广泛性焦虑障碍住院患者与健康对照者的认知功能比较研究

背景 广泛性焦虑障碍（GAD）是常见的慢性精神疾病，常伴有不同程度的认知功能损害，严重影响患者的生活质量及社会功能。 目的 比较GAD住院患者与健康对照者认知功能的差异。 方法 选取2018年8月至2020年1月在南方医科大学南方医院住院治疗的GAD患者为GAD组（n=30），同期通过广告在南方医科大学南方医院住院患者陪护人员中招募年龄、性别相匹配的健康志愿者为健康对照组（n=30）。使用汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）和Beck自杀意念量表中文版（BSI-CV）进行心理测评，采用精神运动警觉性任务（PVT）、Go/No-go联想任务、N-back任务分别评估认知功能的注意、抑制及工作记忆功能。比较两组一般情况、量表测评总分及认知功能差异，进一步采用多因素Logistic回归分析探究GAD住院患者和健康对照者的认知功能差异。 结果 GAD组HAMA、HAMD总分和最严重情况时BSI-CV总分及最严重情况时存在自杀意念者所占比例高于健康对照组（P<0.05）。N-back任务：GAD组1-back击中目标率（NBACK1a）、2-back击中目标率（NBACK2a）低于健康对照组，1-back击中目标的平均反应时（NBACK1b）长于健康对照组（P<0.05）。多因素Logistic回归分析结果显示，NBACK1a〔OR=0.946，95%CI（0.898，0.997），P=0.038〕、NBACK1b〔OR=1.007，95%CI（1.000，1.014），P=0.042〕是GAD的影响因素。 结论 与健康对照者相比，GAD住院患者的工作记忆较差，需要临床关注。     

Evaluating a Food Pantry–Based Intervention to Improve Food Security,Dietary Intake,and Quality in Midwestern Food Pantries

BackgroundVoices for Food was a longitudinal community, food pantry–based intervention informed by the social ecological model, and designed to improve food security, dietary intake, and quality among clients, which was carried out in 24 rural food pantries across 6 Midwestern states.ObjectiveOur objective was to evaluate changes in adult food security, dietary intake, and quality from baseline (2014) to follow-up (2016), and to assess the role of adult food security on dietary outcomes.DesignA multistate, longitudinal, quasi-experimental intervention with matched treatment and comparison design was used to evaluate treatment vs comparison group changes over time and changes in both groups over time.Participants/settingAdult food pantry clients (n = 617) completed a demographic food security survey, and up to three 24-hour dietary recalls at baseline (n = 590) and follow-up (n = 160).InterventionCommunity coaching served as the experimental component, which only “treatment” communities received, and a food council guide and food pantry toolkit were provided to both “treatment” and matched “comparison” communities.Main outcome measuresChange in adult food security status, mean usual intakes of nutrients and food groups, and Healthy Eating Index-2010 scores were the main outcome measures.Statistical analyses performedLinear mixed models estimated changes in outcomes by intervention group and by adult food security status over time.ResultsImprovements in adult food security score (–0.7 ± 0.3; P = .01), Healthy Eating Index-2010 total score (4.2 ± 1.1; P < .0001), and empty calories component score (3.4 ± 0.5; P <.0001) from baseline to follow-up were observed in treatment and comparison groups, but no statistically significant changes were found for adult food security status, dietary quality, and usual intakes of nutrients and food groups between the 2 groups over time. The intervention effect on dietary quality and usual intake changes over time by adult food security status were also not observed.ConclusionsFood pantry clients in treatment and comparison groups had higher food security and dietary quality at the follow-up evaluation of the Voices for Food intervention trial compared with baseline, despite the lack of difference among the groups as a result of the experimental coaching component.     

日本居家安宁疗护服务体系构建经验及其对我国的启示

21世纪的日本"少子高龄化"特征明显，发展居家安宁疗护、构建完备的居家安宁疗护服务体系，是日本卫生服务提供体制改革的重要方向。本文介绍了日本居家安宁疗护的含义与理念，以及关于居家安宁疗护服务提供机构、提供人员、提供内容及费用保障的法律规定，提示我国在条件成熟时应尽快健全安宁疗护相关立法，在卫生服务提供体系框架下实现居家安宁疗护的稳定发展，建立并强化安宁疗护过程中的协作机制，并为居家安宁疗护提供必要的经费保障，通过完善的制度设计保障老年人"居家善终"的权益。     

Center of pressure position in the touches of the star excursion balance test in healthy individuals

BackgroundThe Star Excursion Balance Test (SEBT) is a clinical test that aims to assess postural control. Its interpretation is related to the understanding of the motor specificities required. Adjustments must be made to the center of pressure (COP) to maintain balance during testing movements. Comprehend the specifics of these adjustments for each direction can allow the development of more suitable exercises for balance training. The aim was to compare the positions of the COP on the different directions of the SEBT and correlate the reachs obtained in the SEBT with the distances from the COP to the borders of the base of support (BOS).MethodsSixteen healthy subjects participated in the study. Measurements were made by performing the SEBT over the force platform. The Kruskal-Wallis test followed by Bonferroni's post hoc test was used to compare directions. The Pearson correlation test was used to check the correlation of parametric variables and Spearman correlation test for the nonparametric ones.ResultsThe position of the COP at the touch differs from the anterior direction to the other directions of the SEBT and the performance in this direction is correlated with the proximity of the COP to the anterior limit of the support base. The performances in the other directions did not correlate with the COP position.ConclusionThe requirements of the compensation mechanisms for postural control are different between the directions of the SEBT.     

Index-Based Dietary Patterns and the Risk of Prostate Cancer among Iranian Men

Background and objective: The second most common cancer in men after lung cancer is prostate cancer (PC).Previous studies assessed the association between food items or food groups and the risk of PC, but diet quality indicesare unique approaches to study any relations between diet and disease. Our objective was to investigate the effect ofhealthy eating index (HEI-2010) and Mediterranean-Style Dietary Pattern Score (MSDPS) on PC risk. Methods: Inthis case-control study, we recruited 97 patients with MS and 205 control subjects . Dietary intake was evaluted usinga valid and reliable food frequency questionnaire. The HEI and MSDPS were calculated. Logistic regression was usedto evaluate the relationship between HEI and MSDP scores and PC risk after adjusting the confounders. Results: Incomparison to controls, cases had lower score on HEI (61 vs. 70.07; P< 0.001), and higher score on MSDP (26.20 vs.24.49; P= 0.44). After comparing the highest and the lowest tertile of HEI, we observed a significant decreasing trendin the risk of PC (p for trend<0.001). Conclusion: Our findings suggested that a high quality diet, according to HEI,may decrease the risk of PC.     

The influence of environmental and health indicators on premature mortality: An empirical analysis of the City of Toronto's 140 neighborhoods

The objective of this paper was to assess the link between premature mortality and a combination of neighbourhood contextual (environmental and health) and compositional (socioeconomic and demographic) characteristics. We statistically and spatially examined six environmental variables (ultrafine particles, carcinogenic and non-carcinogenic pollutants, pollution released to air, tree cover, and walkability index), six health service indicators (number health providers, breast, colorectal and cervical cancer screening uptake rates, student nutrition program uptake rates, and healthy food index), and eight socioeconomic indicators (total income, Gini coefficient, two age categories – below and above 40 years, proportion of females to males, visible minorities, Indigenous peoples, education, less than grade 9) among 140 neighbourhoods of the City of Toronto in Ontario (Canada). We applied principal component analysis to identify patterns and to reduce the number of explanatory variables into combined component axes that represent unique variation in these confounded and overlapping factors. We then applied regression analysis to model the relationship between the indices of enviro-health and socioeconomics and their potential relationship with premature mortality. Residual spatial analysis was used to investigate any remaining spatial structure (such as neighbourhoods with higher residual premature mortality rates). Neighbourhood Equity Index was correlated with our enviro-health and socioeconomic indices. Premature mortality within neighbourhoods was predicted by poor cancer screenings, pollution, lack of tree canopy, increased uptake of student nutrition programs and high walkability index. A negative association between premature mortality and pollution was associated low walkability index and presence of visible minorities within neighbourhoods. There was some unexplained residual spatial variation in our model of premature mortality - especially along the shores of Lake Ontario and in neighbourhoods with major highways or road corridors: premature mortality in Toronto neighbourhoods was higher than expected along highway-corridor neighbourhoods and shorelines. Our analysis revealed a significant relationship between neighbourhood contextual features – both environmental and health – and premature mortality, suggesting that these contextual components of neighbourhoods can predict rates of urban premature mortality in Toronto.     

Antioxidants Properties,Physicochemical, and Sensory Quality Attributes of a New Soy-Based Beverage with Lemongrass and Lime Juice

This work aimed at developing a new soy-based beverage and studying the influence of formulation ingredients on its antioxidants, physicochemical, and sensory properties. For this purpose, mixed beverages with lemongrass, lime juice, and soymilk were formulated. Soy-based beverages showed differences in pH, ratio, and color as compared to mixed beverages without soy. Soymilk increased the phenolics content and the ABTS antioxidant capacity, while lemongrass aqueous extract increased the DPPH antioxidant capacity of soy-based beverages. The new soy-based beverage had good acceptance for all attributes and can be considered a viable alternative source of nutrients and bioactive compounds to consumers.     

社区老年人骨质疏松症健康行为和自我效能的调查研究

目的 了解北京市社区老年人预防骨质疏松症健康行为和自我效能的情况，并分析影响自我效能的相关因素。方法 采用方便抽样法选取2016 年1～3 月北京市朝阳区两个社区的109 名60 岁以上老年人为调查对象，应用含预防骨质疏松症健康行为信息的一般情况调查表和骨质疏松症自我效能问卷对其进行调查。结果 （1）预防骨质疏松症相关性健康行为方面，49.54%的老年人补充钙剂，53.21%的老年人运动量合理，28.44%的老年人服用维生素；（2）社区老年人骨质疏松症总自我效能得分为（69.10±19.36）分，不同文化程度、职业的自我效能得分比较，差异有统计学意义（P＜0.05）。结论 社区老年人运动和摄钙行为不足，自我效能有待提高，应加强骨质疏松症的健康教育普及及行为方式干预，促使老年人养成良好的生活习惯，从而更好地预防骨质疏松；同时应重点关注文化程度较低的老年人，给予其更多的指导和帮助，并针对不同职业的老年人分别开展健康教育。     

The curvilinear relationship of early-life adversity and successful aging: the mediating role of mental health

Objectives: The steeling effect suggests that early-life adversity can have a beneficial impact later in life. However, little is known about its underlying mechanisms and long-term outcomes . The study aimed to examine the role of early-life adversity (ELA) on successful aging, and whether this relationship can be explained by mental and physical health.

Method: Socio-demographics, early-life adversity (ELA), individual quality of life (iQoL), and mental and physical health of 270 individuals (M_age = 66.82 years, 71.5% female) were assessed. Polynomial regressions and mediation analyses were conducted.

Results: Significant inverse U-shaped associations were found between ELA and iQoL (β = ?.59, p = .005) and between ELA and mental health (β = ?.64, p = .002), but not between ELA and physical health. Furthermore, mental health significantly mediated the relationship between ELA and iQoL (b = ?.84, BCa CI [?1.66, ?.27]).

Conclusion: Highest level of individual quality of life (i.e. successful aging) was related to a moderate amount of ELA. Additionally, mental health significantly mediated this relationship. These findings suggest that some amount of ELA could be beneficial for successful aging. Resource-focused interventions are needed to improve health and promote successful aging for an underdetected, at-risk subgroup with low early-life adversity.