin (OR: 2.235; 95%CI:1.898–4.526; P=0.004) and resistin (OR: 1.335; 95%CI: 1.114–2.354; P=0.012) increased the risk for breast cancer; Reduced serum levels of adiponectin (OR: 0.742; 95%CI: 0.504–0.921; P=0.003) and elevated leptin (OR: 2.134; 95%CI:1.725–3.921; P= 0.001) were associated with lymph node metastasis of breast cancer. Conclusions The decreased serum adiponectin levels and increased serum resistin and leptin levels are risk factors of breast cancer. The low serum adiponectin levels and high serum leptin levels are independent risk factors for metastasis of cancer. The association between obesity and breast cancer risk might be explained by adipocytokines.  相似文献
7.
山东沿海居民体质量超标和肥胖的流行病学调查   总被引:5,自引:3,他引:2  
目的明确山东沿海18周岁以上居民体质量超标和肥胖的患病情况。方法采用随机、分层、整群抽样的方法 ,采用WHO诊断标准,调查山东沿海城市青岛、烟台、威海、日照、东营长住居民5 732人体质量超标和肥胖的患病情况。结果山东沿海居民总的体质量超标患病率为38.03%,其中男性为36.62%,女性为39.08%;总的肥胖患病率为8.06%,其中男性为6.34%,女性为9.34%。男女之间肥胖患病率比较,差异有统计学意义(χ2=16.97,P<0.01);而男女之间体质量超标的患病率比较,差异无统计学意义(χ2=3.60,P>0.05)。结论山东沿海居民体质量超标和肥胖的患病率近年来均有明显增加,应尽早采取必要措施开展体质量超标和肥胖的防治研究。  相似文献
8.
腹型肥胖的类型与代谢综合征发生的风险   总被引:5,自引:0,他引:5  
He HB  Zhao ZG  Pu YF  Chen J  Ni YX  Zhong J  Liu HY  Li YS  Yan ZC  Liu DY  Zhu ZM 《中华医学杂志》2008,88(18):1251-1254
目的 探讨不同的腹型肥胖类型与代谢综合征(MS)发生风险的关系.方法 选择至少有一项心血管代谢危险因素的患者846例,应用CT测量腹壁和腹内脂肪面积,同时测量腰围、血压、空腹血糖、空腹胰岛素和血脂谱,按照是否腰围超标和合并内脏脂肪型肥胖(VFO)分为4个亚组:非肥胖组,隐性VFO组,假性VFO组和VFO组,比较不同腹型肥胖类型患者的MS风险.结果 (1)男性隐性VFO 51例(10.9%)显著高于女性18例(4.8%).(2)男性隐性VFO组MS罹患率22例(43.1%)显著高于非肥胖组47例(25.0%),低于假性VFO组37例(78.7%)和VFO组163例(88.6%).假性VFO组MS罹患率显著高于非肥胖组和隐性VFO组.(3)女性隐性VFO组MS6例(33.3%)与非肥胖组48例(31.2%)差异无统计学意义,但显著低于假性VFO组74例(78.7%)和VFO组100例(90.9%).假性VFO组的MS罹患率高于非肥胖组和隐性VFO组,与VFO组差异无统计学意义.(4)腰围增加和腹内脂肪堆积是发生MS的独立危险因素[OR 1.13(1.10~1.17),1.01(1.01~1.02),P<0.01].结论 不同腹型肥胖类型对MS危险有显著影响,隐性VFO和假性VFO患者同样有较高的心血管代谢风险.  相似文献
9.
体重指数和腰围用于肥胖的营养评定   总被引:4,自引:1,他引:3  
本文介绍了体重指数和腰围在肥胖营养评定中的价值和局限性,并强调将二者结合用于评定肥胖的重要性.  相似文献
10.
营养性肥胖大鼠模型的建立及评价   总被引:4,自引:0,他引:4       下载免费PDF全文
目的高脂饲料喂养诱导营养性肥胖大鼠模型的建立及评价。方法将45只成年sD大鼠随机分为正常模型组(n=40)和对照组(n=5),分别给与基础饲料和高脂饲料喂养8周,检测大鼠体重、体长、体重指数(bodymassindex,BMI)、血糖及总胆固醇(cholesterol,CHO)、甘油三酯(triglyceride,TG)、高密度脂蛋白(highdensity lipoprotein—cholesterol,HDL—C)及低密度脂蛋白(low density lipoprotein—cholesterol,LDL-C)。结果通过高脂饲料喂养后,模型组大鼠体重、BMI与对照组比较差别均有统计学意义(P〈0.05,P〈0.01);其总胆固醇及LDL—C明显高于对照组(P〈0.05,P〈0.01),HDL—C则明显低于对照组(P〈0.01),造模过程中,甘油三酯两组差别无统计学意义;模型组大鼠存在糖耐量异常。结论通过高脂饲料喂养可诱导出符合或贴近临床的营养性肥胖大鼠模型。  相似文献
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