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1.
ABSTRACT BACKGROUND Hepatitis-associated aplastic anemia (HAAA) is a rare condition. Patients with HAAA usually present with acute hepatitis, jaundice and significantly increased transaminase. After 1–2 mo, hepatitis gradually improves, but progressive hemocytopenia, bone marrow hematopoietic failure, and severe or extremely severe aplastic anemia are manifest. Most cases of HAAA are fulminant and usually lethal if left untreated. The literature on Epstein–Barr virus (EBV)-associated HAAA is sparse. CASE SUMMARY We report a 30-year-old man who was admitted to our hospital because of pale yellow urine and skin with a simultaneous decrease in peripheral blood ternary cells. We made a diagnosis of EBV-associated HAAA. The treatment strategy for this patient included eltrombopag, an immunosuppressive regimen of rabbit anti-human thymocyte immunoglobulin, cyclosporine, and supportive care. The patient was discharged in normal physical condition after five months. A hemogram performed on follow-up revealed that he had achieved a complete response. CONCLUSION Eltrombopag plus anti-thymocyte globubin and cyclosporine may be a therapeutic option for EBV-associated HAAA.Larger studies are warranted to confirm.  相似文献   
2.
《Pancreatology》2022,22(1):74-82
ObjectivePost-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is the most common complication following ERCP and the mechanism is not fully understood. This study evaluated the changes in the inflammatory response, cellular apoptosis, and tight junction integrity in a rat model of pancreatitis to explore the underlying mechanism.MethodsPEP was induced in rats by retrograde biliopancreatic ductal infusion of contrast agents or saline. Pancreatic tissues were harvested and evaluated by histopathologic, immunohistochemical, immunofluorescence, and Western blot analyses. In addition, amylase and proinflammatory cytokines in plasma were quantified by ELISA assay.ResultsPEP rats developed more severe acute pancreatitis than the sham group after injection of the contrast agent or isotonic saline. PEP rats exhibited increased tissue damage, plasma amylase, proinflammatory cytokines, necrosis, inflammatory infiltrates, apoptosis, and tight junction disruption. At the molecular level, contrast agent and isotonic saline-injected PEP rats demonstrated elevated NF-κB p65 and STAT3 pathways activation, altered expression and activation of apoptosis-related proteins, and suppressed expression of tight junction molecules. However, the contrast agent concentration had no effect on these changes.ConclusionsIn models of acute pancreatitis induced using contrast agent and hydrostatic pressure, the contrast agent and high hydrostatic pressure easily induced the inflammatory response, apoptosis, and tight junction disruption. It is noteworthy that no significant difference in damaged pancreatic acinar cells was observed with different concentrations of the contrast agent.  相似文献   
3.
Myocardial perfusion imaging (MPI) is valuable for the diagnosis, prognosis, and management of coronary artery disease (CAD). The most commonly used pharmacologic stress agents at present are vasodilators and adrenergic agents. However, these agents have contraindications and may cause adverse effects in some patients. Thus, other stress agents feasible for more patients are required. Higenamine (HG) is a β-adrenergic receptor agonist currently approved for clinical trials as a stress agent for myocardial infarction. It also has a promising value in MPI for the detection of CAD in preclinical and clinical studies. This review summarizes the application of HG on MPI, including its mechanism of action, stress protocol, efficacy, and safety.  相似文献   
4.
目的 探究与分析造影剂碘普罗胺在妇科盆腔CT检查中的效果及其安全性。方法 运用回顾性研究方法,选取我院2018年2月—2021年1月收治的78例接受妇科盆腔CT增强检查者作为研究对象,观测全部患者的影像质量、全身及局部耐受性和相关不良反应。结果 在78例检查中,影像质量优良率为97.44%,患者耐受度为97.44%。患者出现恶心呕吐、头晕头痛、局部痛感、面部潮红的轻度不良反应占8.98%;有2例患者分别出现剧烈呕吐和胸闷气促,并伴有全身性皮疹的中度不良反应,给予相应处置后,患者均恢复正常。结论 非离子型造影剂碘普罗胺在妇科盆腔CT增强检查中能获得良好的影像质量,碘普罗胺的不良反应发生率低于离子型碘造影剂,但高于其他非离子型造影剂。  相似文献   
5.
BR55是以血管内皮生长因子受体2为靶点的靶向超声造影剂,可用于检测肿瘤新生血管形成提高诊断准确率。国外已有学者应用BR55进行人体超声分子成像,并显示出良好的安全性和耐受性。本文从BR55组成及特性、动物实验及临床应用等方面对BR55在评估肿瘤新生血管的研究进展进行综述。  相似文献   
6.
In liver transplant patients, solid tumors and post-transplant lymphoproliferative disorders have emerged as significant long-term mortality causes. In addition, it is assumed that de novo malignancy after liver transplantation (LT) is the second-leading cause of death after cardiovascular complications. Well-established risk factors for post-transplant lymphoproliferative disorders and solid tumors are calcineurin inhibitors, tacrolimus, and cyclosporine, the cornerstones of all immunosuppressive therapies used after LT. The loss of immunocompetence facilitated by the host immune system due to prolonged immunosuppressive therapy leads to cancer development, including LT patients. Furthermore, various mechanisms such as bacterial dysbiosis, activation through microbe-associated molecular patterns, leaky gut, and bacterial metabolites can drive cancer-promoting liver inflammation, fibrosis, and genotoxicity. Therefore, changes in human microbiota composition may contribute further to de novo carcinogenesis associated with the severe immunosuppression after LT.  相似文献   
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8.
基于LF-NMR/MRI的维C银翘片制粒中润湿剂评价方法研究   总被引:1,自引:0,他引:1  
目的应用低场核磁共振时域技术(low field nuclear magnetic resonance time domain technique,LF-NMR)、低场核磁成像技术(low field nuclear magnetic resonance imaging,LF-MRI)对高剪切制粒中润湿剂(乙醇)进行定性、定量分析。方法以维C银翘片高剪切湿法制粒为研究对象,采用LF-NMR建立润湿剂用量测定方法,结合横向弛豫时间(T2)和LFMRI测得的二位影像图对润湿剂分布与变化进行定性分析,探讨峰面积(A2)与颗粒得率的关系。结果润湿剂用量与A2呈现良好的相关性(R2=0.9575)。随着润湿剂用量增加,T2向右移动,A2逐渐增加,质子在增加;LF-MRI表明随着润湿剂用量增加,影像图逐渐清晰,即非结合态质子(束缚态质子及自由态质子)在颗粒中逐渐增加。当润湿剂用量增加至20%~25%时,结合态质子含量不再增加,此时颗粒得率最高。结论LF-NMR和LF-MRI能快速、准确检测制粒中润湿剂用量变化和分布状态,为阐明润湿剂对颗粒性质的影响和成型机制提供评价方法。  相似文献   
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10.
目的: 评价铁剂在慢性肾脏病(chronic kidney disease,CKD)患者使用中的合理性,为CKD5/5D期患者安全使用提供数据。方法: 回顾性分析了苏州大学附属第一医院(下称"我院")2020年出院的CKD患者的真实世界数据,制定铁剂使用规范,对使用铁剂的患者进行合理性评价,特别对CKD5/5D期患者使用铁剂的安全性进行了评估。结果: 共纳入254例患者,铁剂使用合理率为67.3%,潜在药物相互作用(drug-drug interactions,DDI)发生率72%,铁剂总ADR发生率为10.2%,CKD1~4期和CKD5/5D期ADR发生率分别为11.8%和10.0%(P>0.05)。存在潜在DDI的ADR发生率和无潜在DDI的ADR发生率分别为12%和5.6%(P>0.05)。结论: 我院CKD患者铁剂使用较为合理,CKD5/5D期患者使用铁剂安全性较高,DDI方面需要做好用药交代。  相似文献   
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