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1.
目的:探讨中西医结合治疗急性痛风性关节炎的疗效。方法:63例符合急性痛风性关节炎患者随机分为治疗组与对照组,治疗组以四黄水密局部冷敷并口服扶他林治疗,对照组以秋水仙碱口服,进行为期一周的治疗观察。结果:治疗组总有效率90.3%,对照组总有效率87.5%,差异有显著意义(P〈0.05),且治疗组不良反应的发生率明显低于对照组。结论:四黄水密冷敷联合扶他林治疗急性痛风性关节炎疗效确切,不良反应少。  相似文献
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目的观察三妙散加味配合芙菊膏外敷治疗急性痛风性关节炎的临床疗效。方法将140例急性痛风性关节炎随机分为2组,治疗组采用三妙散加味(苍术、黄柏、川牛膝、延胡索、当归尾、蒲公英、地龙、山慈菇、滑石)煎汤内服,并配合芙菊膏(鲜野菊花、鲜芙蓉叶、鲜芦荟捣泥加大黄粉)外敷治疗。对照组予西药秋水仙碱治疗。1个疗程均为2周。治疗前后分别检查关节肿痛分数、关节疼痛的缓解时间、血尿酸、血脂等指标。结果总有效率治疗组77.14%,对照组为57.14%,两组比较,差异有显著性意义(P〈0.05);治疗组愈显率61.43%,对照组愈显率24.29%,两组比较,差异有非常显著性意义(P〈0.01)。治疗组治疗后血尿酸及血脂各项指标改善明显,与治疗前比较,差异有显著性意义(P〈0.05);2组治疗后血尿酸和血脂各项指标比较,差异有显著性意义(P〈0.05);2组治疗后关节疼痛缓解时间比较,差异有显著性意义(P〈0.05)。结论三妙散加味配合芙菊膏治疗急性痛风性关节炎疗效确切,使用安全。  相似文献
3.
抗痛风胶囊治疗大鼠急性痛风性关节炎及下调TNF-α水平   总被引:1,自引:0,他引:1  
目的观测抗痛风胶囊(AGC)治疗急性痛风性关节炎(AGA)时肿瘤坏死因子(TNF-α)水平的变化,探讨AGC的作用机制。方法大鼠随机分为5组,关节腔内注射尿酸钠制备AGA模型,容积法测定关节容积,ELISA法定量测定血清及关节液中TNF-α含量。结果与模型组比较,高、低剂量的AGC(0.3g.kg-1.d-1和1.2g.kg-1.d-1)和阳性药(秋水仙碱0.8mg/kg)均明显降低AGA大鼠踝关节容积,减少尿酸钠所致关节肿胀程度,明显改善大鼠步态。模型组外周血血清和关节液中TNF-α含量均明显高于空白组,AGC和秋水仙碱均降低AGA大鼠外周血血清和关节液中TNF-α的含量,但AGC组TNF-α水平下降更明显。结论 AGC对大鼠AGA具有明显治疗作用,其机制与降低血循环和关节液的TNF-α水平,减轻消除炎症损伤有关。  相似文献
4.
目的探讨白艾痛风灵免煎颗粒剂治疗急性痛风性关节炎的作用机制。方法造兔急性痛风性关节炎模型,观察白艾痛风灵免煎颗粒剂对兔痛风性关节炎模型关节液中TNF-α、IL-1β含量的影响,并与模型组、秋水仙碱组和正常组进行对比。结果模型组关节液中TNF-α、IL-1β含量明显高于正常组(P〈0.01),白艾痛风灵组和秋水仙碱组TNF-α、IL-1β的含量明显低于模型组(P〈0.01);白艾痛风灵组和秋水仙碱组TNF-α、IL-1β的含量与正常组比较,差异无统计学意义。结论白艾痛风灵免煎颗粒剂对急性痛风性关节炎具有一定的治疗作用。  相似文献
5.
目的:观察金黄散外敷结合微波照射对急性痛风性关节炎的临床疗效。方法:将75例急性痛风性关节炎发作期患者随机分为治疗组40例与对照组35例。对照组采用单纯西药内服治疗;治疗组在对照组基础上加用中药四妙丸合五苓散(简称四五合剂)内服、金黄散醋调外敷、局部微波照射等治疗。结果:治疗组总有效率为92.5%,对照组为:71.4%,两组疗效比较有显著性差异(P<0.05)。治疗组治疗后血沉、血尿酸、胆固醇、甘油三酯均有明显下降,与治疗前比较,差异均有显著意义(P<0.05)。结论:金黄散外敷结合微波照射对急性痛风性关节炎发作期疗效好,具有显著协同作用,安全好。  相似文献
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Objective: To study the therapeutic effect of treatment of acute gouty arthritis (AGA) respectively by electroacupuncture (EA) with different frequency and oral intake of Western medicine. Methods: Seventy-two patients of AGA were randomly assigned into three groups, 24 in each group. Group A was treated with EA 100 Hz; Group B with EA 2 Hz; and Group C with Western medicine. The analgesic effect, initiating time and sustaining time of analgesia were observed and the level of serum uric acid was measured before and after treatment. Results:The initiating time of analgesia was shorter while the sustaining time of analgesia was longer in Group A and B than those in Group C (all P<0. 01). The efficacy of analgesia was higher in Group B than that in Group A , and a better effect was shown in Group B in reducing serum uric acid level than that in Group A (P<0.01), which was near that in Group C (P>0.05). Conclusion: EA is an effective treatment for AGA, and low frequency (2 Hz) EA showed a better efficacy.  相似文献
8.
目的研究痛风速效宁对高尿酸血症并急性痛风性关节炎模型大鼠不同时相的影响,探讨其治疗急性痛风性关节炎的作用机制。方法将雄性SD大鼠96只随机分为3组,模型对照组(A)、秋水仙碱组(B)、痛风速效宁组(C),用氧嗪酸钾和尿酸钠分别行腹腔和踝关节腔内注射制造高尿酸血症并急性痛风性关节炎模型,各组于造模前3 h和造模后3 h分别予灌胃生理盐水、秋水仙碱和痛风速效宁干预,并于造模后6、12、24、36 h 4个时相各取8只大鼠,采血、取关节液和滑膜,比较3组在血尿酸、关节液白细胞和尿酸盐晶体方面的变化。结果①痛风速效宁可降低实验大鼠的血尿酸水平,与模型对照组比较P<0.01;②痛风速效宁可加速致炎大鼠的关节液中尿酸盐晶体的清除,与模型对照组比较P<0.01;③痛风速效宁可抑制致炎大鼠的关节液中WBC渗出、抑制和改善致炎大鼠的关节滑膜炎症反应程度,与秋水仙碱组比较P>0.05,与模型对照组比较P<0.05。结论痛风速效宁对高尿酸血症并急性痛风性关节炎模型大鼠具有治疗作用。  相似文献
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Objective: To observe the clinical effect of Rebixiao granule (RBXG) in treating repeatedly attacking acute gouty arthritis and through experimental study on blood uric acid to explore RBXGs therapeutic mechanism.Methods: Ninety repeatedly attacking acute gouty arthritis patients were divided into the treated group (n = 60) and control group (n = 30). The treated group was treated with RBXG, and the control group was treated with Futalin tablets (diclofenac sodium). The baseline treatment including good rest, low purine diet, sufficient water drinking and urine alkalization, etc. was then given to both groups. Hypoxanthine 600 mg/kg and niacin 100 mg/kg was applied to hyperuricemic mice by gastrogavage to establish the animal models.Results: The clinical effective rate of the treated group was 95.0% and that of the control 90.0%. Good therapeutic effects were won, insignificant difference (P>0.05)was shown between the two groups. However, the cure rate of the treated group was 26.7% while that of the control group was 10.0%, with significant difference (P<0.01) shown between them. The treated group had its blood uric acid lowered, which was significantly different (P<0.05) from that of the control group. The animal experiment indicated that all the three groups treated with different dosages of RBXG, as well as the Ash bark and Smilax glabra rhizome groups had their blood uric acid content reduced in the hyperuricemic mice.Conclusion: RBXG has a quicker initiation and better treatment effects than sole anti-inflammatory and analgesic agents on the treatment of repeatedly attacking acute gouty arthritis, showing no obvious toxic or adverse reactions and therefore good for long-term administration and likely to be a safe TCM preparation to control the symptoms and reduce the onsets of repeatedly attacking of acute gouty arthritis. The animal experiment shows that both the compound preparation and part of the single ingredients in the recipe have the function of reducing blood uric acid. However, the compound recipe has better therapeutic effects, proving to be superior to single drugs. Supported by Project of Science and Technology Commission Foundation of Jiangsu Province in 1998;  相似文献
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