Tape stripping of human stratum corneum yields cell layers that originate from various depths because of furrows in the skin

Received: 21 November 1996     

Epidermal injury stimulates prenylation in the epidermis of hairless mice

Isoprenylation is the covalent attachment of isoprenyl groups, intermediates of the cholesterol biosynthesis pathway, to carboxy terminal cysteine residues of proteins. Numerous proteins are isoprenylated including small GTP binding proteins, trimeric G proteins, and nuclear lamins, and these prenylated proteins regulate a variety of cell functions, including cell growth, cytokinesis, and differentiation. Here, we quantitated protein prenylation and determined which proteins are prenylated in the epidermis of hairless mice by radiolabeling with ³ H-mevalonolactone following acute or chronic epidermal injury. In normal epidermis, four major radiolabeled bands, with molecular weights of 17–26, 48, 54, and 68 kDa, were observed. The levels of each of these bands increased by 24–63% 16 h following acute epidermal injury induced by topical acetone treatment or tape stripping, returning to normal by 24 h. On 2D gel electrophoresis, there were no major differences between the patterns of labeling following barrier disruption. Subacute epidermal injury induced by either acetone or tape stripping twice a day for 7 days and chronic injury induced by feeding an essential fatty acid-deficient (EFAD) diet, also resulted in a significant increase in protein prenylation. As with acute injury, SDS-PAGE and 2D gel electrophoresis did not reveal marked differences in the pattern of protein prenylation. These results demonstrate that the prenylation of proteins in the epidermis is stimulated by injury, suggesting that one or more of these prenylated species may be important in epidermal proliferation or differentiation. Received: 29 May 1996     

Dual function of Langerhans cells in skin TSLP-promoted TFH differentiation in mouse atopic dermatitis

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The effects of kinesio taping on the color intensity of superficial skin hematomas: A pilot study

ObjectivesTo analyze the effects of kinesio taping (KT) -applied with three different strains that induced or not the formation of skin creases (called convolutions)- on color intensity of post-surgical superficial hematomas.DesignSingle-blind paired study.SettingRehabilitation clinic.ParticipantsA convenience sample of 13 inpatients with post-surgical superficial hematomas.InterventionsThe tape was applied for 24 consecutive hours. Three tails of KT were randomly applied with different degrees of strain: none (SN); light (SL); and full longitudinal stretch (SF). We expected to obtain correct formation of convolutions with SL, some convolutions with SN, and no convolutions with SF.Main outcome measuresThe change in color intensity of hematomas, measured by means of polar coordinates CIE L*a*b* using a validated and standardized digital images system.ResultsApplying KT to hematomas did not significantly change the color intensity in the central area under the tape (p > 0.05). There was a significant treatment effect (p < 0.05) under the edges of the tape, independently of the formation of convolutions (p > 0.05).ConclusionsThe changes observed along the edges of the tape could be related to the formation of a pressure gradient between the KT and the adjacent area, but were not dependent on the formation of skin convolutions.     

What is the effect of treating secondary lymphedema after breast cancer with complete decongestive physiotherapy when the bandage is replaced with Kinesio Textape? – A pilot study

Purpose: Secondary lymphedema (SL) following breast cancer is a well-known complication following surgery or radiation. SL may result in loss of functional ability, cosmetic deformities, physical discomfort, recurrent episodes of erysipelas, and psychological distress. There is no evidence as to what is the most effective treatment for SL. Methods: This randomized controlled pilot study included 10 patients treated for SL following breast cancer. The patients were included and screened for SL by a physiotherapist. They were randomized to treatment with CDP with Kinesio Textape or bandage for 4 weeks. Endpoints were quality of life, circumference of the arm, costs, and working environment for the physiotherapist. Results: The two groups were comparable according to baseline data. Outcomes on quality of life, costs, and working environment for the physiotherapist; the treatment with CDP with tape was superior to the CDP with bandage treatment. In regard to reducing the circumference there was no difference. Conclusions: This randomized controlled pilot study shows that CDP with tape can be an alternative to CDP with bandage. The quality of life is higher, the economy and working environment is better, and the effect measured by circumference is comparable. More RCTs are required to increase the evidence for CDP with tape. Implications: Treating lymphedema with CDP with tape after breast cancer is a good alternative to CDP with bandage and makes it possible to treat more patients with less resources.     

Can kinesio tape be used as an ankle training method in the rehabilitation of the stroke patients?

ObjectiveTo investigate the effects of the kinesio tape application to the tibialis anterior on rehabilitation outcomes of the stroke patients.Design and settingTwenty patients with stroke were allocated into two groups: the first group of ten patients was assigned to receive kinesio tape in addition to the conventional rehabilitation program while a second group of 10 patients was assigned to receive a conventional rehabilitation program only.Main outcome measuresThe clinical variables and health-related quality of life (HRQoL) were evaluated at baseline and at the end of the forth week.ResultsThe present study showed that kinesio tape application to the tibialis anterior has significant effects on motor recovery of the lower extremity, spasticity, ambulation capacity, HRQoL and gait compared to the control group and baseline.ConclusionsThe results of this study suggest that kinesio tape can be used as an ankle training method.     

Effects of Kinesio tape application to trunk isokinetic strength in female participants

ABSTRACT

The purpose of this study is to analyse the effects of KT on trunk strength with respect to different angular speeds when applied to the trunks of healthy women. Forty healthy female participants were randomly distributed into two groups: the placebo group (PG) in which placebo KT was applied and the experimental group (EG). Participants’ trunk concentric flexion and extension muscle strength were measured using an isokinetic dynamometer in two different angular speeds (60°/s ? 180°/s). In both PG and EG groups, there was no significant difference measured immediately after taping at the two angular speed values. In the measurements taken 48 h later, as regards PG trunk flexion, extension muscle strength increased significantly (p = 0.0001) at 60°/sc. angular speed while, for the EG only, the strength of trunk extension muscle increased significantly (p = 0.002). It was observed, that to ensure an increase in strength, waiting for a certain length of time was required. Lower angular speeds and short-term applied KT improved the strength of the trunk extension muscle.     

The late effect of Kinesio Taping® on handgrip strength

Kinesio Taping^® elastic tape is increasingly used in physiotherapy treatment. However, there is a lack of scientific research regarding the late effects of its use. This study quantified the late effects of applying the Kinesio Taping^® elastic tape by measuring changes in handgrip muscle strength after 24, 48 and 72 h of application. The Kinesio Taping^® elastic tape was applied on the dominant and non-dominant limbs of 36 volunteers randomly assigned to three groups: muscle facilitation, muscle inhibition and control group. The statistical test showed there was a statistically significant difference among all groups of dominant limb and non-dominant limb. However, the analysis on intragroup relationship to periods of application (Initial, 24, 48 and 72 h) and the interaction among repeated measures showed there was no statistically significant difference. This result may contribute to the investigation of the late effects of the Kinesio Taping^® elastic tape on the physical rehabilitation.     

软组织贴扎技术对老年膝关节内侧副韧带损伤后的康复疗效观察

目的观察软组织贴扎技术治疗老年患者膝关节内侧副韧带损伤后膝关节功能障碍的康复疗效果,为治疗该病提供方法。方法选择2019年5月-2020年12月于上海市仁济医院宝山分院康复治疗科和骨科就诊的老年患者共52例,采用随机数字表随机分为2组:试验组(n=27)和对照组(n=25)。对照组采取常规康复治疗,试验组在与对照组相同的常规康复治疗基础上,加用软组织贴扎技术治疗。检测并比较2组治疗前后VAS疼痛评分和Lysholm膝关节评分。结果治疗前,2组VAS疼痛评分和Lysholm膝关节评分均差异无统计学意义(P>0.05)。治疗后,2组VAS分值均明显低于同组治疗前(P<0.05),Lysholm分值均明显高于同组治疗前(P<0.05);且试验组VAS分值明显低于对照组,而Lysholm分值明显高于对照组,差异均有统计学意义(P<0.05)。结论在常规康复治疗基础上增加软组织贴扎技术治疗,可有效缓解老年膝关节内侧副韧带损伤患者疼痛,促进膝关节功能的恢复,具有一定的临床应用价值。     

肌内效贴对新生儿上干型分娩性臂丛神经损伤的疗效分析

目的：评价肌内效贴治疗新生儿上干型分娩性臂丛神经损伤的临床疗效,为其临床治疗提供部分参考依据。方法：新生儿上干型分娩性臂丛神经损伤的患儿22例,随机分为肌贴组和对照组各11例,对照组进行常规康复治疗,肌贴组在常规康复治疗的基础上增加并全程接受肌内效贴治疗。2组分别在治疗前后测试臂丛功能综合评价、粗大运动功能测试A区(GMFM-A)评分以及神经肌电图检测腋神经、肌皮神经、正中神经的复合动作电位波幅值。结果：2组患儿在治疗3个月后,测试结果均优于治疗前测试结果(P<0.05)。治疗3个月后,肌贴组患儿臂丛功能综合评价、GMFM-A得分优于对照组(P<0.05)。肌贴组的肌电图检查显示腋神经、肌皮神经、正中神经的复合肌肉动作电位波幅明显高于对照组(P<0.05)。结论：肌内效贴对新生儿上干型分娩性臂丛神经损伤的上肢功能的恢复有良好的效果,有一定的临床借鉴意义。