Updates in diagnosis and management of pancreatic cysts

Incidental pancreatic cysts are commonly encountered with some cysts having malignant potential. The most common pancreatic cystic neoplasms include serous cystadenoma, mucinous cystic neoplasm and intraductal papillary mucinous neoplasm. Risk stratifying pancreatic cysts is important in deciding whether patients may benefit from endoscopic ultrasound (EUS) or surgical resection. Surgery should be reserved for patients with malignant cysts or cysts at high risk for developing malignancy as suggested by various risk features including solid mass, nodule and dilated main pancreatic duct. EUS may supplement magnetic resonance imaging findings for cysts that remain indeterminate or have concerning features on imaging. Various cyst fluid markers including carcinoembryonic antigen, glucose, amylase, cytology, and DNA markers help distinguish mucinous from nonmucinous cysts. This review will guide the practicing gastroenterologist in how to evaluate incidental pancreatic cysts and when to consider referral for EUS or surgery. For presumed low risk cysts, surveillance strategies will be discussed. Managing pancreatic cysts requires an individualized approach that is directed by the various guidelines.     

Papillary Cystadenoma of Minor Salivary Glands: Report of 11 Cases and Review of the English Literature

Papillary cystadenoma is a rare, benign salivary gland tumor which is well-circumscribed, containing cystic cavities with intraluminal papillary projections. Only 19 cases arising within minor salivary glands (MnSG) from the oral cavity sites have been reported in the English literature (PubMed 1958–2014). We report 11 new cases of MnSG papillary cystadenomas in conjunction with a review of the literature. Demographic information, clinical and histologic features, treatment and prognosis are compiled and discussed for all 30 cases reported in the English literature.     

Cystic neoplasms of the pancreas

As the use of cross-sectional imaging has become more frequent, there has been an increase in the diagnosis of cystic neoplasms and small non-functioning neuroendocrine neoplasms within the pancreas. Investigation and follow-up of cystic lesions of the pancreas requires a multimodal approach, of which endoscopic ultrasound with biopsy is becoming an increasingly important component. The main premalignant cystic neoplasms of the pancreas are mucinous-type tumours, intraductal papillary mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN). Main-duct IPMN should be resected due to the high incidence of underlying malignancy; however, a selective approach to intervention for side-branch IPMN should be taken (dependent on the presence of symptoms, tumour markers and tumour characteristics). Pancreatic neuroendocrine neoplasms (PanNENs) can also present as cystic lesions in approximately 18% of cases. Biochemically confirmed functional PanNEN and non-secreting PanNENs larger than 2 cm in size should be evaluated for surgery.     

Solid serous cystadenoma of the pancreas: MR imaging with pathologic correlation

We report a case of solid type serous cystadenoma of the pancreas. Computed tomographic and magnetic resonance (MR) images showed a hypervascular solid tumor that was difficult to differentiate from endocrine tumor of the pancreas. However, the tumor showed marked hyperintensity similar to that of hepatic cyst on MR cholangiopancreatography, indicating not a solid but rather a cystic nature. MR cholangiopancreatography (heavily T2-weighted image) is quite useful for clearly differentiating solid from cystic tumors.     

肝胆管囊腺瘤的临床表现和影像学诊断

目的 探讨肝胆管囊腺瘤的临床特征和CT表现,以提高该病的术前诊断水平.方法 回顾性分析3例经手术切除并经病理证实的肝胆管囊腺瘤的临床表现和CT特点,并结合文献复习.结果 3例肝胆管囊腺瘤患者,男1例,女2例.临床表现为肝区疼痛不适,1例出现发热、黄疸；血清肿瘤标记物检查1例CA199轻度升高.1例病灶位于肝左叶,2例位于肝右叶,均表现为囊实性肿块,实性成分动脉期轻中度强化,静脉期持续强化.结论 肝胆管囊腺瘤好发于中年女性,影像学表现有一定的特征性.     

Laparoscopic management of appendicular mucinous cystadenoma,case report

IntroductionAppendectomy is the most common emergency surgical procedure performed worldwide. Mucinous cystadenoma is a rare benign tumor of the appendix. There is no agreement on the best surgical approach for its management. Recently, laparoscopic approach is being increasingly tried. Careful excision of the tumor is mandatory to avoid content spillage into peritoneum resulting in pseudomyxoma peritonei.Case presentationA middle-age male patient presented to the emergency department complaining of chronic abdominal pain, bleeding per rectum and recurrent attacks of vomiting. Preoperative imaging confirmed presence of cystic lesion in the right lower quadrant. He underwent a diagnostic laparoscopy with resection of appendicular mucocele. The histopathological examination confirmed the diagnosis of appendicular mucinous cystadenoma. He was followed up in the clinic for two years.ConclusionAppendicular mucinous cystadenoma should be considered in differential diagnosis of cystic mass detected in the right lower quadrant of the abdomen on US or CT. Laparoscopic excision of the tumor is safe and feasible with extra care taken to avoid pseudomyxoma peritonei.’