Adeno-associated virus mediated apoA-I and apoA-IMilano expression in skeletal muscular cells

INTRODUCTION Human apolipoproteinA-I (apoA-I) is a singlepolypeptide chain,composed of 243 amino acids ,and it is the major protein constituent of high densitylipoprotein(HDL)inblood.HDLplays a critical roleinthe process of reverse cholesterol transport(RCT),inwhich HDL mediates excess cholesterol efflux frompe-ripheral tissues and transported to the liver forcatabolism[1].The antiatherogenic properties of apoA-Iandits inverse correlation with the incidence of cardio-vascular diseas…