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1.
BackgroundAs an ongoing worldwide health issue, Coronavirus disease 2019 (COVID–19) has been causing serious complications, including pneumonia, acute respiratory distress syndrome (ARDS), and multi-organ failure. However, there is no decisive treatment approach available for this disorder, which is primarily attributed to the large amount of inflammatory cytokine production. We aimed to identify the effects of Nano-curcumin on the modulation of inflammatory cytokines in COVID-19 patients.MethodForty COVID-19 patients and 40 healthy controls were recruited and evaluated for inflammatory cytokine expression and secretion. Subsequently, COVID-19 patients were divided into two groups: 20 patients receiving Nano-curcumin and 20 patients as the placebo group. The mRNA expression and cytokine secretion levels of IL-1β, IL-6, TNF-α and IL‐18 were assessed by Real‐time PCR and ELISA, respectively.ResultOur primary results indicated that the mRNA expression and cytokine secretion of IL-1β, IL-6, TNF-α, and IL-18 were increased significantly in COVID-19 patients compared with healthy control group. After treatment with Nano-curcumin, a significant decrease in IL-6 expression and secretion in serum and in supernatant (P = 0.0003, 0.0038, and 0.0001, respectively) and IL-1β gene expression and secretion level in serum and supernatant (P = 0.0017, 0.0082, and 0.0041, respectively) was observed. However, IL-18 mRNA expression and TNF-α concentration were not influenced by Nano-curcumin.ConclusionNano-curcumin, as an anti-inflammatory herbal based agent, may be able to modulate the increased rate of inflammatory cytokines especially IL-1β and IL-6 mRNA expression and cytokine secretion in COVID-19 patients, which may cause an improvement in clinical manifestation and overall recovery. 相似文献
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This study intends to report the first emergence of lumpy skin disease (LSD) in Iraq, in addition to describing its related clinical signs. In August 2013, 21 cases of four outbreaks developed clinical signs suggestive of LSD in the Nineveh (Mosul) and Baghdad Governorates, which were considered as the first infected foci of LSD in Iraq. The disease was diagnosed tentatively, on the basis of clinical signs and epidemiological features, and it was confirmed as positive by the polymerase chain reaction and histopathological features. In September 2013, eight new outbreaks of LSD also appeared in Baghdad and Nineveh. In 2014, the disease spread rapidly to the governorates of Kirkuk, Salah Al‐Din, Al‐Anbar, Diyala, Wasit, Babil, Karbala, Najaf, Al‐Diwaniyah, Muthanna, Maysan, DhiQar and Basra. The total number of infected cows and calves reported was 7396 and 227, respectively. The apparent morbidity and mortality rates were 9.11% and 0.51%, respectively, while the apparent case‐fatality rate was 5.56%. Skin nodules, anorexia, reduce in milk production and decrease in bodyweight were the common clinical signs. Moreover, myiasis and mastitis were seen as complications in some infected animals. Attempts were made to stop the distribution of the disease including quarantine and treatment, control over animal movement and arthropod control. Ring vaccination was used in a 10 km radius zone around the outbreak with live sheep pox vaccine. The highly contagious transboundary nature of the LSD, its endemic distribution in the Iraqi neighbouring countries, and the current armed conflict in the area were the possible factors for the disease being introduced into the country. LSD had spread through the Middle East and Gulf peninsula and could be a cause of danger to the rest of Asia and Europe. International precaution, cooperation and exchange of information could guarantee the prevention and further spread of the disease to the rest of Asia and Europe. 相似文献
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目的:研究中国汉族人与日本人的头面部形态学差异。方法:按照《人体测量方法》的规定,于2009年8月测量了山西汉族成人体质数据,于2010年10月测量了四川汉族成人体质数据。将汉族和日本人体质资料进行了比较。结果:与日本人相比,汉族人身高较低,体质量略重,头的长、宽、高和头围较小,口较小,面部和鼻较高。结论:主成分分析结果表明,中国华北华中、西南汉族人体质较为接近,与东亚类型的日本人体质差距明显,主要表现在汉族人头的宽度、围度、高度、长度及身高小于日本人。 相似文献
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吴宁宁 《南通大学学报(哲学社会科学版)》2009,25(4):93-97
梁启超一直把改造国民性、提高国民素质作为强国新民的重要方式.其关于国民人格修养的思想集中体现了现代人格的特征.在人格论述上,梁启超把人格看作是合神格与兽格而成,人格的全部意义即在于调和神格与兽格使两者不偏轻偏重.因此他提出既要树立国民的尚武精神.又要打通道德与情感的通道,达致精神的增进.通过汇通中西,梁启超赋予人格修养以科学内涵,将其亲身领悟的西方现代文化的精髓与滋养其思想成长的传统文化的底蕴融入到他为强国新民而设计出的理想现代人格方法中.建立起了一套现代人格修养论. 相似文献
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Ethnopharmacological relevance
The people of Karamoja of northern Uganda chiefly rely on ethnoveterinary knowledge (EVK) to control common livestock health problems. In spite of cattle's central role in Karamojong culture and livelihoods, there has been no systematic recording of their ethnoveterinary plant-based cures to date.Aim of study
To document the remedies used to treat livestock diseases, their preparation and administration.Methods
Data were collected using semi-structured interviews, guided questionnaires, group discussions, direct observations and collection trips.Results
We present information on 209 plant species and 18 non-plant materials. Plant species are distributed over 116 genera and 54 families. The most common medicinal use was treatment against anaplasmosis. Balanites aegyptiacus, Carissa spinarum, Warburgia salutaris and Harrisonia abyssinica had the most uses of all species. All different plant parts were used; bark and underground parts were exploited more frequently than other plant parts. Most remedies listed used a single ingredient, typically soaked in water; only 12.8% remedies used multiple plants. The route of administration was primarily oral followed by topical applications. Almost all plants are collected from the wild; none of the few cultivated plants used had been planted for medicinal purposes.Conclusions
The pastoralists in the study site possess a wealth of EVK which they use to maintain animal health. Their rich knowledge and high diversity of plants were recorded here for the first time. 相似文献10.
The Conference was organized and supported by: Nei Dan School (European School of Internal Martial Arts), NIB (Laboratory of Molecular Biology and Stem Cell Bioengineering, National Institute of Biostructures and Biosystems, Institute of Cardiology, S.Orsola-Malpighi Hospital, Bologna), WACIMA (Worldwide Association Chinese Internal Martial Arts), Arti D'Oriente(Magazine of Eastern culture and traditions), Nuovo Orizzonte (Taiji Quan School in Florence), Samurai (Journal on Martial Arts), and Pinus (First National Institute for the Unification of Medical Strategies). Nei Dan School (www.taichineidan.com, neidan@libero.it) was in charge of the organization. Future meetings of the Centro studi 'Tao and Science' will take place in spring 2007 in Firenze and in October 2007 in Bologna. For information: E-mail: neidan@libero.it; web site: www.taichineidan.com, www.taoandscience.com. 相似文献