全文获取类型
收费全文 | 30243篇 |
免费 | 2589篇 |
国内免费 | 574篇 |
专业分类
耳鼻咽喉 | 150篇 |
儿科学 | 884篇 |
妇产科学 | 321篇 |
基础医学 | 1934篇 |
口腔科学 | 253篇 |
临床医学 | 6054篇 |
内科学 | 6213篇 |
皮肤病学 | 164篇 |
神经病学 | 2859篇 |
特种医学 | 1292篇 |
外国民族医学 | 3篇 |
外科学 | 3682篇 |
综合类 | 3479篇 |
预防医学 | 1325篇 |
眼科学 | 1284篇 |
药学 | 1926篇 |
18篇 | |
中国医学 | 654篇 |
肿瘤学 | 911篇 |
出版年
2023年 | 605篇 |
2022年 | 629篇 |
2021年 | 1131篇 |
2020年 | 1277篇 |
2019年 | 1138篇 |
2018年 | 1051篇 |
2017年 | 1154篇 |
2016年 | 1111篇 |
2015年 | 1089篇 |
2014年 | 2121篇 |
2013年 | 2203篇 |
2012年 | 1886篇 |
2011年 | 1935篇 |
2010年 | 1607篇 |
2009年 | 1495篇 |
2008年 | 1345篇 |
2007年 | 1355篇 |
2006年 | 1262篇 |
2005年 | 1075篇 |
2004年 | 943篇 |
2003年 | 799篇 |
2002年 | 695篇 |
2001年 | 617篇 |
2000年 | 449篇 |
1999年 | 415篇 |
1998年 | 359篇 |
1997年 | 340篇 |
1996年 | 267篇 |
1995年 | 295篇 |
1994年 | 288篇 |
1993年 | 254篇 |
1992年 | 236篇 |
1991年 | 190篇 |
1990年 | 168篇 |
1989年 | 150篇 |
1988年 | 153篇 |
1987年 | 118篇 |
1986年 | 139篇 |
1985年 | 217篇 |
1984年 | 165篇 |
1983年 | 110篇 |
1982年 | 124篇 |
1981年 | 118篇 |
1980年 | 83篇 |
1979年 | 57篇 |
1978年 | 53篇 |
1977年 | 43篇 |
1976年 | 27篇 |
1975年 | 18篇 |
1974年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
目的结合文献回顾观察Aicardi-Goutières综合征(AGS)影像学表现。方法回顾性分析3例经基因检测证实的AGS患儿,患儿月龄分别为3、5、8个月,均接受颅脑MR检查,其中1例(病例3)接受颅脑CT检查,结合文献分析其颅脑MRI及CT表现。结果颅脑MRI显示,病例1双侧侧脑室、双侧额颞部脑外间隙增宽;病例2未见明显异常;病例3脑萎缩,双侧侧脑室前角旁异常呈T1WI等信号、T2WI及T2-液体衰减翻转恢复(T2-FLAIR)序列呈稍高信号。颅脑CT显示病例3脑萎缩,双侧基底核区、双侧侧脑室前角旁钙化,双侧侧脑室前角旁低密度灶。结论颅内钙化、脑萎缩和脑白质营养不良为AGS常见影像学表现。 相似文献
2.
3.
BackgroundCentrally located pancreatic lesions are often treated with extended pancreaticoduodenectomy or distal pancreatectomy resulting in loss of healthy parenchyma and a high risk of diabetes and exocrine insufficiency. Robotic central pancreatectomy (RCP) is a parenchyma sparring alternative that has been shown safe and feasible [[1], [2]].MethodsIn this article, we describe our operative technique and the perioperative outcomes of a series of RCP for low-grade or benign pancreatic tumors.ResultsSix patients (5 female and 1 man) with a median age of 51.5 (44–68) years underwent a RCP for 2 serous cystadenomas, 2 mucinous cystic tumors, 1 neuroendocrine tumor, and 1 autoimmune pancreatitis. There were no conversions, intraoperative complications, or perioperative transfusions. Median operative time and was 240 (230–291) minutes and median blood loss was 100 (100–400) ml. The median hospital stay was 8 (5–27) days. There were no mortalities, reoperations, or readmissions. One patient developed a grade B pancreatic fistula which was successfully managed conservatively. All resections had free margins and the median tumor size was 2.5 (1.5–3.5) cm. After a mean follow-up of 46 months, no patients presented new-onset diabetes or exocrine insufficiency.ConclusionsRCP represents the least invasive option for both the patient and the pancreatic parenchyma. With a standardized technique, RCP results in low postoperative morbidity and excellent long-term pancreatic function. Although our results are excellent, POPF still represents the main complication of central pancreatectomy with an incidence ranging from 0 to 80% depending on multiple factors such as the surgeon, technique, and pancreatic texture. 相似文献
4.
《Journal of emergency nursing》2022,48(4):484-491
BackgroundCalcium chloride is commonly used in emergency departments in the treatment of a variety of emergencies. Historically, administration via central venous catheters has been preferred owing to its high osmolarity and vesicant properties. Although preferred, central access may not always be available in time-sensitive, emergent situations leading to many instances of peripheral administration. The objective of this analysis was to evaluate the charted safety of peripheral venous administration of 10% calcium chloride.MethodsA single-center retrospective chart review was performed in patients who received 10% calcium chloride in the adult emergency department evaluating for the incidence of infusion-related adverse events. Patients were excluded if they were less than 18 years of age or had a lack of catheter documentation during 10% calcium chloride administration or if the 10% calcium chloride was documented as given through a central venous catheter.ResultsA total of 72 administrations were evaluated. Patients were predominantly male (67%), with a median age of 55 years and body mass index of 29.2. The primary outcome demonstrated that 4 infusion-related adverse events occurred (6%) with grade 1 (n = 1) and grade 0 (n = 3) documented incidence of infusion-related adverse events. None of the documented incidence of infusion-related adverse events resulted in permanent tissue injury, and all patients had conservative management.DiscussionThis study demonstrated that administration of 10% calcium chloride via peripheral venous catheters may be feasible and seemed to carry a low incidence of documented complications. Further prospective studies are needed to confirm study observations. 相似文献
5.
6.
7.
慢性疼痛是一种复杂的身心疾病,包括躯体痛觉异常、认知障碍、负性情绪等多个方面的改变,同时伴随着神经系统的功能以及结构的改变。本文将对慢性疼痛与下行疼痛调节通路、疼痛情感-认知调控网络以及中脑边缘奖赏网络的相关性,以及针刺镇痛的中枢机制相关研究文献进行综述,旨在探讨下行疼痛调节通路、疼痛情感-认知调控网络以及中脑边缘奖赏网络在慢痛发生机制中的作用,为临床治疗慢性疼痛类疾病提供更优势的治疗方案。 相似文献
8.
9.
10.
眼静脉空气栓塞(OVAE)是玻璃体切割手术中一种罕见的致命并发症。因手术部位靠近心脏且位于心脏上方,OVAE可能是所有手术中引起静脉空气栓塞(VAE)最严重的。随着玻璃体切割手术的发展,免缝合状态的灌注套管可出现向外滑动,使得灌注气体进入脉络膜上腔,导致涡静脉撕裂。玻璃体腔气体灌注时,外伤及脉络膜黑色素瘤手术导致的脉络膜血管伤口暴露于气体中,这使得加压气体可能通过撕裂的涡静脉或异常的脉络膜静脉开口进入循环系统导致OVAE。目前OVAE的定义、发病机制、临床表现及防治措施在不断完善,但多数玻璃体视网膜外科医生和麻醉医师仍不了解该医源性并发症。提高对OVAE的认识将有助于早期发现该并发症,进而做出及时处理,同时制定有效的预防策略。通过临床和实验室研究相结合,可不断优化OVAE防治原则。充分认识OVAE的发病机理和临床特点,关注 OVAE继发性病变的特征以及重视多学科间的合作有助于OVAE应急处理和预防措施的建立和完善。 相似文献