全文获取类型
收费全文 | 269804篇 |
免费 | 24297篇 |
国内免费 | 10471篇 |
专业分类
耳鼻咽喉 | 1659篇 |
儿科学 | 6751篇 |
妇产科学 | 4292篇 |
基础医学 | 54126篇 |
口腔科学 | 5315篇 |
临床医学 | 18326篇 |
内科学 | 46544篇 |
皮肤病学 | 4769篇 |
神经病学 | 19047篇 |
特种医学 | 5120篇 |
外国民族医学 | 76篇 |
外科学 | 18469篇 |
综合类 | 35137篇 |
一般理论 | 12篇 |
预防医学 | 17585篇 |
眼科学 | 3402篇 |
药学 | 31736篇 |
52篇 | |
中国医学 | 8294篇 |
肿瘤学 | 23860篇 |
出版年
2024年 | 156篇 |
2023年 | 3715篇 |
2022年 | 4870篇 |
2021年 | 9295篇 |
2020年 | 9344篇 |
2019年 | 9805篇 |
2018年 | 9200篇 |
2017年 | 9549篇 |
2016年 | 9332篇 |
2015年 | 11027篇 |
2014年 | 16046篇 |
2013年 | 18431篇 |
2012年 | 16388篇 |
2011年 | 19383篇 |
2010年 | 16362篇 |
2009年 | 15589篇 |
2008年 | 14959篇 |
2007年 | 14075篇 |
2006年 | 12821篇 |
2005年 | 11068篇 |
2004年 | 9822篇 |
2003年 | 8421篇 |
2002年 | 6663篇 |
2001年 | 5887篇 |
2000年 | 4851篇 |
1999年 | 4171篇 |
1998年 | 3292篇 |
1997年 | 3157篇 |
1996年 | 2671篇 |
1995年 | 2854篇 |
1994年 | 2563篇 |
1993年 | 2178篇 |
1992年 | 1797篇 |
1991年 | 1613篇 |
1990年 | 1316篇 |
1989年 | 1169篇 |
1988年 | 1050篇 |
1987年 | 808篇 |
1986年 | 772篇 |
1985年 | 1414篇 |
1984年 | 1299篇 |
1983年 | 908篇 |
1982年 | 1006篇 |
1981年 | 786篇 |
1980年 | 631篇 |
1979年 | 515篇 |
1978年 | 433篇 |
1977年 | 318篇 |
1976年 | 295篇 |
1975年 | 179篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
《Saudi Pharmaceutical Journal》2022,30(6):669-678
BackgroundIschemia reperfusion (I/R) play an imperative role in the expansion of cardiovascular disease. Sinomenine (SM) has been exhibited to possess antioxidant, anticancer, anti-inflammatory, antiviral and anticarcinogenic properties. The aim of the study was scrutinized the cardioprotective effect of SM against I/R injury in rat.MethodsRat were randomly divided into normal control (NC), I/R control and I/R + SM (5, 10 and 20 mg/kg), respectively. Ventricular arrhythmias, body weight and heart weight were estimated. Antioxidant, inflammatory cytokines, inflammatory mediators and plasmin system indicator were accessed.ResultsPre-treated SM group rats exhibited the reduction in the duration and incidence of ventricular fibrillation, ventricular ectopic beat (VEB) and ventricular tachycardia along with suppression of arrhythmia score during the ischemia (30 and 120 min). SM treated rats significantly (P < 0.001) altered the level of antioxidant parameters. SM treatment significantly (P < 0.001) repressed the level of creatine kinase MB (CK-MB), creatine kinase (CK) and troponin I (Tnl). SM treated rats significantly (P < 0.001) repressed the tissue factor (TF), thromboxane B2 (TXB2), plasminogen activator inhibitor 1 (PAI-1) and plasma fibrinogen (Fbg) and inflammatory cytokines and inflammatory mediators.ConclusionOur result clearly indicated that SM plays anti-arrhythmia effect in I/R injury in the rats via alteration of oxidative stress and inflammatory reaction. 相似文献
3.
4.
5.
6.
7.
Osama Y Safdar Rana M Baghdadi Sereen A Alahmadi Bana E Fakieh Amaal M Algaydi 《World Journal of Clinical Pediatrics》2022,11(1):14-26
Whether the underlying mutations are homozygous, heterozygous, or co-inherited with other hemoglobinopathies, sickle cell disease is known to afflict the kidneys, leading to the clinical entity known as sickle cell nephropathy (SCN). Although common, SCN remains diagnostically elusive. Conventional studies performed in the context of renal disorders often fail to detect early stage SCN. This makes the quest for early diagnosis and treatment more challenging, and it increases the burden of chronic kidney disease-related morbidity among patients. Novel diagnostic tools have been employed to overcome this limitation. In this study, we discuss various biomarkers of SCN, including those employed in clinical practice and others recently identified in experimental settings, such as markers of vascular injury, endothelial dysfunction, tubulo-glomerular damage, and oxidative stress. These include kidney injury molecule-1, monocyte chemoattractant protein-1, N-acetyl-B-D-glucosaminidase, ceruloplasmin, orosomucoid, nephrin, and cation channels, among others. Furthermore, we explore the potential of novel biomarkers for refining diagnostic and therapeutic approaches and describe some obstacles that still need to be overcome. We highlight the importance of a collaborative approach to standardize the use of promising new biomarkers. Finally, we outline the limitations of conventional markers of renal damage as extensions of the pathogenic process occurring at the level of the organ and its functional subunits, with a discussion of the expected pattern of clinical and biochemical progression among patients with SCN. 相似文献
8.
9.
Mixed lineage leukemia 1(MLL1)是组蛋白甲基转移酶SET家族的成员之一。MLL1与WDR5、RbBP5、Ash2L和DPY-30组成MLL1甲基转移酶复合物调控组蛋白H3的第4位赖氨酸的甲基化水平,对造血系统的发育和血细胞的更新至关重要。部分白血病患者体内存在因MLL1基因易位而产生的致癌蛋白——MLL1融合蛋白,MLL1融合蛋白在发挥其致癌作用时需要功能完整的MLL1酶复合物,故靶向MLL1-WDR5的蛋白-蛋白相互作用成为治疗MLL1融合型白血病的潜在策略。本文对MLL1-WDR5蛋白-蛋白相互作用的生物学机制、结构信息以及抑制剂进行了系统的总结,并结合已报道数据对该领域进行了展望,以期为后续研究提供参考。 相似文献
10.
Advances in vaccinia virus-based vaccine vectors,with applications in flavivirus vaccine development
《Vaccine》2022,40(49):7022-7031
Historically, virulent variola virus infection caused hundreds of millions of deaths. The smallpox pandemic in human beings has spread for centuries until the advent of the attenuated vaccinia virus (VV) vaccine, which played a crucial role in eradicating the deadly contagious disease. Decades of exploration and utilization have validated the attenuated VV as a promising vaccine vehicle against various lethal viruses. In this review, we focus on the advances in VV-based vaccine vector studies, including construction approaches of recombinant VV, the impact of VV-specific pre-existing immunity on subsequent VV-based vaccines, and antigen-specific immune responses. More specifically, the recombinant VV-based flaviviruses are intensively discussed. Based on the publication data, this review aims to provide valuable insights and guidance for future VV-based vaccine development. 相似文献