首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   8612篇
  免费   695篇
  国内免费   69篇
耳鼻咽喉   61篇
儿科学   93篇
妇产科学   103篇
基础医学   884篇
口腔科学   123篇
临床医学   987篇
内科学   630篇
皮肤病学   95篇
神经病学   800篇
特种医学   86篇
外科学   568篇
综合类   1410篇
预防医学   2509篇
眼科学   106篇
药学   389篇
  17篇
中国医学   340篇
肿瘤学   175篇
  2024年   4篇
  2023年   167篇
  2022年   276篇
  2021年   400篇
  2020年   392篇
  2019年   327篇
  2018年   379篇
  2017年   321篇
  2016年   280篇
  2015年   278篇
  2014年   702篇
  2013年   741篇
  2012年   633篇
  2011年   668篇
  2010年   500篇
  2009年   448篇
  2008年   478篇
  2007年   536篇
  2006年   388篇
  2005年   294篇
  2004年   219篇
  2003年   194篇
  2002年   129篇
  2001年   99篇
  2000年   78篇
  1999年   70篇
  1998年   52篇
  1997年   26篇
  1996年   30篇
  1995年   38篇
  1994年   17篇
  1993年   23篇
  1992年   21篇
  1991年   20篇
  1990年   22篇
  1989年   15篇
  1988年   14篇
  1987年   11篇
  1986年   15篇
  1985年   13篇
  1984年   16篇
  1983年   13篇
  1982年   5篇
  1981年   2篇
  1980年   3篇
  1979年   3篇
  1978年   6篇
  1974年   5篇
  1970年   1篇
  1969年   2篇
排序方式: 共有9376条查询结果,搜索用时 15 毫秒
1.
目的研究异牡荆素(ISO)对非小细胞性肺癌(NSCLC)细胞的影响和潜在的机制。方法将A549和H1650细胞分别分为空白组、低剂量实验组(4μmol·L-1 ISO)和高剂量实验组(16μmol·L-1 ISO)。用噻唑蓝法检测NSCLC细胞活性,用肿瘤球形成实验检测NSCLC细胞的细胞球形成率,用Western blot法检测NSCLC细胞凋亡、自我更新、无翅型MMTV整合位点家族/β-连环蛋白(Wnt/β-catenin)信号通路相关蛋白的表达水平。结果与空白组比较,低、高剂量实验组中A549和H1650细胞在24,48和72 h的细胞活性均显著降低。低、高剂量实验组和空白组中A549细胞的细胞球形成率分别为(4.18±0.45)%,(2.01±0.67)%和(6.02±0.57)%,切割的半胱氨酸蛋白酶-3相对表达量分别为0.24±0.08,1.25±0.13和0.06±0.07,SRY相关高迁移率族盒蛋白-2相对表达量分别为0.49±0.04,0.25±0.03和1.00±0.09,Kruppel样因子4相对表达量分别为0.68±0.04,0.44±0.03和1.01±0.06,Wnt1相对表达量分别为0.63±0.06,0.28±0.04和1.00±0.06,β-catenin相对表达量分别为0.41±0.05,0.22±0.03和1.01±0.09;与空白组比较,低、高剂量实验组中A549细胞的上述指标的差异均有统计学意义(P<0.05,P<0.01)。上述3组中H1650细胞的上述指标也呈现一致的现象。结论ISO可能通过抑制Wnt/β-catenin信号通路来抑制NSCLC细胞活性和自我更新,并促进其凋亡。  相似文献   
2.
ObjectivesSeveral implementation strategies can reduce potentially inappropriate medication (PIM) prescribing. Although use of PIMs has declined in recent years, it remains prevalent. Various strategies exist to improve the appropriateness of medication use. However, little is known about the processes of these different implementation strategies. This scoping review aims to investigate how the process evaluation of implementation strategies for reducing PIM prescribing in the older population has been studied.MethodsWe searched for process evaluations of implementation strategies for reducing PIM prescribing in PUBMED, SCOPUS and Web of Science published between January 2000 and November 2019 in English. We applied the following inclusion criteria: patients aged ≥65 years, validated PIM criteria, and implementation process evaluated. The review focuses on decision support for health care professionals. We described the findings of the process evaluations, and compared the authors’ concepts of process evaluation of the included publications to those of Proctor et al.( 2010).ResultOf 9131 publications screened, 29 met our inclusion criteria. Different process evaluation conceptualizations were identified. Most process evaluations took place in the initial stages of the process (acceptability, adoption, appropriateness, and feasibility) and sustainability and implementation costs were seldom evaluated. None of the included publications evaluated fidelity.Multifaceted interventions were the most studied implementation strategies. Medication review was more common in acceptability evaluations, multidisciplinary interventions in adoption evaluations, and computerized systems and educational interventions in feasibility evaluations. Process evaluations were studied from the health care professionals’ viewpoint in most of the included publications, but the management viewpoint was missing.DiscussionThe conceptualization of process evaluation in the field of PIM prescribing is indeterminate. There is also a current gap in the knowledge of sustainability and implementation costs. Clarifying the conceptualization of implementation process evaluation is essential in order to effectively translate research knowledge into practice.  相似文献   
3.
胡依    闵淑慧  郭芮绮  成晓芬  李贝 《现代预防医学》2022,(22):4112-4118
目的 了解流动老人基本公共卫生服务利用情况,以及社会融合对基本公共卫生服务利用的影响。方法 于2021年7—12月,采用方便抽样的方法,抽取广州市、深圳市、江门市452名流动老人进行问卷调查。采用二元logistic回归模型分析流动老人社会融合对建立健康档案、接受健康教育和老年人健康管理之间的影响。结果 在452名流动老人中,60.8%建立了居民健康档案,接受过健康教育和老年人健康管理的分别有64.4%和60.0%。Logistic分析结果显示,流动老人的居民健康档案行为受到月消费水平(B = 0.368,P<0.05)、社区文体活动参与程度(B = 0.362,P<0.01)、居留意愿(B = 0.408,P<0.001)、年龄(B = - 0. 513,P<0.01)、户籍类型(B = 0.742,P<0.01)、流动类型(B = - 0.539,P<0.05)等变量的影响;健康教育服务利用行为受到社区文体活动参与程度(B = 0.354,P<0.01)、年龄(B = - 0.411,P<0.05)、户籍类型(B = 0.561,P<0.05)的影响;老年人健康管理服务利用行为受到社区文体活动参与程度(B = 0.291,P<0.01)、居留意愿(B = 0.239,P<0.05)、年龄(B = - 0.474,P<0.05)、流动类型(B = - 0.471,P<0.05)、流动时间(B = 0.225,P<0.05)、流动目的(B = 0.328,P<0.01)的影响。结论 流动老人基本公共卫生服务利用率较低,社会融合会对流动老人的基本公共卫生服务利用产生积极影响。可以通过提高流动老人获得基本公共卫生服务的能力和社会融合水平来促进流动老人的基本公共卫生服务利用,从而实现基本公共服务均等化。  相似文献   
4.
ObjectiveThe aim of this scoping review was to investigate the published literature on written assessment of communication skills in health professionals’ education.MethodsPubmed, Embase, Cinahl and Psychnfo were screened for the period 1/1995–7/2020. Selection was conducted by four pairs of reviewers. Four reviewers extracted and analyzed the data regarding study, instrument, item, and psychometric characteristics.ResultsFrom 20,456 assessed abstracts, 74 articles were included which described 70 different instruments. Two thirds of the studies used written assessment to measure training effects, the others focused on the development/validation of the instrument. Instruments were usually developed by the authors, often with little mention of the test development criteria. The type of knowledge assessed was rarely specified. Most instruments included clinical vignettes. Instrument properties and psychometric characteristics were seldom reported.ConclusionThere are a number of written assessments available in the literature. However, the reporting of the development and psychometric properties of these instruments is often incomplete. Practice implications written assessment of communication skills is widely used in health professions education. Improvement in the reporting of instrument development, items and psychometrics may help communication skills teachers better identify when, how and for whom written assessment of communication should be used.  相似文献   
5.
【目的】 探索医学期刊的知识服务实践,为医学期刊的科学传播创新提供参考。【方法】 以《中华医学杂志》为研究对象,采用案例研究法和文献分析法进行系统研究。【结果】 借助继续医学教育、微信平台、重要文章发布会、数据库,以及优先出版、按需出版、开放阅读等方式,《中华医学杂志》打造多元化场景的知识服务、联结传播渠道,从而使得科学共同体和公众读者获得较好的知识服务体验。【结论】 医学期刊的知识服务实践应以科学传播为宗旨,在实现增值服务的同时,推进科学知识在科学共同体和普通读者间的传播。  相似文献   
6.
BackgroundBreastfeeding has several benefits for both the infants and mothers. This study assessed breastfeeding knowledge, attitudes, and practices (KAP) among mothers of infants with Retinopathy of Prematurity (ROP).MethodsA cross-sectional study was conducted among mothers of infants with ROP visiting the ROP clinic in a selected tertiary care centre. A total of 100 mothers were selected through the convenience sampling method and interviewed using a structured questionnaire.ResultA significant number of mothers had average to poor knowledge (81%) with a mean score of 8.32 ± 2.7. More than half of the mothers had poor practices related to breastfeeding with a mean score of 7.6 ± 2.4. The attitudes of the mothers towards breastfeeding was either neutral or positive towards formula feeding.ConclusionThe KAPs of mothers regarding breastfeeding were inadequate. Intervention measures are recommended for promoting breastfeeding practices among the mothers of infants with ROP.  相似文献   
7.
ObjectiveTo investigate the knowledge and management of Relative Energy Deficiency in Sport (RED-S), from the perspective of lightweight rowers and physiotherapists.DesignSemi-structured individual qualitative interviews.MethodsPhysiotherapists who had worked with lightweight rowers, and current and former lightweight rowers (who had experienced at least one symptom of RED-S), undertook audio-recorded semi-structured telephone interviews. An inductive thematic analysis was performed, facilitated by NVivo software.ResultsTwelve physiotherapists (n = 6 females, 1–20 years of experience managing lightweight rowers) and twelve lightweight rowers (n = 8 females, 1–8 years lightweight rowing experience, intermediate to elite/international level) were interviewed. Five key themes were identified: insufficient knowledge of RED-S, inadequate RED-S education, inappropriate management of RED-S, referral to other health professionals, prioritising performance over health. Participants provided suggestions for improving knowledge and management of RED-S in lightweight rowers, including formal physiotherapy education and training, and targeted education for athletes and coaches.ConclusionsThere was a significant lack of awareness of RED-S amongst physiotherapists and lightweight rowers. Most physiotherapists were not confident discussing or managing RED-S in athletes, and lightweight rowers were dissatisfied with the management they received. Improving RED-S education for physiotherapists and athletes may have important health implications for lightweight rowers.  相似文献   
8.
9.
BackgroundHeadache disorders are highly prevalent worldwide. Many headache sufferers search for answers outside medical and pharmaceutical models. Complementary and alternative medicine (CAM) including osteopathy are widely used by headache patients. Indeed 9% of patients consulting osteopaths do so for headaches. There is no existing assessment of headache knowledge among practising Osteopaths in the UK.MethodsThis study was a cross-sectional survey employing an anonymous online questionnaire. An original questionnaire was developed. The scope was based on established guidelines in the primary care setting. Multiple choice and closed-ended questions assessed knowledge of the diagnostic criteria, potential red flags and appropriate investigations. The answers were informed by the International Classification Headache Disorder (ICHD-3) and the British Association for the Study of Headaches (BASH) guidelines. Three case vignettes relevant to osteopathic practice were included. Participants were invited to give optional free text feedback. The questionnaire was open to be self-completed by participants for 30 days.ResultsThere were 398 responders of which 383 were included and all of whom completed the questionnaire. The study found areas where knowledge was good, areas where it was limited and areas of uncertainty. The mean knowledge score was 6.93 out of 10 (range 2.18–9.42). There was a significantly lower mean knowledge score in those who had no prior headache education of −0.716 with a difference in means (−1.075 to −0.353, 95% C.I.) compared to those with prior education. Gender and years qualified had no significant effect on mean knowledge score. Optional free text feedback was given by 81 (21.2%) of the respondents and analyzed. The main themes were acknowledgment of knowledge gaps and a desire for more headache education.ConclusionThe findings suggest there are gaps in the existing knowledge on headache among UK osteopaths and the extent of this is dependent on prior headache education. We propose that ongoing headache education among osteopaths is needed in the field.  相似文献   
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号