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目的: 系统评价代谢手术对肥胖型多囊卵巢综合征的影响。方法: 检索 PubMed、EMBASE、Cochrane Library、CNKI 和万方数据库。检索时间为 2000-01 ~ 2017-05。结局指标包括 PCOS、月经周期异常、多毛症、不
孕症。结果: 纳入的 19 篇报道中,共纳入接受代谢手术病人共 2716 例,其中女性病人 2274 例。经代谢手术后, PCOS 发生率术前12.27%术后降低为4.76%( 95%CI: 2.14 ~ 9.86,Z = 3.92,P<0.0001) 。月经周期异常发生率术前
34.43%术后降低为10.79%( 95%CI: 5.62~ 26.15,Z= 6.36,P<0.0001) 。多毛症发生率70.59%降低为21.01%( 95% CI: 3.57~ 31.06,Z= 4.27,P<0.0001) 。不孕症发生率7.69%术后降低为2.56% ( 95% CI: 1.77 ~ 5.81,Z = 3.85,P = 0.0001) 。结论: 代谢手术可显著改善肥胖型多囊卵巢综合征的临床症状。 相似文献
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Acute skin toxicity in adjuvant breast radiation can be reduced with modern radiotherapy (RT) techniques. However, having reviewed the literature, we found no dosimetric constraint for acute skin toxicity that would be applicable to modern RT planning. This study aimed to identify dosimetric factors that are associated with higher rates of acute skin toxicity. A retrospective review was carried out including women who received adjuvant forward-planned intensity-modulated radiotherapy (IMRT) after breast-conserving surgery. Acute skin toxicity grade was prospectively recorded. A total of 131 patients were analyzed. On multivariate analysis, the V105%?>?30?cc (p?=?0.013) and the use of conventional fractionation (CF) (p?=?0.001) were statistically significant for acute skin toxicity. On literature review, current quantitative dosimetric parameters that have shown statistical significance include a V107%?>?3?cc in hypofractionation (HF), V107%?>?9?cc in CF, treated volume 110%?>?5.13%, and V107%?>?28.6%. There is little evidence on the predictive value of clinically applicable dosimetric factors in acute skin toxicity. Given the recent improvements in RT planning, we would consider a V107% or a V110% too high a dosimetric value to be useful for the majority of patients. We have shown that a V105% of greater than 30?cc is significantly associated with acute skin toxicity, controlling for other variables. We suggest that this is currently the most useful modifiable parameter available to reduce skin toxicity and is applicable to modern RT planning. We also suggest that consideration be given to hypofractionated schedules to further reduce acute skin toxicity. 相似文献
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孤独症谱系障碍(ASD)是一种神经发育障碍性疾病,病因十分复杂。部分遗传代谢病(又称先天性代谢异常, IEM)患儿,同时伴有ASD或孤独样症状,对IEM的治疗能在一定程度上缓解ASD,因此IEM很可能是ASD的病因之一。本文就此讨论是否应该在ASD患儿中常规开展IEM筛查。 相似文献
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AbstractMetabolic syndrome (MetS) increases its prevalence during menopausal period and there is no appropriate marker for screening before the cardiovascular damage begun. This study aims to find the diagnostic accuracy and the appropriate cutoff level of serum adiponectin for the screening of MetS in peri- and postmenopausal women. Women aged at least 40?years old attending health checkup clinic were recruited. Anthropometric measurements, blood pressure, MENQOL, and blood chemistry (glucose, adiponectin, HDL-C, LDL-C, and TG) were recorded. MetS was defined by JIS 2009 criteria. 290 peri-and postmenopausal women mean age 54.25?±?8.6?years were recruited. 66% was postmenopause and 21.4% of them has MetS. The socioeconomic and lifestyle factors seem similar among women with and without MetS. In the participants with MetS, the prevalence of abdominal obesity was higher (96.8% vs 49.6%, p?<?.001, respectively) and more prevalence of android fat distribution pattern was observed (76.2% vs 36%, p?<?.001, respectively). Serum adiponectin was significantly lower in women with MetS (6.0?±?4.6 vs 9.2?±?5.2?μg/mL, p?<?.001 in MetS and non-MetS, respectively). Serum adiponectin is a good biomarker for MetS and we recommend the cutoff level of serum adiponectin lower than 7.15?μg/mL for screening of MetS (AUC (95% CI) of = 0.72 (0.64–0.79), p?<?.001). 相似文献
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目的:探讨恶性肿瘤、心血管病变和代谢疾病三者之间的关联。方法:搜索2018年9月1日至2018年10月31日期间在复旦大学附属中山医院心脏超声诊断科进行心脏超声心动图检查的患者,根据病史资料统计恶性肿瘤患者例数,并分析其合并心脏疾病和代谢疾病情况。结果:搜索行心脏超声心动图检查的患者共计26 698例,其中经病理检查或经影像学检查明确证实的恶性肿瘤患者1 992例,男性1 084例,女性908例,平均年龄(62.62±11.42)岁。左室射血分数平均值为(65.35±4.94)%。合并心脏疾病共220例,占11.04%。合并代谢疾病共1 052例,占52.81%。结论:恶性肿瘤患者在心脏超声心动图检查的患者中比例较高,合并心脏疾病、代谢疾病情况也不在少数;恶性肿瘤及相关治疗既能造成心脏疾病的发生又可导致代谢疾病的出现,故需对恶性肿瘤患者进行早期预防和干预治疗,以减少心脏疾病和代谢疾病的发生或加重。 相似文献
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Rosacea and the cardiometabolic syndrome are both associated with chronic inflammation and a pro‐inflammatory phenotype. Emerging clinical evidence supports the relationship between rosacea and cardiometabolic syndrome hypertension and obesity. This article reviews our current findings and understanding in the skin and cardiovascular relationship in rosacea. Rosacea appears to be associated with hypertension, dyslipidemia, and obesity. The role of smoking in rosacea is currently less clear. It remains uncertain whether treatment of these risk factors will aid improvement of rosacea. Greater understanding of rosacea and its association with the cardiovascular system and underlying risk factors could allow for a greater understanding of the body's inflammatory response as well as the formulation of new guidelines for attending clinicians. Dermatologists treating rosacea patients might need to consider enquiring and evaluate their patients' underlying cardiovascular risk factors. 相似文献