首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   263篇
  免费   11篇
  国内免费   2篇
耳鼻咽喉   3篇
基础医学   9篇
口腔科学   3篇
临床医学   48篇
内科学   27篇
皮肤病学   19篇
神经病学   3篇
特种医学   6篇
外科学   14篇
综合类   33篇
预防医学   55篇
眼科学   10篇
药学   28篇
中国医学   15篇
肿瘤学   3篇
  2023年   4篇
  2022年   2篇
  2021年   7篇
  2020年   6篇
  2019年   5篇
  2018年   4篇
  2017年   6篇
  2016年   6篇
  2015年   11篇
  2014年   15篇
  2013年   20篇
  2012年   9篇
  2011年   19篇
  2010年   17篇
  2009年   9篇
  2008年   9篇
  2007年   13篇
  2006年   9篇
  2005年   10篇
  2004年   8篇
  2003年   5篇
  2002年   5篇
  2001年   5篇
  2000年   5篇
  1999年   2篇
  1998年   5篇
  1997年   4篇
  1996年   4篇
  1995年   4篇
  1994年   5篇
  1993年   3篇
  1992年   3篇
  1991年   2篇
  1990年   8篇
  1989年   2篇
  1988年   1篇
  1987年   6篇
  1986年   2篇
  1985年   9篇
  1984年   3篇
  1983年   2篇
  1982年   1篇
  1981年   1篇
排序方式: 共有276条查询结果,搜索用时 15 毫秒
1.
Dialkylcarbamoylchloride (DACC)‐coated cotton acetate dressing works directly through hydrophobic interaction to reduce the number of bacteria without the risk of resistance. It is easy to use and therefore expected to improve patient's compliance. This study aimed to assess the clinical efficacy of DACC‐coated cotton acetate dressing compared to a combination of normal saline dressing and 2% mupirocin ointment. A single‐blind controlled trial was conducted and included 14 infected epidermolysis bullosa (EB) wounds which were divided into two groups. Group I received DACC‐coated cotton acetate dressing, and Group II received the combination of normal saline dressing and 2% mupirocin ointment. Study results showed that the average time required for complete wound closure was 8.6 and 11.1 days in Groups I and II, respectively (p = .014), which was statistically significant. Both groups showed complete bacterial elimination on Day 3 based on negative Gram stain results and on Day 6 based on clearance of clinical manifestations (p = 1.000). This is a novel study in EB‐infected wounds, which shows that DACC‐coated cotton acetate dressing promotes faster wound closure and is as effective as the combination of normal saline dressing and 2% mupirocin ointment in eliminating bacterial infection.  相似文献   
2.
Fatty acyl‐CoA reductases (FARs), the enzymes that catalyse reduction of a fatty acyl‐CoA to the corresponding alcohol in insect pheromone biosynthesis, are postulated to play an important role in determining the proportion of each component in the pheromone blend. For the first time, we have isolated and characterized from the Egyptian cotton leaf worm Spodoptera littoralis (Lepidoptera: Noctuidae) a FAR cDNA (Slit‐FAR1), which appeared to be expressed only in the pheromone gland and was undetectable in other female tissues, such as fat body, ovaries, wings, legs or thorax. The encoded protein has been successfully expressed in a recombinant system, and the recombinant enzyme is able to produce the intermediate fatty acid alcohols of the pheromone biosynthesis of S. littoralis from the corresponding acyl‐CoA precursors. The kinetic variables Km and Vmax, which have been calculated for each acyl‐CoA pheromone precursor, suggest that in S. littoralis pheromone biosynthesis other biosynthetic enzymes (e.g. desaturases, acetyl transferase) should also contribute to the final ratio of components of the pheromone blend. In a phylogenetic analysis, Slit‐FAR1 appeared grouped in a cluster of other FARs involved in the pheromone biosynthesis of other insects, with little or non‐specificity for the natural pheromone precursors.  相似文献   
3.
摘要 目的 比较棉签拭子与接触碟(Rodac)对不同硬质表面微生物、织物、不同环境(实验室、医院)现场微生物以及人工染菌物体表面的采样效果,为现场微生物采集方法选择提供科学参考。方法 采用棉拭子采样倾注培养法和Rodac接触碟压印法分别对环境中微生物进行采集。结果 棉拭子对织物表面的微生物捕获量高于Rodac接触碟;Rodac接触碟对较洁净的硬质表面微生物捕获量高于棉拭子。Rodac接触碟对人工污染的金黄色葡萄球菌和大肠杆菌捕获量均高于棉拭子。结论 两种采样方法对不同表面污染的微生物捕获量不同,对不同微生物种类捕获量不同。  相似文献   
4.
霍山石斛的抗炎作用   总被引:1,自引:0,他引:1  
目的:观察霍山石斛的抗炎作用。方法:60只昆明种小鼠,随机分为正常组、模型组、石斛高、中、低剂量组(4,2,1 g·kg~(-1)),醋酸地塞米松组(醋酸地塞米松,0. 01 g·kg~(-1));连续灌胃给药14 d;末次给药1 h后,于小鼠右耳的耳中部两侧滴二甲苯20μL建立耳肿胀模型。1 h后断头处死所有小鼠,计算各组小鼠耳肿胀率。健康SD大鼠36只,分别为正常组、模型组、霍山石斛高、中、低(2. 8,1. 4,0. 7 g·kg~(-1))剂量组、醋酸地塞米松组。连续灌胃给药7 d。末次灌胃给药1 h后,于各组大鼠的右后肢足趾皮下注射10%新鲜鸡蛋清建立足肿胀模型。分别于0,0. 5,1,2,3,4,5 h时,测量各大鼠的右后足周长,计算大鼠的足肿胀度。取SD大鼠60只,向双侧腹股沟皮下植入无菌干燥棉球,分组同上。第2天灌胃给药,连续14 d。末次给药后,取出棉球,计算肉芽肿抑制率;检测各组大鼠血清中肿瘤坏死因子-α(TNF-α),白细胞介素-1β(IL-1β),白细胞介素-2(IL-2),白细胞介素-6(IL-6),γ-干扰素(IFN-γ)含量。结果:与正常组比较,模型组耳肿胀率、足肿胀度显著升高(P 0. 01);与模型组比较,霍山石斛高、中、低剂量组均可明显降低小鼠耳肿胀率(P 0. 01);霍山石斛高、中剂量组足肿胀度明显降低(P0. 05,P 0. 01);给药各组棉球肉芽干重显著下降(P 0. 01),胸腺、脾脏指数没有显著性变化;与正常组比较,模型组大鼠血清中炎症因子含量显著升高(P 0. 01);与模型组比较,霍山石斛高、中、低剂量组和醋酸地塞米松组炎症因子含量显著降低(P 0. 05,P 0. 01)。结论:霍山石斛能够有效抑制急、慢性炎症反应。  相似文献   
5.
This study aimed to investigate the wear failure changes of spindle hook teeth and the reasons for such failure during field work. Spindle samples were obtained from a fixed position of the spindle bar under different field picking area conditions and combined with the spatial distribution characteristics of cotton bolls in Xinjiang. After cutting a spindle sample, a scanning electron microscope and an energy spectrum analyzer were used to characterize the micromorphology and element composition of the hook tooth surface and cross section under different working area conditions. The wear parameters of the hook teeth were then extracted. The results showed that the thickness of the coating on the surface of the hook tooth used in this study was between 66.1 µm and 74.4 µm. The major chemical element was chromium, with a small amount of nickel. During the field picking process, failure of the coating on the surface of the hook teeth initially appeared on the tooth tip and tooth edge, and then spread to the entire hook tooth surface. The wear failure of the hook teeth resulted from abrasive wear, oxidative wear, and fatigue peeling. As the picking area increased, the wear area of the hook teeth increased exponentially, while the wear width increased linearly. When the field picking area reached 533.33 ha, the maximum change rate of the wear area was 2.33 × 103 µm2/ha, and the wear width was 1.84 µm/ha. During field work, the thickness of the coating decreased from the cutting surface to the tooth edge, and the wear rate gradually increased. The wear rate at Position 1 was the slowest, at 0.01 µm/ha, and the wear rate at Position 5 was the fastest, at 0.25 µm/ha.  相似文献   
6.
7.
Cotton fabrics are highly popular because of their excellent properties such as regeneration, bio-degradation, softness, affinity to skin and hygroscopic properties. When in contact with the human body, cotton fabrics offer an ideal environment for microbial growth due to their ability to retain oxygen, moisture and warmth, as well as nutrients from spillages and body sweat. Therefore, an anti-microbial coating formulation (Microfresh and Microban together with zinc oxide as catalyst) was developed for cotton fabrics to improve treatment effectiveness. In addition, plasma technology was employed in the study which roughened the surface of the materials, improving the loading of zinc oxides on the surface. In this study, the low stress mechanical properties of plasma pre-treated and/or anti-microbial-treated cotton fabric were studied. The overall results show that the specimens had improved bending properties when zinc oxides were added in the anti-microbial coating recipe. Also, without plasma pre-treatment, anti-microbial-treatment of cotton fabric had a positive effect only on tensile resilience, shear stress at 0.5° and compressional energy, while plasma-treated specimens had better overall tensile properties even after anti-microbial treatment.  相似文献   
8.
目的:评价碘酊棉球填塞法急诊治疗牙龈出血的疗效。方法 :应用饱和2.5%碘酊溶液的棉球,对108例牙龈出血的急诊病例,进行填塞和压迫止血,观察15~30min,评价止血效果。结果:15min控制出血72例,占66.67%;30min控制出血36例,占33.33%。有效率达100%。结论:碘酊棉球填塞法急诊治疗牙龈出血方法简便、疗效可靠、复发率低,是一种有效的急诊止血方法。  相似文献   
9.
目的观察纳吸绵(NasoPore)和膨胀海绵(Merocel)在功能性鼻内窥镜(FESS)术后填塞的疗效对比。方法将92例功能性鼻窦内窥镜术后患者分为NasoPore组和Merocel组。术后分别置入鼻腔纳吸绵和膨胀海绵行填塞止血,观察两组患者术后疼痛率、出血率以及术腔恢复情况比较。结果 (1)NasoPore组疼痛率和出血率分别为80.43%和26.09%;Merocel组则为95.65%和66.30%;(2)在中鼻通粘连与筛窦内囊泡的方面,NasoPore组(23.91%)低于Merocel组(48.91%)。结论在FESS术中应用纳吸绵填塞能更有效的缓解患者术后疼痛、减少术区出血,因其可降解、无需抽取、减轻患者痛苦及减轻术区粘膜水肿,值得临床推广。  相似文献   
10.
目的 探究了新型脑棉片保存与清点袋在神经外科手术的效果运用。方法 回顾和分析了我院2013年-2015年的神经外科手术60例,按随机数字表法分为实验组(30例),对照组(30例)。实验组选用新型脑棉片保存与清点袋;对照组选用传统折叠式脑棉片保存包装。观察比较两组患者术中台面整理时间及脑棉片清点时间、手术台面污染情况及因清点不清暂停手术次数、估算术中出血量所用时间、脑棉片回收利用情况、护理人员工作满意度调查结果。结果 实验组在术中台面整理时间及脑棉片清点时间、手术台面污染情况及因清点不清暂停手术次数明显少于对照组。两组术中出血量平均估算值差别不大,但估算花费时间实验组少于对照组。在脑棉片回收利用情况中,脑棉片平均散落数、散落脑棉片平均变形数,实验组明显少于对照组,可消毒回收平均脑棉片数实验组大于对照组。实验组护理人员工作满意度明显优于对照组。结论 运用新型脑棉片保存与清点袋于神经外科手术中,可减少术中台面整理时间及脑棉片清点时间,改善手术台面污染情况,降低因清点不清暂停手术次数,便于估算出血量,在一定程度上提升了护理人员工作满意度,值得临床推广运用。  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号