肝素钠微生物限度检查方法适用性研究

目的 建立肝素钠的微生物限度检查方法。方法 采用2015年版中国药典(四部)通则下方法,对肝素钠进行方法适用性试验,确定适宜的微生物限度检查方法。结果 计数方法采用薄膜过滤法,各试验菌比值均在0.5~2范围内,控制菌采用常规法,各阳性试验菌均检出,阴性对照均无菌生长。结论 所验证的肝素钠微生物限度检查方法是可行的。     

Understanding online health information: Evaluation,tools, and strategies

ObjectiveConsidering the status of the Internet as a prominent source of health information, assessing online health material has become a central issue in patient education. We describe the strategies available to evaluate the characteristics of online health information, including readability, emotional content, understandability, usability.MethodsPopular tools used in assessment of readability, emotional content and comprehensibility of online health information were reviewed. Tools designed to evaluate both printed and online material were considered.ResultsReadability tools are widely used in online health material evaluation and are highly covariant. Assessment of emotional content of online health-related communications via sentiment analysis tools is becoming more popular. Understandability and usability tools have been developed specifically for health-related material, but each tool has important limitations and has been tested on a limited number of health issues.ConclusionDespite the availability of numerous assessment tools, their overall reliability differs between readability (high) and understandability (low). Approaches combining multiple assessment tools and involving both quantitative and qualitative observations would optimize assessment strategies.Practice implicationsEffective assessment of online health information should rely on mixed strategies combining quantitative and qualitative evaluations. Assessment tools should be selected according to their functional properties and compatibility with target material.     

出境人员检测氯胺酮的适宜性探讨

〔目的〕探讨氯胺酮作为出国人员毒品检测项目的适宜性。〔方法〕分析氯胺酮在人体内的代谢过程,比较氯胺酮及其代谢产物的检测方法。〔结果〕氯胺酮代谢快,代谢半衰期短,检测方法多,但是快速检测方法存在取材时间限制,检出限低等问题。〔结论〕对出国人员来说,目前没有适宜的、操作性强的氯胺酮检测方法。     

基于遥感和地理信息系统技术宁夏枸杞适宜性的分布范围

宁夏枸杞为中药材枸杞子在《中国药典》中收录的唯一药用基原植物,其主要分布于我国北部的宁夏、甘肃、青海、内蒙、新疆等地,为常用大宗药材之一。由于需求量大,枸杞子早已供不应求,现大多数枸杞子为引种栽培品,但因各地生态环境、地理条件有诸多差异导致枸杞品质参差不齐,市场流通商品品质混乱。因此本文从文献、第四次中药资源普查与中药资源动态监测工作的基础上,确定出宁夏枸杞分布区域的海拔、年均温、年降水、土壤类型、坡向、日照时数6个因子的范围,并在遥感和地理信息系统(GIS)技术的协助下,结合野外实地调查验证,最终确定宁夏枸杞适宜分布区域。     

家庭亲密度和适应性对晚期肝硬化患者生活质量的影响

目的探讨家庭亲密度和适应性对晚期肝硬化患者生活质量的影响作用。方法采用家庭亲密度和适应性量表中文版（FACESⅡ-CV）对晚期肝硬化患者进行测评,选取家庭亲密度评分≥65分、适应性≥53分的80例患者为观察组,家庭亲密度评分〈65分、适应性〈53分的76例患者为对照组,应用生活质量综合评定量表（GQOH-74）、情感量表比较两组患者的生活质量及心理素质。结果观察组患者生活质量、心理素质评分高于对照组,差异均有统计学意义（P〈0．01）。结论在治疗及护理晚期肝硬化患者躯体疾病的同时,更应注意部分晚期肝硬化患者对家庭亲密度的感受,并有针对性地对晚期肝硬化患者及家属开展社会心理干预,提高适应性,从而促进康复,达到提高患者生活质量的目的。     

山东省社会医疗保障水平的测量及适宜度

评估社会医疗保障适度水平对社会医疗保险制度的运行与调整具有非常重要的意义。对山东省社会医疗保障水平进行测算分析,重点考察了社会医疗保障水平与经济发展的协调度,并就制度发展和政策优化提出了建议。     

EPAGE no es una estrategia eficaz para la gestión de colonoscopias durante la pandemia por COVID-19

IntroductionThe pandemic caused by the SARS-CoV-2 virus has had a serious impact on the functioning of gastrointestinal endoscopy Units. The Asociación Española de Gastroenterología (AEG) and the Sociedad Española de Endoscopia Digestiva (SEED) have proposed the EPAGE guidelines for managing postponed colonoscopies.ObjectiveTo evaluate the EPAGE guidelines as a management tool compared to the immunologic faecal occult blood test (iFOBT) and compared to risk score (RS) that combines age, sex and the iFOBT for the detection of colorectal cancer (CRC) and significant bowel disease (SBD).MethodsA prospective, single-centre study enrolling 743 symptomatic patients referred for a diagnostic colonoscopy. Each order was classified according to the EPAGE guidelines as appropriate, indeterminate or inappropriate. Patients underwent an iFOBT and had their RS calculated.ResultsThe iFOBT (p<0.001), but not the EPAGE guidelines (p = 0.742), was an independent predictive factor of risk of CRC. The ROC AUCs for the EPAGE guidelines, the iFOBT and the RS were 0.61 (95% CI 0.49-0.75), 0.95 (0.93-0.97) and 0.90 (0.87-0.93) for CRC, and 0.55 (0.49-0.61), 0.75 (0.69-0.813) and 0.78 (0.73-0.83) for SBD, respectively. The numbers of colonoscopies needed to detect a case of CRC and a case of SBD were 38 and seven for the EPAGE guidelines, seven and two for the iFOBT, and 19 and four for a RS ≥5 points, respectively.ConclusionThe EPAGE guidelines, unlike the iFOBT, is not suitable for screening candidate patients for a diagnostic colonoscopy to detect CRC. The iFOBT, in combination with age and sex, is the most suitable strategy for managing demand for endoscopy in a restricted-access situation.     

南药化橘红全球产地适宜性分析

目的:通过化橘红全球产地适宜性分析,为南药化橘红的合理种植和科学产地规划提供重要依据。方法:以化橘红主产区的95个样点为分析基点,结合气温、相对湿度、日照强度、年降水量、土壤类型等关键生态因子值,采用药用植物全球产地适宜性区划信息系统(GMPGIS)对化橘红在全球的生态适宜区域进行分析。结果:化橘红的最大生态相似度区域主要分布于中国、巴西、美国和越南等国家的热带和亚热带区域,总面积约210万km2,其中中国占总面积的60%以上;中国适宜区主要分布于广西、湖南、江西、云南和广东等省。结论:本研究结果为合理规划化橘红种植生产布局,发展引种栽培工作提供了科学参考依据。     

富马酸卢帕他定片微生物限度检查的适用性试验

目的：建立富马酸卢帕他定片微生物限度检查方法。方法：按照2015年版《中国药典》四部通则1105和1106微生物限度检查法中的微生物计数法和控制菌检查法进行验证。结果：所有试验菌（金黄色葡萄球菌、铜绿假单胞菌、枯草芽胞杆菌、白色念珠菌、黑曲霉）的回收率均在0.5~2范围内,采用常规法即可检出大肠埃希菌。结论：该方法有效可行,可用于富马酸卢帕他定片的微生物限度检查。