基于图书馆知识资本循环系统支持的隐性知识转移机制研究

概述知识资本理论的主要观点；分析图书馆知识资本构成、循环的特点；构建图书馆知识资本循环系统知识转移模型和隐性知识转移机制模型；对图书馆知识资本内部结构和外部结构及其对应的内循环和外循环机制进行分析；揭示了图书馆隐性知识转移机制是系统综合机制。     

Simulation of Three-Dimensional Free-Surface Flows Using Two-Dimensional Multilayer Shallow Water Equations

We present an efficient and conservative Eulerian-Lagrangian method for solving two-dimensional hydrostatic multilayer shallow water flows with mass exchange between the vertical layers. The method consists of a projection finite volume method for the Eulerian stage and a method of characteristics to approximate the numerical fluxes for the Lagrangian stage. The proposed method is simple to implement, satisfies the conservation property and it can be used for multilayer shallow water equations on non-flat bathymetry including eddy viscosity and Coriolis forces. It offers a novel method of calculating stratified vertical velocities without the use of the Navier-Stokes equations. Numerical results are presented for several examples and the obtained results for a free-surface flow problem are in close agreement with the analytical solutions. We also test the performance of the proposed method for a test example of wind-driven flows with recirculation     

Multi-Mesh-Scale Approximation of Thin Geophysical Mass Flows on Complex Topographies

This paper is devoted to a multi-mesh-scale approach for describing the dynamic behaviors of thin geophysical mass flows on complex topographies. Because the topographic surfaces are generally non-trivially curved, we introduce an appropriate local coordinate system for describing the flow behaviors in an efficient way. The complex surfaces are supposed to be composed of a finite number of triangle elements. Due to the unequal orientation of the triangular elements, the distinct flux directions add to the complexity of solving the Riemann problems at the boundaries of the triangular elements. Hence, a vertex-centered cell system is introduced for computing the evolution of the physical quantities, where the cell boundaries lie within the triangles and the conventional Riemann solvers can be applied. Consequently, there are two mesh scales: the element scale for the local topographic mapping and the vertex-centered cell scale for the evolution of the physical quantities. The final scheme is completed by employing the HLL-approach for computing the numerical flux at the interfaces. Three numerical examples and one application to a large-scale landslide are conducted to examine the performance of the proposed approach as well as to illustrate its capability in describing the shallow flows on complex topographies.     

Central and Regional Hemodynamics During the Acute Onset of Renal Hypertension in Rats

The purpose of this study was to quantitate the regional changes in flow and resistance which occur during the acute onset of two-kidney, one clip renal hypertension. Anesthetized rats were implanted with a Doppler flow probe and balloon occluder on one renal artery. To produce acute hypertension, the occluder was inflated to reduce renal flow velocity by 50%. After 90 minutes, mean arterial pressure increased 25% above the prestenosis control period value as a result of a 22% increase in peripheral resistance. Regional flows and resistances were determined prior to and 90 minutes after renal artery stenosis by Injection of labelled microspheres into the left ventricle. Our major findings were that: 1) the regional hemodynamic changes in flow and resistance are unevenly distributed among individual organs; and 2) the major site of increased resistance resides in the splanchnic circulation with the largest increases occurring in the small intestine.     

The application of microbubbles for targeted drug delivery

Interest in microbubbles as vehicles for drug delivery has grown in recent years, due in part to characteristics that make them well suited for this role and in part to the need the for localized delivery of drugs in a number of applications. Microbubbles are inherently small, allowing transvascular passage, they can be functionalized for targeted adhesion, and can be acoustically driven, which facilitates ultrasound detection, production of bioeffects and controlled release of the cargo. This article provides an overview of related microbubble biofluid mechanics and reviews recent developments in the application of microbubbles for targeted drug delivery. Additionally, related advances in non-bubble microparticles for drug delivery are briefly described in the context of targeted adhesion.     

Apport des panneaux Vichy dans l’acquisition de la station assise depuis son utilisation au CAMSP en 2011

The seated position is achieved by the integration of sensory systems and the use of muscle chains to ensure balance and maintenance of the posture against gravity. This position frees the mobility of the upper limbs. Based on the work of Prof. A. Büllinger and his colleagues, which explores the function of sensory flows, particularly peripheral visual flows, in the tonicopostural development of the child, we sought to highlight the importance of the sensory support with which the child with a neuromotor disorder readjusts himself and straightens his back. In a first experiment of specific therapeutic education with gingham panels, we found an immediate, but not permanent, effect of postural straightening when the child is surrounded by these panels, and a long-term effect when they are integrated in the child's physical therapy over a given period. The conclusions drawn from this experiment led us to use gingham panels as a complementary tool in neuromotor therapy within the CAMSP.     

Longitudinal study of lung mechanics in normal infants

Lung mechanics and partial forced expiratory flows were measured serially in seven normal infants during the first year of life. Lung mechanics were measured by the end inspiratory occlusion technique and partial forced expiratory flows by the rapid chest compression method. Thoracic gas volume, compliance, and partial forced expiratory flows measured at functional residual capacity progressively increased with age and correlated with height cubed. Respiratory system resistance progressively fell whereas volume-corrected flows remained fairly constant over the study period. These findings provide longitudinal lung function data and support the concept of isotropic lung growth.