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目的: 检测前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)基因及蛋白在前列腺癌组织中的表达?方法:分别采用半定量RT-PCR法及免疫组织化学法检测52例前列腺癌组织及35例前列腺增生组织中PSMA基因及蛋白的表达情况?结果:①PSMA在前列腺癌及前列腺增生组织中表达阳性率分别为84.6%(44/52)及68.6%(24/35),虽然前列腺癌组织中PSMA表达阳性率高于前列腺增生组织,但两组阳性率间差异无统计学意义(P > 0.05)?PSMA mRNA半定量结果在两组间存在差异,癌组织中PSMA的表达量明显高于增生组织中的表达(P < 0.05)?②前列腺癌组织中PSMA蛋白表达总阳性率高达94.2%,明显高于增生组织中的阳性率(65.7%),且以++~+++居多?结论:PSMA基因及蛋白的表达在前列腺癌组织均高于前列腺增生组织,提示其可作为前列腺癌诊断指标? 相似文献
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The suprasylvian gyrus of cats was systematically mapped by recording acoustic and somatosensory-evoked potentials under pentobarbital and chloralose anaesthesia. In this way two polysensory systems could be differentiated. One of them operates only under chloralose anaesthesia and proved to be identical with the long latency association fields: the anterior middle suprasylvian association area and the posterior middle suprasylvian association area, discovered byThompson,Johnson &Hopes (1963). The other one is localized to the anterior suprasylvian gyrus and exhibits short latency-evoked potentials and is also active under pentobarbital anaesthesia.The incorporation of [3H]-glycine, as demonstrated by autoradiography, showed good correspondence with the electrophysiological findings and so provides a morphological way of localising the two polysensory systems. 相似文献
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Priya H. Dedhia Yasmine White Jonathan R. Dillman Jeremy Adler Marcus D. Jarboe Daniel H. Teitelbaum Ronald B. Hirschl Samir K. Gadepalli 《Journal of pediatric surgery》2018,53(3):477-482
Background and objectives
Sarcopenia, defined as reduced muscle mass, is typically assessed by CT scans, which are infrequently performed in children. Using MRI to measure sarcopenia, we determined the association with postoperative complications after colectomy for ulcerative colitis (UC).Methods
Clinical and preoperative MRI data for 13–18-year-old UC patients who underwent colectomy were retrospectively reviewed. Bilateral paraspinous muscle area (PSMA) and psoas muscle area (PMA) at L3 vertebra were measured and averaged. Composite complications were infection, wound dehiscence, postoperative leak/abscess, prolonged ileus, pulmonary embolism, venous thromboembolism, or readmission.Results
Twenty-nine patients with average age 15.9 ± 1.36 years and weight 61.5 ± 19.8 kg had a preoperative MRI. The 18/29(62%) with complications had significantly reduced PSMA (4.71 ± 1.44 vs 5.64 ± 1.38 cm2, p = 0.04) and PMA (7.16 ± 2.60 vs 8.93 ± 2.44, p = 0.04). When stratified and compared to highest PSMA, patients with lowest PSMA had increased complication rates (88% vs 29%, p = 0.04). There were no differences in age, BMI, albumin, CRP, ESR, or preoperative steroid or anti-TNFα use. Odds of complication in the lowest tertile were 25.0-fold higher than the highest tertile (p = 0.04, 95% CI = 1.2–520.73).Conclusion
This is the first study to show low PSMA on MRI is associated with complications and increased hospital stay after colectomy in children with UC.Levels of evidence
Level III retrospective comparative study. 相似文献
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