240家大型公立医院院训特点分析

医院精神是医院文化的内核，表现在文字层面就是医院的院训，是医院员工核心价值观的集中体现。笔者调查分析了国内240家三甲医院，发现当代医院院训构成显现出追求对偶整饬、词约义丰、音韵和谐的美感，以及对儒家仁爱诚信思想的继承等特点，但也存在政治化倾向、缺乏独创性、亲和力和服务意识等问题。医院精神的凝炼应当走下圣坛，绕开政治化、功利化、趋同化的漩涡，努力实现个性化发展及与患方的和谐交融。     

Melatonin receptor ligands: A pharmaco-chemical perspective

Melatonin MT₁ and MT₂ receptor ligands have been vigorously explored for the last 4 decades. Inspection of approximately 80 publications in the field revealed that most melatonergic ligands were structural analogues of melatonin combining three essential features of the parent compound: an aromatic ring bearing a methoxy group and an amide side chain in a relative arrangement similar to that present in melatonin. While several series of MT₂-selective agents—agonists, antagonists, or partial agonists—were reported, the field was lacking MT₁-selective agents. Herein, we describe various approaches toward the development of melatonergic ligands, keeping in mind that most of the molecules/pharmacophores obtained were essentially melatonin copies, even though diverse tri- or tetra-cyclic compounds were explored. In addition to lack of structural diversity, only few studies examined the activity of the reported melatonergic ligands in vivo. Moreover, an extensive pharmacological characterization including biopharmaceutical stability, pharmacokinetic properties, specificity toward other major receptors to name a few remained scarce. For example, many of the antagonists described were not stable in vivo, were not selective for the melatonin receptor subtype of interest, and were not fully characterized from a pharmacological standpoint. Indeed, virtual screening of large compound libraries has led to the recent discovery of potent and selective melatonin receptor agonists and partial agonists of new chemotypes. Having said this, the melatonergic field is still lacking subtype-selective melatonin receptor antagonists “active” in vivo, which are critical to our understanding of melatonin and melatonin receptors’ role in basic physiology and disease.     

在大学生中开展座右铭教育的探索和实践

为全面提高大学生综合素质,不断创新大学生教育和管理模式,结合学生工作特点,我们在大学生中倡议并开展了设立座右铭的教育活动,在创新校园文化建设方面做了有益尝试。通过实践,我们认为在大学生中开展铭牌活动,开展座右铭教育,不失为思想政治教育的有效方法之一,同时也是先进文化进课堂(宿舍)的一种补充形式,为校园文化建设增添了亮丽的色彩,丰富了校园文化建设的内涵,拓展了思想政治教育的渠道,对帮助大学生树立正确的人生观价值观、促进大学生奋发成才、提高综合素质具有重要的意义。     

综合性大学与其附属医院的文化融合与重构

通过对国内含医科综合性大学及独立设置医学院校的校训与其附属医院院训进行比较,了解当今国内相关大学与其附属医院的文化差异。特别是在部分医学院校并入综合性大学的大背景下,从文化层面,研究新组建综合性大学与原医学院校附属医院的文化融合和重构过程,以期探索出一条有效的文化融合和重构途径。     

在大学生中开展座右铭教育的探索和实践

为全面提高大学生综合素质,不断创新大学生教育和管理模式,结合学生工作特点,我们在大学生中倡议并开展了设立座右铭的教育活动,在创新校园文化建设方面做了有益尝试。通过实践,我们认为在大学生中开展铭牌活动,开展座右铭教育,不失为思想政治教育的有效方法之一,同时也是先进文化进课堂（宿舍）的一种补充形式,为校园文化建设增添了亮丽的色彩,丰富了校园文化建设的内涵,拓展了思想政治教育的渠道,对帮助大学生树立正确的人生观价值观、促进大学生奋发成才、提高综合素质具有重要的意义。