蒙医温针治疗赫依偏盛型失眠症的随机对照试验

目的评价蒙医温针治疗赫依偏盛型失眠症的近期疗效及安全性。方法将80例赫依偏盛型失眠症患者随机分为治疗组和对照组各40例。治疗组给予蒙医温针治疗,对照组采用Streitberger针进行安慰剂针刺。观察2组治疗前后失眠严重程度指数(ISI)量表评分及睡眠脑电图的变化情况。结果治疗组治疗前后ISI评分有显著性差异(P<0.05);治疗组治疗后睡眠总时间延长、睡眠潜伏期缩短、睡眠效率相应提高,且睡眠结构有所变化,即N1期睡眠比例减少,REM睡眠比例增多(均P<0.05)。组间比较,除N2期睡眠及N3+N4期睡眠时间无差异,其余睡眠参数差异均具有统计学意义(均P<0.05)。结论蒙医温针可改善赫依偏盛型失眠患者的睡眠质量,调节失眠症患者睡眠结构及睡眠进程,且安全性高。     

尼卡地平对脑缺血后海马CA1锥体神经元的影响

目的　观察尼卡地平对脑缺血后海马CA1锥体神经元的影响。方法　 30只沙土鼠随机分成假手术组 (Ⅰ组 ,n =10 )、缺血组 (Ⅱ组 ,n =10 )和尼卡地平处理组 (Ⅲ组 ,n =10 )。Ⅰ组只进行手术操作 ,不行脑缺血 ;Ⅱ组阻断双侧颈总动脉 15min造成前脑缺血模型 ;Ⅲ组在脑缺血前 30min腹腔注射尼卡地平 2mg/kg体重。 3d后取出动物脑组织 ,HE染色计数海马CA1区 1mm长度内正常锥体细胞数。结果　与Ⅰ组相比 ,Ⅱ组和Ⅲ组正常锥体细胞数明显减少 (P <0 .0 1) ;Ⅱ组的正常锥体细胞数少于Ⅲ组 (P <0 .0 1)。结论　尼卡地平能减轻脑缺血后脑细胞损伤。     

Natural history of extensive Mongolian spots in mucopolysaccharidosis type II (Hunter syndrome): a survey among 52 Japanese patients

BACKGROUND: Recent reports have shown a correlation between extensive Mongolian spots and mucopolysaccharidosis type II (Hunter syndrome). However, a statistical survey of the incidence and natural history of extensive Mongolian spots among the patients with Hunter syndrome is lacking. OBJECTIVES: To determine the prevalence of extensive Mongolian spots, to determine the natural course of the spots according to age in Japanese patients with Hunter syndrome, and to compare them with the results obtained from the patients' brothers who did not have Hunter syndrome. PATIENTS/METHODS: Fifty-two males with Hunter syndrome aged 3 to 40 years were studied. Twenty-five patients were examined in two clinics to determine the existence and characteristics of the spots. We interviewed their families about the spots in their neonates and the natural course of the spots according to their ages. The same survey was done among another 27 patients using a mailed questionnaire to their families. As control, we investigated 21 brothers of the patients by a mailed questionnaire to their families. RESULTS: The extensive Mongolian spots are identified in almost all the infants with Hunter syndrome and disappear extremely later in their life. The lesions had a high incidence of deep-blue hyperpigmentation. Regardless of age, the overall incidence was 78%. All of the brothers who did not have Hunter syndrome had common-type Mongolian spots in neonates, which regressed during their childhood. CONCLUSION: Our results confirm a strong correlation between extensive Mongolian spots and Hunter syndrome for the Japanese population. The presence of extensive Mongolian blue spots should alert the physician to the possibility of Hunter syndrome.     

不同性别长爪沙鼠血液生理生化值的比较

目的:测定长爪沙鼠的血液生理生化正常值,并对两性的正常值进行比较。方法:采血后,用Coulter ACT血球计数仪检测血液生理指标,用日立7170全自动生化分析仪测定血清生化指标,用Beckman CX3生化仪测定血清电解质。结果:血液生理指标中RBC、HCT、HGB、MCH和WBC性别差异有显著性(P<0.05),而MCV、MCHC、RDW、PLT、MPV、PCT和PDW等性别差异无显著性(P>0.05);血清生化指标中ALT和UA性别差异有显著性(P<0.05),而TPROT、GLB、A/G、BUN、CREAT、CHOL、TRIG、ALT和血清电解质(Na+、K+、Cl-、总Ca2+)等均性别差异无显著性(P>0.05)。结论:长爪沙鼠血液的生理生化值受多种因素影响,部分指标两性间测定值有差异,但多数指标差异不显著。     

中国蒙古族新生儿体格发育的研究

１９８８～１９９１年对内蒙古锡盟地区３８９例蒙古族新生儿进行了活体观察测量，取得了２２项总体发育指标及相应的各项性别指标的均值数据，并以其中体重、身长、顶臀长（坐高）、头围、胸围及上臂围等６项指标与国内外有关资料作了比较和性别间的对比分析，从结果来看，体重高于本地区平均水平１１０ｇ，高于国内某些城市１４０～２０２ｇ；身长及坐高分别矮于本地区平均水平５．１３ｃｍ及６．５４ｃｍ，分别矮于国内某些城市４．８８～４．８９ｃｍ及６．６０ｃｍ。呈圆头型、手足宽短、身躯宽短的粗壮体型。     

Synaptosomal Na, K-ATPase during forebrain ischemia in Mongolian gerbils

We studied the activity and kinetic parameters of synaptosomal Na, K-ATPase during 15 min of forebrain ischemia and following 60 min of reperfusion produced by reversible common carotid occlusion in Mongolian gerbils. A synaptosomal fraction was obtained by both differential centrifugation of brain tissue homogenate and centrifugation of crude mitochondrial fraction at a discontinual sucrose density gradient. We found two components of ATP concentration dependence of ATP hydrolysis that represent two types of ATP-binding sites: high affinity and low affinity. Neither ischemia nor reperfusion affected kinetic parameters of a high-affinity site. However, lowaffinity site parameters were affected by both ischemia and ischemia followed by reperfusion. Maximal velocity (V _max) decreased by 43 and 42% after ischemia and after ischemia/reperfusion, respectively. The apparentK _m for ATP decreased by 52% after ischemia and by 47% after ischemia/reperfusion. The apparent affinities for K⁺ and Na⁺ were determined from the ATP hydrolysis rate as a function of Na⁺ and K⁺ concentrations. We found the half-maximal activation constant for K⁺ (K _a K⁺) increased by 60% after ischemia and by 146% after ischemia/reperfusion. On the other hand, we found thatK _aNa⁺ decreased significantly after ischemia/reperfusion (16%). We concluded that it is the dephosphorylation step of the ATPase reation cycle that is primarily affected by both ischemia and ischemia/reperfusion. This might be caused by alteration of the protein molecule and/or its surroundings subsequent to ischemia.     

黄芪丹参复方成分对一氧化氮合成阻滞孕鼠模型血浆IL-1、IL-10变化的影响

目的探讨黄芪丹参复方成分提高胎盘血供的分子机制，为临床有效防治胎盘血供不足所致妊娠并发症提供思路。方法提取分离黄芪、丹参复方成分，运用NOS（一氧化氮合酶）阻滞剂L－精氨酸甲酯（L—NAME）建立一氧化氮合成阻滞大鼠模型，ELISA法检测妊娠18d大鼠血浆IL－1、IL－10水平。以及胎盘超微形态学变化，大鼠血压、尿蛋白变化，以及仔鼠重、肝重、脑重、胎盘重等。结果一氧化氮合成阻滞模型组IL－1含量明显高于空白组（P〈0．01），经黄芪丹参注射液治疗后，血浆IL－1水平比模型组降低（P〈0．05）；模型组IL－10含量较空白组低（P〈0．01），中药组血浆IL－10水平高于模型组（P〈0．05）；胎盘形态学、血压、尿蛋白以及仔重、仔肝重、脑重等均有显著差异（P〈0．05，P〈0．01）。结论黄芪丹参复方成分可能对妊娠早期母－胎界面免疫平衡具有调控作用，通过促进局部生理抑制性免疫反应增强和杀伤、排斥免疫反应减弱，从而有利于母胎循环构建，维持胎盘血液供应。     

医科蒙古族汉族大学生心理健康状况比较研究

目的：了解医科大学生的心理健康状况并进行民族、性别的比较。方法：采用ＳＣＬ－９０量表进行测查并进行统计分析。结果与结论：医科大学生ＳＣＬ－９０各因子均值都高于全国常模，有１９１％的学生存在较严重的心理卫生问题；汉族学生的心理卫生问题较蒙古族学生严重；女生的心理卫生问题较男生严重；人际关系、忧郁、强迫化是医科大学生主要的心理卫生问题。     

蒙古族,汉族新生儿蒙古斑研究

目的：调查蒙古族、汉族、蒙汉后裔新生儿蒙古斑的出现情况。方法：观察蒙古斑的数量、颜色、分布、面积，进行分析。结果与结论：蒙古斑出现率蒙古族为７８．７９％，汉族为７３．５４％，蒙汉后裔为８３．７０％。蒙古斑出现率无性别间差异。蒙古斑多分布于臂部和骶尾部。在有斑者中，人均斑面积为０．００２０ｍ＾２左右，斑面积与体表表面的比值多小于２％。