全文获取类型
收费全文 | 8151篇 |
免费 | 848篇 |
国内免费 | 249篇 |
专业分类
耳鼻咽喉 | 48篇 |
儿科学 | 217篇 |
妇产科学 | 198篇 |
基础医学 | 1430篇 |
口腔科学 | 184篇 |
临床医学 | 501篇 |
内科学 | 982篇 |
皮肤病学 | 117篇 |
神经病学 | 257篇 |
特种医学 | 132篇 |
外国民族医学 | 2篇 |
外科学 | 1532篇 |
综合类 | 1061篇 |
预防医学 | 258篇 |
眼科学 | 52篇 |
药学 | 639篇 |
1篇 | |
中国医学 | 204篇 |
肿瘤学 | 1433篇 |
出版年
2024年 | 6篇 |
2023年 | 73篇 |
2022年 | 127篇 |
2021年 | 246篇 |
2020年 | 353篇 |
2019年 | 413篇 |
2018年 | 344篇 |
2017年 | 377篇 |
2016年 | 300篇 |
2015年 | 350篇 |
2014年 | 505篇 |
2013年 | 496篇 |
2012年 | 390篇 |
2011年 | 527篇 |
2010年 | 464篇 |
2009年 | 399篇 |
2008年 | 384篇 |
2007年 | 437篇 |
2006年 | 396篇 |
2005年 | 370篇 |
2004年 | 370篇 |
2003年 | 292篇 |
2002年 | 243篇 |
2001年 | 212篇 |
2000年 | 182篇 |
1999年 | 174篇 |
1998年 | 109篇 |
1997年 | 89篇 |
1996年 | 74篇 |
1995年 | 78篇 |
1994年 | 52篇 |
1993年 | 48篇 |
1992年 | 30篇 |
1991年 | 17篇 |
1990年 | 24篇 |
1989年 | 16篇 |
1988年 | 27篇 |
1987年 | 12篇 |
1986年 | 12篇 |
1985年 | 26篇 |
1984年 | 32篇 |
1983年 | 28篇 |
1982年 | 31篇 |
1981年 | 16篇 |
1980年 | 24篇 |
1979年 | 21篇 |
1978年 | 13篇 |
1977年 | 7篇 |
1976年 | 8篇 |
1975年 | 8篇 |
排序方式: 共有9248条查询结果,搜索用时 15 毫秒
1.
《Research in social & administrative pharmacy》2022,18(9):3694-3698
In this paper, we argue that understanding and addressing the problem of poor-quality medical products requires a more interdisciplinary approach than has been evident to date. While prospective studies based on rigorous standardized methodologies are the gold standard for measuring the prevalence of poor-quality medical products and understanding their distribution nationally and internationally, they should be complemented by social science research to unpack the complex set of social, economic, and governance factors that underlie these patterns. In the following sections, we discuss specific examples of prospective quality surveys and of social science studies, highlighting the value of cross-sector partnerships in driving high-quality, policy-relevant research in this area. 相似文献
2.
BackgroundFew studies have investigated the impact of web-based physical activity interventions on mental health outcomes. Therefore, this study examined the impact of a web-based personally tailored physical activity intervention on depression, anxiety, stress and quality of life.Methods501 participants were randomised into either a control group or a pooled intervention condition who received a 3-month web-based personally tailored physical activity intervention. Previously, this intervention has demonstrated to improve self-reported physical activity, but not device-measured physical activity. At baseline, 3- and 9-months, depression, anxiety and stress were assessed using the DASS21, and quality of life was assessed using the SF-12V2. General linear mixed models examined differences between groups over time.ResultsMost participants (>80%) reported normal levels of depression, anxiety or stress. Relative to baseline levels, significant reductions of depression, anxiety, stress and the SF12 mental health component were observed in the pooled intervention group at 3 and 9 months. Relative to the control group, significant reductions were observed in the pooled intervention group for depression and stress (3-months only) and anxiety (3- and 9-months), but not quality of life.ConclusionA web-based physical activity intervention can result in positive mental health outcomes, even in the absence of device-measured physical activity improvements. However, these findings need to be confirmed in future studies.Trial registration numberACTRN12615000057583. 相似文献
3.
目的 探讨TRIM23基因对骨肉瘤细胞增殖能力的影响.方法 应用Western blot实验检测TRIM23基因在骨肉瘤细胞中的表达;应用shRNA质粒转染骨肉瘤细胞系U2OS,通过MTT与平板克隆形成实验评估细胞增殖能力;应用Westernblot实验检测U2OS细胞Akt/P53/P21通路的表达改变.结果 TRIM23蛋白在骨肉瘤细胞中的表达高于成骨细胞;沉默TRIM23基因可以抑制骨肉瘤细胞的增殖能力;沉默TRIM23基因下调P-Akt表达,但总Akt的表达无明显改变,上调P53与P21的表达.结论 TRIM23在骨肉瘤细胞中表达升高,TRIM23能通过调节Akt/P53/P21通路影响骨肉瘤细胞的增殖. 相似文献
4.
5.
Anja Thiede Paula Virtala Iina Ala-Kurikka Eino Partanen Minna Huotilainen Kaija Mikkola Paavo H.T. Leppänen Teija Kujala 《Clinical neurophysiology》2019,130(5):634-646
ObjectiveIdentifying early signs of developmental dyslexia, associated with deficient speech-sound processing, is paramount to establish early interventions. We aimed to find early speech-sound processing deficiencies in dyslexia, expecting diminished and atypically lateralized event-related potentials (ERP) and mismatch responses (MMR) in newborns at dyslexia risk.MethodsERPs were recorded to a pseudoword and its variants (vowel-duration, vowel-identity, and syllable-frequency changes) from 88 newborns at high or no familial risk. The response significance was tested, and group, laterality, and frontality effects were assessed with repeated-measures ANOVA.ResultsAn early positive and right-lateralized ERP component was elicited by standard pseudowords in both groups, the response amplitude not differing between groups. Early negative MMRs were absent in the at-risk group, and MMRs to duration changes diminished compared to controls. MMRs to vowel changes had significant laterality × group interactions resulting from right-lateralized MMRs in controls.ConclusionsThe MMRs of high-risk infants were absent or diminished, and morphologically atypical, suggesting atypical neural speech-sound discrimination.SignificanceThis atypical neural basis for speech discrimination may contribute to impaired language development, potentially leading to future reading problems. 相似文献
6.
7.
8.
9.
Xiaozhe Li Wenming Chen Yin Wu Jianyong Li Lijuan Chen Baijun Fang Ying Feng Junru Liu Meilan Chen Jingli Gu Beihui Huang Juan Li 《The oncologist》2019,24(11):e1132-e1140
10.
Frank H. C. Cheng Hon‐Yi Lin Tzy‐Wei Hwang Yin‐Chen Chen Rui‐Lan Huang Chia‐Bin Chang Weiqin Yang Ru‐Inn Lin Ching‐Wen Lin Gary C. W. Chen Shu‐Yuan Mai Jora M. J. Lin Yu‐Ming Chuang Jian‐Liang Chou Li‐Wei Kuo Chin Li Alfred S. L. Cheng Hung‐Cheng Lai Shu‐Fen Wu Je‐Chiang Tsai Michael W. Y. Chan 《Cancer science》2019,110(3):1085-1095