Influence of task complexity during coordinated hand and foot movements in MS patients with and without fatigue

Kinematic and functional magnetic resonance imaging were combined to investigate how movement complexity (in-phase vs. anti-phase) and rate (maximum rate vs. 1 Hz) influence the brain sensorimotor network of relapsing- remitting fatigued (F) and notfatigued (NF) MS patients during the performance of coordinated hand and foot movements. Kinematic measures did not differ between F and NF patients. Task and disease showed an interaction in the right precuneus and posterior lobe of the cerebellum during in-phase/anti-phase conditions and in the right precuneus and posterior and anterior lobes of the cerebellum during maximum vs. 1 Hz rate. Task, disease and fatigue showed an interaction in the right precentral gyrus, the left postcentral gyrus, the left SII, the right precuneus, the right basal ganglia, the left lingual gyrus, and the posterior lobe of the cerebellum, bilaterally, during in-phase/ anti-phase conditions and the left postcentral gyrus, the left SII, the right anterior lobe of the cerebellum, and the posterior lobe of the cerebellum, bilaterally during maximum vs. 1 Hz rate. Investigations of motor task performance in MS patients require careful control of several variables, including task complexity, movement rate, and the presence of “subtle” clinical disturbances, such as fatigue, which might be underestimated at a standard neurological assessment.     

西洋参SOD脂质体的制备工艺优选和性质评价

目的:优选西洋参SOD脂质体的制备工艺并考察其性质.方法:采用逆相蒸发法制备西洋参SOD脂质体,以包封率为指标,通过正交试验考察卵磷脂-胆固醇、磷酸盐缓冲液体积及西洋参SOD加入量对制备工艺的影响,考察西洋参SOD脂质体的粒径分布、体外释放和稳定性.结果:最佳制备工艺为卵磷脂-胆固醇(4:1),磷酸盐缓冲液体积12 mL,西洋参SOD加入量10 mg,制备的西洋参SOD脂质体形态均匀,平均粒径480 nm,平均包封率71.35％.结论:制备的脂质体包封率高、稳定性良好,具有一定的缓释效果.