纽约大学图书馆可重复性研究支持服务的分析及启示

通过网络调查和内容分析，从服务对象、服务内容、人员配置和服务设施等方面对纽约大学图书馆可重复性研究支持服务进行调研分析，并在此基础上总结其服务特点，提出研究型图书馆应积极应对研究领域的“可重复性危机”，倡导开放科学和可重复性研究，加强基础设施建设和开发应用软件，开展嵌入科研过程的可重复性研究培训和咨询，以期为提升研究的可重复性做出贡献。     

可摘局部义齿三维几何学模型库的应用

目的 探讨可摘局部义齿修复体模型库的应用方法。方法 借助PRO／E,POWERSHAPE等软件,合理设计模型库的结构,并探讨快速高效的使用方法。结果 模型库可通过“调用－编辑”和“单元组”的方法应用。结论 该模型库有较合理的组成结构,应用高效,快速。     

牙颌组织及修复体三维几何学、有限元模型的设计

目的 建立口腔修复各类模型及模型库系统。方法 以正常颌骨及牙弓为样本，在CT技术及计算机软件（PRO／E，ANSYS等的）的帮助下，首先建立部分上颌骨及下颌骨的三维几何学模型和有限元模型，再建立牙颌组织和修复体的各类模型库，最后探讨模型和模型库的应用方法。结果 建立了部分上颌骨，下颌骨，牙列及修复体的三维模型及模型库。结论 模型具有较好的力学相似形和几何学相似形，模型库应用高效方便。     

科研院所图书馆下一代服务平台建设的思考

针对信息服务时代科研院所图书馆的信息服务面临专业性要求高、个性化要求高和本地化服务要求高的问题,介绍了下一代图书馆服务平台的发展现状,总结了平台在技术架构、功能特性、运营模式等方面的特征,并结合科研院所图书馆的特点和新一代图书馆服务平台建设案例,提出了符合科研院所图书馆下一代服务平台建设要求的方法和思路。     

做个好的信息导航员 为护理人员服务

目的探讨图书馆员更好地为护理人员服务的工作方法。方法重视护理专业馆藏建设；开展对护理人员的培训；鼓励帮助护理人员撰写论文；传送信息到临床科室。结果护士与图书馆的联系越来越密切。结论图书馆员做好信息导航员，提高了护理人员专业素质，也提高了图书馆馆藏利用率。     

“十四五”期间高校图书馆特色学习空间建设

调研“十四五”期间国内42所高校和加拿大15所高校图书馆的特色学习空间建设现状,对比分析国内外高校图书馆学习空间差异,并为我国高校图书馆特色学习空间建设提供发展思路,提出了建设特色化学习空间、深化空间服务内容、强化空间服务团队建设、建立完善的学习空间预约制度等特色学习空间建设途径。     

Proteomic Analysis for Finding Serum Pathogenic Factors and Potential Biomarkers in Multiple Myeloma

Background:

Multiple myeloma (MM) is a malignant tumor, which takes the second place in malignant blood disease. The clinical symptoms are complicated that make more difficult to diagnose and therapy. Lots of researches focus on the proteins about MM in order to solve those problems. We used proteomic methods to find potential biomarkers in MM patients.

Methods:

We applied the peptide ligand library beads (PLLBs) to deplete high abundance proteins in serum for finding potential pathogenic factors and biomarkers of MM. Using 1D-Gel-liquid chromatography-tandem mass spectrometry (LC-MS/MS), we identified 789 and 849 unique serum proteins in MM patients and in healthy controls, respectively.

Results:

Twenty-two proteins were found differentially expressed between the two groups including serum amyloid A protein, vitamin D-binding protein isoform-1 precursor, plasma kallikrein, and apolipoprotein A-I. Changes of integrin alpha-11 and isoform-1 of multimerin-1 were validated with Western blotting. The linkage of the differentially expressed proteins and the pathogenesis pathways of MM were discussed.

Conclusions:

PLLB combined with 1D-gel-LC-MS/MS analysis is an efficient method to identify differentially expressed proteins in serum from patients with MM.     

Automation and developmental validation of the ForenSeq™ DNA Signature Preparation kit for high-throughput analysis in forensic laboratories

Massively parallel sequencing (MPS) applications in forensic science highlight the advantages of this technique compared to capillary electrophoresis (CE). The multiplexing of a wide range of genetic markers and access to the full amplicon sequence, allowing the detection of isoalleles, make it a very promising tool which could be applied to the most challenging casework DNA samples. However, the complexity of the manual library preparation protocol, potential DNA contamination and sample tracking issues are the main reasons why forensic scientists still hesitate to implement MPS analytical workflows in their laboratory. Here, we present the automation of all library preparation steps for up to 96 samples using the Verogen’s ForenSeq^™ DNA Signature Preparation kit. This automated protocol, developed on a Hamilton ID STARlet robotic platform, is designed to allow the combined sequencing of rich and poor DNA samples thanks to a final step which adjusts normalized library pooling volume to guarantee a uniform depth of coverage across all samples. Our study includes tests of concordance, repeatability, reproducibility and sensitivity (1000 pg, 700 pg, 500 pg, 250 pg, 100 pg and 50 pg). Sequencing results obtained with the automated protocol were found to be concordant with previous validation studies using the manual protocol in terms of depth of coverage and allele coverage ratio. The results of this study will assist forensic laboratories seeking to acquire a plug and play solution to optimize the processing and analysis of casework samples with MPS.     

NLM在卫生信息化建设中的作用

对美国国立医学图书馆(NLM)在卫生信息化建设中所发挥的独特功能进行阐述,包括建立生物医学相关数据库、卫生数据标准制定、医学知识库构建、教育与培训等方面,指出医学图书馆在信息化建设进程中有其自身的优势。     

Free Online Consumer Health Classes

Abstract

The National Library of Medicine (NLM) provides many avenues for consumers to find and evaluate online health information. In addition to the consumer health Web sites NLM has developed, there are numerous online training modules available through The National Network of Libraries of Medicine's “National Training Center and Clearinghouse's Educational Database.” This database lists available classes and provides contact information for libraries across the country that offer training and education in using the NLM Web sites and in finding and evaluating health information online.