卒中后认知障碍与软脑膜侧支循环的代偿程度及静脉溶栓治疗的相关性分析

目的：比较急性缺血性卒中患者卒中后认知障碍的发生与软脑膜侧支循环的代偿程度及是否接受静脉溶栓治疗的相关性。方法：前瞻性收集2019年1月至2021年3月在石河子市人民医院住院的急性前循环脑梗死患者161例，获取患者入院时人口学资料，包括是否溶栓、性别、合并症等；通过蒙特利尔认知评估量表（Montreal cognitive assessment,MoCA）评分、简易精神状态检查量表（mini mental state examination,MMSE）评分评估患者认知功能；入院时美国国立卫生院卒中量表（National Institute of Health Stroke Scale,NIHSS）评分获取患者神经功能缺损症状；通过Blessed行为量表（Blessed behavior scale,BBS）评分评估患者的日常生活能力；通过区域软脑膜评分（regional leptomeningeal collateral score,rLMC）获取患者软脑膜侧支循环；根据卒中后6个月是否合并认知障碍分为认知障碍组和非认知障碍组，采用logistic多因素回归方法进行统计比较，分析2组患...     

参麦注射液联合阿替普酶静脉溶栓治疗45例急性缺血性脑卒中患者的疗效观察

目的:探究参麦注射液联合阿替普酶静脉溶栓治疗急性缺血性脑卒中(AIS)患者疗效及安全性。方法:选取某院90例AIS患者,按照治疗方案不同分为对照组和观察组,各45例。对照组采用阿替普酶静脉溶栓治疗,观察组在对照组基础上加用参麦注射液治疗,观察分析两组临床疗效及不良反应发生情况。结果:观察组治疗总有效率高于对照组(P<0.05),观察组总不良反应发生率低于对照组(P<0.05)。结论:参麦注射液联合阿替普酶静脉溶栓治疗AIS可提升疗效,提高临床安全性。     

醒脑静与阿替普酶溶栓治疗急性脑梗死的价值

目的探讨醒脑静结合阿替普酶溶栓治疗急性脑梗死的临床价值。方法纳入我院收治的80例急性脑梗死患者,入选开始时间自2017年10月-2019年10月,将其按照住院序号奇偶数不同分成两组,各40例。其中奇数设为对照组,给予阿替普酶治疗;偶数组设为研究组,给予醒脑静联合治疗,对比两组的疗效及治疗前后的凝血、纤溶指标变化情况。结果研究组疗效较对照组更有优越性(P <0.05)。研究组治疗后的凝血、纤溶指标较对照组改善更明显(P <0.05)。结论醒脑静结合阿替普酶溶栓治疗急性脑梗死可有效提高疗效,改善凝血、纤溶指标,值得在临床中使用。     

低剂量阿替普酶溶栓治疗急性缺血性脑卒中研究进展

阿替普酶静脉溶栓是目前医治急性缺血性脑卒中的最佳措施.虽然各大指南推荐的阿替普酶应用剂量为0.9 mg/kg(最大剂量90 mg),但近年来越来越多的观察性研究认为,低剂量阿替普酶(0.6 mg/kg)溶栓治疗可取得与标准剂量同样的疗效,并可减少症状性颅内出血的发生,不过目前循证医学证据不足.本文围绕低剂量阿替普酶治疗急性缺血性脑卒中现有研究进行综合阐述,希望为临床医生提供参考.     

重组人尿激酶原与阿替普酶溶栓治疗急性ST段抬高型心肌梗死的作用评价

目的探究重组人尿激酶原与阿替普酶溶栓治疗急性ST段抬高型心肌梗死(STEMI)的疗效及临床安全性。方法制定入组标准,选取STEMI患者100例,随机均分为尿激酶原组(50例)和阿替普酶组(50例)。分析两组冠状动脉造影结果,比较患者接受静脉溶栓后病变血管再通情况,观察并记录各项临床事件。结果与阿替普酶组比较,尿激酶原组患者在接受静脉溶栓后24 h内冠状动脉通畅率更高;尿激酶原组和阿替普酶组患者溶栓后24 h内冠状动脉造影发现,溶栓后存在补救性PCI指征(TIMI 0～1级)患者数量的差异有显著性(10.0%比38.0%,加权前P＝0.021,加权后P＝0.025);TIMI 0级、TIMI 1级、TIMI 4级的患者数量两组差异有显著性,TIMI 3级的患者数量两组间差异无显著性。两组在临床终点事件、住院期间不良事件发生率以及随访过程中不良事件发生率方面的差异无统计学意义。结论与阿替普酶相比,重组人尿激酶原在急性心肌梗死的治疗方面具有更好的疗效和安全性,值得临床推广应用。     

Successful treatment of ischemic stroke associated with brachiocephalic artery stenosis using alteplase

Introduction: Brachiocephalic artery stenosis rarely causes right hemispheric infarction with associated left hemiparesis. To date, there have been no reported cases of stroke associated with brachiocephalic artery stenosis that were successfully treated with recombinant tissue-type plasminogen activator (rt-PA), alteplase.Case Report: An 80-year-old woman presented with left hemiparesis. Brain computed tomography showed no hemorrhage, and computed tomography angiography demonstrated brachiocephalic artery stenosis. Alteplase was administered based on a diagnosis of ischemic stroke. Brain magnetic resonance imaging showed multiple acute infarctions. Thereafter, the blood pressure of the right arm was found to be lower than that of the left arm. The patient’s neurological deficits gradually improved; she was eventually able to walk again and was thus discharged home.Conclusion: While the combination of left hemiparesis and a decrease in blood pressure in the right arm are well known in patients with stroke associated with Stanford type A aortic dissections, it may also occur in patients with stroke due to brachiocephalic artery stenosis. Unlike stroke associated with Stanford type A aortic dissections, stroke due to brachiocephalic artery stenosis may be treated with alteplase.     

Evaluation of Alteplase 1 mg for the Restoration of Occluded Central Venous Access Devices in a Tertiary Care Hospital

Background

Alteplase is a recombinant tissue plasminogen activator that is approved for the treatment of occluded central venous access devices (CVADs) and is commercially available as a 2?mg/2?mL dose. Due to the increasing price of 2?mg/2?mL alteplase vials, our institution switched to using a 1?mg/1?mL dose for certain CVADs. The purpose of this study was to evaluate the use, effectiveness, and cost of a maximum of 2 doses of 1?mg/1?mL alteplase for the restoration of an occluded catheter.

急性缺血性卒中静脉溶栓治疗后大脑中动脉再通患者的临床预后研究

目的：探讨急性缺血性卒中接受重组组织型纤溶酶原激活剂（ Recombinant Tissue Plasminogen Activa-tor,rt-PA）静脉溶栓治疗后大脑中动脉再通患者的临床预后情况。方法回顾性分析2013年9月至2014年9月,于天津市环湖医院神经内科接受静脉溶栓治疗的急性缺血性卒中患者资料552例。入选患者按照0．9 mg／kg剂量标准,给予rt-PA静脉溶栓治疗。所有患者于溶栓前及溶栓后24 h进行头部MRA检查,采用TICI血管再通分级标准判断大脑中动脉的再通情况。其中根据溶栓后24 h MRA检查结果分为血管再通组（188例）,血管未通组（364例）。溶栓前及溶栓后24 h的神经功能缺损评分及疗效判定,采用美国国立卫生研究院卒中量表（ National Institute of Health Stroke Scale,NIHSS）。神经功能的预后评价,采用改良Rankin评分（ modified Rankin Scale,mRS）。对2组患者溶栓后颅内出血（ intracranial hemorrhage,ICH）、症状性颅内出血（ symptomatic intracranial hemorrhage,SICH）的发生率、死亡率、神经功能缺损恢复及预后情况进行统计对比分析。结果血管再通组患者的恢复良好率和预后良好率均高于血管未通组,差异有统计学意义（ P ＜0．05）。血管再通组患者未出现症状性颅内出血,有6例患者出现了非症状性颅内出血。血管再通组及血管未通组的颅内出血发生率、其他部位出血率和住院期间死亡率差异均无统计学意义（P＞0．05）。结论研究结果表明,急性缺血性卒中患者在接受静脉溶栓治疗后,大脑中动脉再通的患者较未通患者神经功能缺损症状改善明显。静脉溶栓后,血管再通的患者临床预后获益更大。     

Isolated Anisocoria as a Presenting Stroke Code Symptom is Unlikely to Result in Alteplase Administration

Background

Acute stroke codes may be activated for anisocoria, but how often these codes lead to a final stroke diagnosis or alteplase treatment is unknown. The purpose of this study was to assess the frequency of anisocoria in stroke codes that ultimately resulted in alteplase administration.