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排序方式: 共有9376条查询结果,搜索用时 15 毫秒
1.
目的研究异牡荆素(ISO)对非小细胞性肺癌(NSCLC)细胞的影响和潜在的机制。方法将A549和H1650细胞分别分为空白组、低剂量实验组(4μmol·L-1 ISO)和高剂量实验组(16μmol·L-1 ISO)。用噻唑蓝法检测NSCLC细胞活性,用肿瘤球形成实验检测NSCLC细胞的细胞球形成率,用Western blot法检测NSCLC细胞凋亡、自我更新、无翅型MMTV整合位点家族/β-连环蛋白(Wnt/β-catenin)信号通路相关蛋白的表达水平。结果与空白组比较,低、高剂量实验组中A549和H1650细胞在24,48和72 h的细胞活性均显著降低。低、高剂量实验组和空白组中A549细胞的细胞球形成率分别为(4.18±0.45)%,(2.01±0.67)%和(6.02±0.57)%,切割的半胱氨酸蛋白酶-3相对表达量分别为0.24±0.08,1.25±0.13和0.06±0.07,SRY相关高迁移率族盒蛋白-2相对表达量分别为0.49±0.04,0.25±0.03和1.00±0.09,Kruppel样因子4相对表达量分别为0.68±0.04,0.44±0.03和1.01±0.06,Wnt1相对表达量分别为0.63±0.06,0.28±0.04和1.00±0.06,β-catenin相对表达量分别为0.41±0.05,0.22±0.03和1.01±0.09;与空白组比较,低、高剂量实验组中A549细胞的上述指标的差异均有统计学意义(P<0.05,P<0.01)。上述3组中H1650细胞的上述指标也呈现一致的现象。结论ISO可能通过抑制Wnt/β-catenin信号通路来抑制NSCLC细胞活性和自我更新,并促进其凋亡。 相似文献
2.
《Research in social & administrative pharmacy》2022,18(3):2367-2391
ObjectivesSeveral implementation strategies can reduce potentially inappropriate medication (PIM) prescribing. Although use of PIMs has declined in recent years, it remains prevalent. Various strategies exist to improve the appropriateness of medication use. However, little is known about the processes of these different implementation strategies. This scoping review aims to investigate how the process evaluation of implementation strategies for reducing PIM prescribing in the older population has been studied.MethodsWe searched for process evaluations of implementation strategies for reducing PIM prescribing in PUBMED, SCOPUS and Web of Science published between January 2000 and November 2019 in English. We applied the following inclusion criteria: patients aged ≥65 years, validated PIM criteria, and implementation process evaluated. The review focuses on decision support for health care professionals. We described the findings of the process evaluations, and compared the authors’ concepts of process evaluation of the included publications to those of Proctor et al.( 2010).ResultOf 9131 publications screened, 29 met our inclusion criteria. Different process evaluation conceptualizations were identified. Most process evaluations took place in the initial stages of the process (acceptability, adoption, appropriateness, and feasibility) and sustainability and implementation costs were seldom evaluated. None of the included publications evaluated fidelity.Multifaceted interventions were the most studied implementation strategies. Medication review was more common in acceptability evaluations, multidisciplinary interventions in adoption evaluations, and computerized systems and educational interventions in feasibility evaluations. Process evaluations were studied from the health care professionals’ viewpoint in most of the included publications, but the management viewpoint was missing.DiscussionThe conceptualization of process evaluation in the field of PIM prescribing is indeterminate. There is also a current gap in the knowledge of sustainability and implementation costs. Clarifying the conceptualization of implementation process evaluation is essential in order to effectively translate research knowledge into practice. 相似文献
3.
目的 了解流动老人基本公共卫生服务利用情况,以及社会融合对基本公共卫生服务利用的影响。方法 于2021年7—12月,采用方便抽样的方法,抽取广州市、深圳市、江门市452名流动老人进行问卷调查。采用二元logistic回归模型分析流动老人社会融合对建立健康档案、接受健康教育和老年人健康管理之间的影响。结果 在452名流动老人中,60.8%建立了居民健康档案,接受过健康教育和老年人健康管理的分别有64.4%和60.0%。Logistic分析结果显示,流动老人的居民健康档案行为受到月消费水平(B = 0.368,P<0.05)、社区文体活动参与程度(B = 0.362,P<0.01)、居留意愿(B = 0.408,P<0.001)、年龄(B = - 0. 513,P<0.01)、户籍类型(B = 0.742,P<0.01)、流动类型(B = - 0.539,P<0.05)等变量的影响;健康教育服务利用行为受到社区文体活动参与程度(B = 0.354,P<0.01)、年龄(B = - 0.411,P<0.05)、户籍类型(B = 0.561,P<0.05)的影响;老年人健康管理服务利用行为受到社区文体活动参与程度(B = 0.291,P<0.01)、居留意愿(B = 0.239,P<0.05)、年龄(B = - 0.474,P<0.05)、流动类型(B = - 0.471,P<0.05)、流动时间(B = 0.225,P<0.05)、流动目的(B = 0.328,P<0.01)的影响。结论 流动老人基本公共卫生服务利用率较低,社会融合会对流动老人的基本公共卫生服务利用产生积极影响。可以通过提高流动老人获得基本公共卫生服务的能力和社会融合水平来促进流动老人的基本公共卫生服务利用,从而实现基本公共服务均等化。 相似文献
4.
《Patient education and counseling》2022,105(5):1188-1200
ObjectiveThe aim of this scoping review was to investigate the published literature on written assessment of communication skills in health professionals’ education.MethodsPubmed, Embase, Cinahl and Psychnfo were screened for the period 1/1995–7/2020. Selection was conducted by four pairs of reviewers. Four reviewers extracted and analyzed the data regarding study, instrument, item, and psychometric characteristics.ResultsFrom 20,456 assessed abstracts, 74 articles were included which described 70 different instruments. Two thirds of the studies used written assessment to measure training effects, the others focused on the development/validation of the instrument. Instruments were usually developed by the authors, often with little mention of the test development criteria. The type of knowledge assessed was rarely specified. Most instruments included clinical vignettes. Instrument properties and psychometric characteristics were seldom reported.ConclusionThere are a number of written assessments available in the literature. However, the reporting of the development and psychometric properties of these instruments is often incomplete. Practice implications written assessment of communication skills is widely used in health professions education. Improvement in the reporting of instrument development, items and psychometrics may help communication skills teachers better identify when, how and for whom written assessment of communication should be used. 相似文献
5.
【目的】 探索医学期刊的知识服务实践,为医学期刊的科学传播创新提供参考。【方法】 以《中华医学杂志》为研究对象,采用案例研究法和文献分析法进行系统研究。【结果】 借助继续医学教育、微信平台、重要文章发布会、数据库,以及优先出版、按需出版、开放阅读等方式,《中华医学杂志》打造多元化场景的知识服务、联结传播渠道,从而使得科学共同体和公众读者获得较好的知识服务体验。【结论】 医学期刊的知识服务实践应以科学传播为宗旨,在实现增值服务的同时,推进科学知识在科学共同体和普通读者间的传播。 相似文献
6.
《Journal of neonatal nursing : JNN》2022,28(5):361-364
BackgroundBreastfeeding has several benefits for both the infants and mothers. This study assessed breastfeeding knowledge, attitudes, and practices (KAP) among mothers of infants with Retinopathy of Prematurity (ROP).MethodsA cross-sectional study was conducted among mothers of infants with ROP visiting the ROP clinic in a selected tertiary care centre. A total of 100 mothers were selected through the convenience sampling method and interviewed using a structured questionnaire.ResultA significant number of mothers had average to poor knowledge (81%) with a mean score of 8.32 ± 2.7. More than half of the mothers had poor practices related to breastfeeding with a mean score of 7.6 ± 2.4. The attitudes of the mothers towards breastfeeding was either neutral or positive towards formula feeding.ConclusionThe KAPs of mothers regarding breastfeeding were inadequate. Intervention measures are recommended for promoting breastfeeding practices among the mothers of infants with ROP. 相似文献
7.
ObjectiveTo investigate the knowledge and management of Relative Energy Deficiency in Sport (RED-S), from the perspective of lightweight rowers and physiotherapists.DesignSemi-structured individual qualitative interviews.MethodsPhysiotherapists who had worked with lightweight rowers, and current and former lightweight rowers (who had experienced at least one symptom of RED-S), undertook audio-recorded semi-structured telephone interviews. An inductive thematic analysis was performed, facilitated by NVivo software.ResultsTwelve physiotherapists (n = 6 females, 1–20 years of experience managing lightweight rowers) and twelve lightweight rowers (n = 8 females, 1–8 years lightweight rowing experience, intermediate to elite/international level) were interviewed. Five key themes were identified: insufficient knowledge of RED-S, inadequate RED-S education, inappropriate management of RED-S, referral to other health professionals, prioritising performance over health. Participants provided suggestions for improving knowledge and management of RED-S in lightweight rowers, including formal physiotherapy education and training, and targeted education for athletes and coaches.ConclusionsThere was a significant lack of awareness of RED-S amongst physiotherapists and lightweight rowers. Most physiotherapists were not confident discussing or managing RED-S in athletes, and lightweight rowers were dissatisfied with the management they received. Improving RED-S education for physiotherapists and athletes may have important health implications for lightweight rowers. 相似文献
8.
9.
BackgroundHeadache disorders are highly prevalent worldwide. Many headache sufferers search for answers outside medical and pharmaceutical models. Complementary and alternative medicine (CAM) including osteopathy are widely used by headache patients. Indeed 9% of patients consulting osteopaths do so for headaches. There is no existing assessment of headache knowledge among practising Osteopaths in the UK.MethodsThis study was a cross-sectional survey employing an anonymous online questionnaire. An original questionnaire was developed. The scope was based on established guidelines in the primary care setting. Multiple choice and closed-ended questions assessed knowledge of the diagnostic criteria, potential red flags and appropriate investigations. The answers were informed by the International Classification Headache Disorder (ICHD-3) and the British Association for the Study of Headaches (BASH) guidelines. Three case vignettes relevant to osteopathic practice were included. Participants were invited to give optional free text feedback. The questionnaire was open to be self-completed by participants for 30 days.ResultsThere were 398 responders of which 383 were included and all of whom completed the questionnaire. The study found areas where knowledge was good, areas where it was limited and areas of uncertainty. The mean knowledge score was 6.93 out of 10 (range 2.18–9.42). There was a significantly lower mean knowledge score in those who had no prior headache education of −0.716 with a difference in means (−1.075 to −0.353, 95% C.I.) compared to those with prior education. Gender and years qualified had no significant effect on mean knowledge score. Optional free text feedback was given by 81 (21.2%) of the respondents and analyzed. The main themes were acknowledgment of knowledge gaps and a desire for more headache education.ConclusionThe findings suggest there are gaps in the existing knowledge on headache among UK osteopaths and the extent of this is dependent on prior headache education. We propose that ongoing headache education among osteopaths is needed in the field. 相似文献
10.