全文获取类型
收费全文 | 43544篇 |
免费 | 5931篇 |
国内免费 | 1100篇 |
专业分类
耳鼻咽喉 | 147篇 |
儿科学 | 535篇 |
妇产科学 | 467篇 |
基础医学 | 4708篇 |
口腔科学 | 685篇 |
临床医学 | 3820篇 |
内科学 | 1956篇 |
皮肤病学 | 434篇 |
神经病学 | 982篇 |
特种医学 | 2001篇 |
外国民族医学 | 76篇 |
外科学 | 5415篇 |
综合类 | 5764篇 |
现状与发展 | 7篇 |
一般理论 | 1篇 |
预防医学 | 1857篇 |
眼科学 | 140篇 |
药学 | 2492篇 |
35篇 | |
中国医学 | 856篇 |
肿瘤学 | 18197篇 |
出版年
2024年 | 167篇 |
2023年 | 728篇 |
2022年 | 1524篇 |
2021年 | 2220篇 |
2020年 | 2031篇 |
2019年 | 1772篇 |
2018年 | 1659篇 |
2017年 | 1766篇 |
2016年 | 1934篇 |
2015年 | 2268篇 |
2014年 | 2948篇 |
2013年 | 3116篇 |
2012年 | 2451篇 |
2011年 | 2610篇 |
2010年 | 1984篇 |
2009年 | 1846篇 |
2008年 | 1880篇 |
2007年 | 1963篇 |
2006年 | 1951篇 |
2005年 | 1744篇 |
2004年 | 1450篇 |
2003年 | 1409篇 |
2002年 | 1145篇 |
2001年 | 1044篇 |
2000年 | 816篇 |
1999年 | 732篇 |
1998年 | 602篇 |
1997年 | 576篇 |
1996年 | 485篇 |
1995年 | 433篇 |
1994年 | 324篇 |
1993年 | 286篇 |
1992年 | 250篇 |
1991年 | 248篇 |
1990年 | 184篇 |
1989年 | 180篇 |
1988年 | 162篇 |
1987年 | 146篇 |
1986年 | 136篇 |
1985年 | 203篇 |
1984年 | 189篇 |
1983年 | 127篇 |
1982年 | 154篇 |
1981年 | 149篇 |
1980年 | 126篇 |
1979年 | 95篇 |
1978年 | 79篇 |
1977年 | 70篇 |
1976年 | 78篇 |
1973年 | 42篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Norwani Basir Pemasari Upali Telisinghe Vui Heng Chong 《The Indian journal of surgery》2015,77(6):545-546
Paraneoplastic pemphigus is a relatively rare but significant acquired autoimmune mucocutaneous disorder that is characterised by diffuse erythema, painful blistering and sores of the skin and mucus membranes. The underlying pathogenesis is believed to be triggered by altered immune system in response to underlying neoplasm. The manifestations can predate, occur at the same time or after the diagnosis of cancer. Associations with gastric cancer have only been reported twice. A 78-year-old lady presented with a month’s history of extensive skin lesions that started off as bullous lesions and biopsy revealed bullous pemphigus. Endoscopy for anemia revealed gastric cancer. This case reinforced the need to consider underlying malignancy in elderly patient with new onset dermatological presentation. 相似文献
2.
Puja Vijay Parikh 《International journal of environmental health research》2016,26(4):458-466
Environmental chemical exposure could be an important etiologic factor for geographic differences in breast cancer incidence. In this study, we examined emissions of polycyclic aromatic hydrocarbons (PAHs) and PM2.5 in relation to breast cancer incidence in metro Atlanta and rural Georgia by analyzing data from the Surveillance, Epidemiology, and End Results Program and the Environmental Protection Agency. The results showed that metro Atlanta had a significantly higher age-adjusted annual incidence rate of female breast cancer than rural Georgia (132.6 vs. 113.7 per 100,000) for 1992–2011. Emissions of both PAHs [adjusted β = 0.568 (95 % CI: 0.209, 0.927); p = 0.004] and PM2.5 [adjusted β = 2.964 (95 % CI: 0.468, 5.459); p = 0.023] were significantly associated with breast cancer incidence in metro Atlanta area. This study suggests that ambient air pollution, especially PAHs and PM2.5, could have a significant impact on the increased incidence of female breast cancer in urban areas. 相似文献
3.
4.
Background and aimPatient decision aids for oncological treatment options, provide information on the effect on recurrence rates and/or survival benefit, and on side-effects and/or burden of different treatment options. However, often uncertainty exists around the probability estimates for recurrence/survival and side-effects which is too relevant to be ignored. Evidence is lacking on the best way to communicate these uncertainties. The aim of this study is to develop a method to incorporate uncertainties in a patient decision aid for breast cancer patients to support their decision on radiotherapy.MethodsFirstly, qualitative interviews were held with patients and health care professionals. Secondly, in the development phase, thinking aloud sessions were organized with four patients and 12 health care professionals, individual and group-wise.ResultsConsensus was reached on a pictograph illustrating the whole range of uncertainty for local recurrence risks, in combination with textual explanation that a more exact personalized risk would be given by their own physician. The pictograph consisted of 100 female icons in a 10 x 10 array. Icons with a stepwise gradient color indicated the uncertainty margin. The prevalence and severity of possible side-effects were explained using verbal labels.ConclusionsWe developed a novel way of visualizing uncertainties in recurrence rates in a patient decision aid. The effect of this way of communicating risk uncertainty is currently being tested in the BRASA study (NCT03375801). 相似文献
5.
6.
目的 探讨Lugol液染色对食管早期癌和癌前病变的诊断价值。方法 对45例食管黏膜可疑病变经内镜以2%Lugol液喷洒染色,观察黏膜染色情况,并取活检送病理组织学检查。结果 45例食管病变染色后,39例呈浅染色或不染色,其中食管癌8例(食管早期癌5例,进展期癌3例),Barrett食管5例,轻至中度不典型增生1l例。本组Lugol液染色对食管早期癌和癌前病变的检出率达46.7%。结论 内镜下应用Lugol液染色结合活检有助于食管早期癌和癌前病变的诊断,且操作简便,具有重要的临床价值。 相似文献
7.
Chronicsofttissuelesionisaspeciallymedicalterm,andanimportantpathologicalchangesofdiseases,suchaschronicoveruseinjuriesandconversionofacuteinjuriesinlowbackorfrominter-vertebraldiscprotrusion,anddislocationofintervertebraljointsaswell,whichmainlycauseseverepaininlowback犤1犦.Manypresentmethods(oralmedicine,massage,anestheticblock,physicalthera-piesetc.)havebeenusedforrelievingthepain,whichdemandsagreatfiscalsupportannually.Unfortunately,thereportsonthemechanismsandeffectofthem… 相似文献
8.
B. A. Stoll 《Annals of oncology》1997,8(3):223-225
Background: The study reviews the anticancer properties of naturalisoflavones which occur in especially high concentration in soybeans. Itconsiders the suitability of soybean products for clinical trials aiming toreduce the progression of breast cancer.Methods: Evidence is reviewed that plant isoflavones such asgenistein show cytostatic activity against human mammary cancer cell linesin vitro and can also suppress carcinogen-induced mammary cancer inyoung and mature rats.Results: Plant isoflavones are converted in the bowel to compoundswith potential antioestrogenic and antioxidative properties. These compoundsshow cytostatic activity for both oestrogen receptor-positive and negativehuman mammary cancer cell lines, and also inhibit growth and progress of therat mammary cancer model. The high content of soybean products in the diet ofAsian women has been postulated as one reason for their relatively low breastcancer incidence.Conclusion: Preclinical studies suggest that soybean products begiven priority for clinical trials in breast cancer protection. A pilot studycould test soy protein supplements as long-term adjuvant dietary treatmentafter primary surgery for early breast cancer, looking for a decrease in therisk of recurrence or of second primary tumours. 相似文献
9.
John R. Jarrett M.D. 《Aesthetic plastic surgery》1990,14(1):87-92
Immediate reconstruction of more than 1000 breasts was performed on high-risk patients on whom a prophylactic mastectomy was done. The mastectomy removes as much breast tissue as possible while leaving sufficient skin, and possibly the nipple-areola complex, to enable immediate reconstruction. The creation of symmetrical, well-balanced muscle pockets for the implant is the most important factor in producing satisfactory results in these cases. 相似文献
10.
47例原发性乳腺癌多药耐药MDR1基因表达及其临床意义 总被引:3,自引:0,他引:3
[目的]探讨原发性乳腺癌多药耐药MDR1基因的表达及其临床意义.[方法]采用荧光定量RT-PCR法检测47例乳腺癌组织及15例正常对照(包括5例乳腺纤维腺瘤、10例癌旁组织)MDR1基因的表达.[结果]乳腺癌MDR1基因表达阳性率为46.8%,与病人年龄、肿瘤大小、淋巴结转移与否、ER、PR状况、绝经与否无关.对照组中无MDR1基因表达.[结论]乳腺癌MDR1基因的表达可作为乳腺癌化疗耐药的评价指标,能否作为判断预后的独立指标尚需进一步研究. 相似文献