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1.
BackgroundIschemia reperfusion (I/R) play an imperative role in the expansion of cardiovascular disease. Sinomenine (SM) has been exhibited to possess antioxidant, anticancer, anti-inflammatory, antiviral and anticarcinogenic properties. The aim of the study was scrutinized the cardioprotective effect of SM against I/R injury in rat.MethodsRat were randomly divided into normal control (NC), I/R control and I/R + SM (5, 10 and 20 mg/kg), respectively. Ventricular arrhythmias, body weight and heart weight were estimated. Antioxidant, inflammatory cytokines, inflammatory mediators and plasmin system indicator were accessed.ResultsPre-treated SM group rats exhibited the reduction in the duration and incidence of ventricular fibrillation, ventricular ectopic beat (VEB) and ventricular tachycardia along with suppression of arrhythmia score during the ischemia (30 and 120 min). SM treated rats significantly (P < 0.001) altered the level of antioxidant parameters. SM treatment significantly (P < 0.001) repressed the level of creatine kinase MB (CK-MB), creatine kinase (CK) and troponin I (Tnl). SM treated rats significantly (P < 0.001) repressed the tissue factor (TF), thromboxane B2 (TXB2), plasminogen activator inhibitor 1 (PAI-1) and plasma fibrinogen (Fbg) and inflammatory cytokines and inflammatory mediators.ConclusionOur result clearly indicated that SM plays anti-arrhythmia effect in I/R injury in the rats via alteration of oxidative stress and inflammatory reaction.  相似文献   
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目的探讨糖尿病足溃疡(DFU)患者中性粒细胞淋巴细胞比值(NLR)与其病变严重程度的相关性及对预后的预测价值。方法回顾性分析2016年6月—2020年6月收治的DFU 176例的临床资料。收集入院时NLR、C反应蛋白(CRP)等指标,分析不同DFU病情、下肢缺血及感染程度NLR水平。根据随访6个月时转归分为预后良好组和预后不良组,应用多因素Logistic回归分析DFU患者预后不良的危险因素,并采用受试者工作特征(ROC)曲线评估NLR对DFU患者预后不良的预测价值。结果随病情严重程度、下肢缺血程度、感染程度加重NLR水平逐渐升高(P<0.01)。176例随访6个月后溃疡预后不良60例(34.09%)。NLR>6.58、CRP>58.35 mg/L是DFU患者预后不良的危险因素。NLR以7.17为临界值预测DFU患者预后不良的曲线下面积高于CRP(P<0.01)。结论DFU患者短期预后不良风险高,NLR能反映其病变程度,且早期预测预后不良的价值高于CRP。  相似文献   
4.
下肢动脉硬化闭塞症介入术后的主要难题是再狭窄。脂肪酸结合蛋白4(FABP4)主要由巨噬细胞分泌,促进巨噬细胞内脂质积聚,从而使巨噬细胞转化为泡沫细胞,造成动脉粥样硬化。在动脉粥样硬化闭塞介入术后,血管内皮细胞也能特异性分泌FABP4;FABP4作用于血管平滑肌细胞,使之增殖和迁移形成增生内膜,并促进炎症反应,造成介入术后再狭窄。提示FABP4可能是治疗动脉粥样硬化和介入术后再狭窄的一个重要靶点。本文简述FABP4的生物学特性与功能,并就其在动脉粥样硬化及介入术后再狭窄中的作用及机制进行综述。  相似文献   
5.
Numerous risk variables, including age, medical co-morbidities, and deranged inflammatory response, lead to higher mortality in a senior population with coronavirus disease 2019. C-reactive protein (CRP), an acute phase inflammatory protein secreted by the liver, was tested in the elderly, showing a diagnostic and prognostic role. However, recent research has shed light on new applications for CRP in geriatrics. It was used as a follow-up marker and as a therapeutic target. Early and accurate identification of patients' risks may mitigate the devastation of the invading virus in older cases and permit the implementation of a quick treatment plan for those most likely to deteriorate.  相似文献   
6.
Valproic acid (VPA) is an anti-seizure drug that causes idiosyncratic liver injury. 2-propyl-4-pentenoic acid (Δ4VPA), a metabolite of VPA, has been implicated in VPA-induced hepatotoxicity. This review summarizes the pathogenesis involved in VPA-induced liver injury. The VPA induce liver injury mainly by i) liberation of Δ4VPA metabolites; ii) decrease in glutathione stores and antioxidants, resulting in oxidative stress; iii) inhibition of fatty acid β-oxidation, inducing mitochondrial DNA depletion and hypermethylation; a decrease in proton leak; oxidative phosphorylation impairment and ATP synthesis decrease; iv) induction of fatty liver via inhibition of carnitine palmitoyltransferase I, enhancing nuclear receptor peroxisome proliferator-activated receptor-gamma and acyl-CoA thioesterase 1, and inducing long-chain fatty acid uptake and triglyceride synthesis. VPA administration aggravates liver injury in individuals with metabolic syndromes. Therapeutic drug monitoring, routine serum levels of transaminases, ammonia, and lipid parameters during VPA therapy may thus be beneficial in improving the safety profile or preventing the progression of DILI.  相似文献   
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We propose a Deep learning-based weak label learning method for analyzing whole slide images (WSIs) of Hematoxylin and Eosin (H&E) stained tumor tissue not requiring pixel-level or tile-level annotations using Self-supervised pre-training and heterogeneity-aware deep Multiple Instance LEarning (DeepSMILE). We apply DeepSMILE to the task of Homologous recombination deficiency (HRD) and microsatellite instability (MSI) prediction. We utilize contrastive self-supervised learning to pre-train a feature extractor on histopathology tiles of cancer tissue. Additionally, we use variability-aware deep multiple instance learning to learn the tile feature aggregation function while modeling tumor heterogeneity. For MSI prediction in a tumor-annotated and color normalized subset of TCGA-CRC (n=360 patients), contrastive self-supervised learning improves the tile supervision baseline from 0.77 to 0.87 AUROC, on par with our proposed DeepSMILE method. On TCGA-BC (n=1041 patients) without any manual annotations, DeepSMILE improves HRD classification performance from 0.77 to 0.81 AUROC compared to tile supervision with either a self-supervised or ImageNet pre-trained feature extractor. Our proposed methods reach the baseline performance using only 40% of the labeled data on both datasets. These improvements suggest we can use standard self-supervised learning techniques combined with multiple instance learning in the histopathology domain to improve genomic label classification performance with fewer labeled data.  相似文献   
8.
《Vaccine》2022,40(27):3721-3726
We initiated a randomized, placebo-controlled, phase 1/2 trial to evaluate the safety and immunogenicity of the S-268019-b recombinant protein vaccine, scheduled as 2 intramuscular injections given 21 days apart, in 60 randomized healthy Japanese adults. We evaluated 2 regimens of the S-910823 antigen (5 μg [n = 24] and 10 μg [n = 24]) with an oil-in-water emulsion formulation and compared against placebo (n = 12). Reactogenicity was mild in most participants. No serious adverse events were noted. For both regimens, vaccination resulted in robust IgG and neutralizing antibody production at days 36 and 50 and predominant T-helper 1-mediated immune reaction, as evident through antigen-specific polyfunctional CD4+ T-cell responses with IFN-γ, IL-2, and IL-4 production on spike protein peptides stimulation. Based on the interim analysis, the S-268019-b vaccine is safe, produces neutralizing antibodies titer comparable with that in convalescent serum from COVID-19-recovered patients. However, further evaluation of the vaccine in a large clinical trial is warranted.  相似文献   
9.
目的探讨乙肝相关性肝癌临床病理学特征与溶血磷脂酸(LPA)和高敏C反应蛋白(hs-CRP)表达的相关性。方法选取2019年1月至2020年1月间河南省驻马店市中心医院收治的198例乙肝相关性肝癌患者作为乙肝组,198例酒精相关性肝癌患者作为酒精组。两组患者都进行血清hs-CRP和LPA表达检测,调查患者的病理学特征并进行相关性分析。结果乙肝组患者血清hs-CRP和LPA含量均高于酒精组,差异均有统计学意义(均P <0.05)。两组患者血清ALP、AFP、ALT、AST和GGT含量比较,差异均无统计学意义(P> 0.05)。乙肝组不同临床分期和组织学分化患者的血清hs-CRP和LPA含量比较,差异均有统计学意义(均P <0.05)。乙肝组患者的临床分期和组织学分化与血清hs-CRP和LPA表达均存在相关性,差异均有统计学意义(均P <0.05)。患者的临床分期和组织学分化均为影响hs-CRP和LPA表达的重要因素,差异均有统计学意义(均P <0.05)。结论相对于酒精相关性肝癌,乙肝相关性肝癌的血清hs-CRP和LPA呈现高表达,与患者的临床病理学特征存在相关性。  相似文献   
10.
目的探究p27蛋白、细胞周期素E(cyclin-E)在子宫内膜异位症(EMT)患者中的表达及与患者临床病理特征、妊娠关系。 方法选取2016年1月至2021年1月江西省九江市妇幼保健院81例EMT合并不孕患者为EMT组,另选择同期60例非EMT患者为对照组。采用免疫组化法检测子宫内膜组织p27蛋白、cyclin-E表达情况,以半定量法评价镜下染色强度、阳性细胞百分比,统计p27蛋白、cyclin-E阳性表达情况。 结果EMT组异位内膜、在位内膜组织p27蛋白阳性率55.56%、58.02%,均显著低于对照组正常内膜组织的81.67%(P<0.05),EMT组异位内膜、在位内膜组织cyclin-E阳性率69.14%、51.85%均显著高于对照组的25.00%(P<0.05)。81例EMT患者中,浸润型异位内膜组织p27蛋白阳性率36.36%较卵巢型的62.71%下降、cyclin-E阳性率90.91%较卵巢型的62.07%升高(P<0.05),Ⅲ~Ⅳ期异位内膜组织p27蛋白阳性率39.02%较Ⅰ~Ⅱ期的72.50%下降、cyclin-E阳性率82.93%较Ⅰ~Ⅱ期的55.00%升高(P<0.05)。Spearman相关分析显示,p27蛋白表达与cyclin-E表达、美国生育协会分类系统(rAFS)评分呈负相关(P<0.05),与子宫内膜容受性Salle评分呈正相关(P<0.05);cyclin-E表达与Salle评分呈负相关(P<0.05),与rAFS评分呈正相关(P<0.05)。81例患者术后24个月累计妊娠共38例(46.91%),其中p27蛋白表达阳性者妊娠率57.78%,较阴性者的33.33%高(P<0.05),而cyclin-E表达阳性者妊娠率37.50%,较阴性者的68.00%低(P<0.05)。调整年龄、体重指数、月经周期、术前痛经数字评分(NRS)评分、Salle评分、美国生育协会分类系统(rAFS)评分等因素后发现,cyclin-E表达阳性是术后24个月妊娠结局的影响因素(P<0.05)。 结论p27蛋白在EMT患者中呈低表达、cyclin-E呈高表达,二者均与患者临床分型、分期及病情严重程度表现出一定相关性,其中cyclin-E高表达可能与患者妊娠结局有关。  相似文献   
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