Do buffered local anesthetics provide more successful anesthesia than nonbuffered solutions in patients with pulpally involved teeth requiring dental therapy?: A systematic review

Background

The authors conducted a systematic review that addresses the following population, intervention, comparison, outcome question: “In adults requiring dental therapy with pulpally involved teeth, what is the comparative efficacy of buffered local anesthetics (LAs) compared with that of nonbuffered LAs in achieving anesthetic success?”

老年人消化性溃疡的特点分析

报道146例老年与139例中青年消化性溃疡患者,老年人消化性溃疡具有症状不典型,腹痛少,出血率高,溃疡面积大,伴随疾病多的特点。此外,老年组幽门螺杆菌(HP)检出率为77.8％,高于中青年组的56％(P<0.05),因此对老年消化性溃疡的治疗除加强胃粘膜保护及制酸剂治疗外,抗HP治疗及加强对伴随疾病的治疗也十分必要。     

Experimental hypersensitivity pneumonitis: role of MCP-1

Inhalation of Saccharopolyspora rectivirgula causes "farmer's lung" disease, a classic example of hypersensitivity pneumonitis (HP). Monocyte chemoattractant protein-1 (MCP-1) is increased in the bronchoalveolar lavage fluid of mice challenged with S rectivirgula, and S rectivirgula induces MCP-1 secretion by alveolar macrophages. We tested the hypothesis that MCP-1 and its receptor CC chemokine receptor-2 (CCR2) are essential to the development of experimental HP by treating mice with MCP-1 antibody and using CCR2(-/-) mice. Administration of anti-MCP-1 did not change the response to intratracheally administered S rectivirgula. CCR2(-/-) animals responded in a fashion similar to that of wild-type animals to intratracheally administered.S rectivirgula. To determine the influence of the MCP-1-CCR2 interaction in vitro, we transferred S rectivirgula-cultured spleen cells from S rectivirgula-sensitized mice, to na?ve recipients. Later, challenge of the recipients with intratracheal S rectivirgula and examination of both lung histology and bronchoalveolar lavage fluid characteristics were used to determine whether adoptive transfer had occurred. We found that cultured cells from CCR2(-/-) animals were fully capable of adoptive transfer. We conclude that interaction of MCP-1 with CCR2 is not necessary for the development of pulmonary inflammation in response to intratracheally administered S rectivirgula or cells able to adoptively transfer experimental HP.     

中医辨证论治Hp相关性慢性胃炎30例

目的:观察中医辨证论治联合西医三联根除方案治疗Hp相关性慢性胃炎的临床疗效。方法:将60例Hp相关性慢性胃炎患者随机分为对照组和治疗组各30例,对照组单纯予三联根除方案,治疗组给予中药联合西医三联根除方案,中药疗程8周,西药疗程7 d。观察两组Hp根除率和主要症状改善情况。结果:治疗组Hp根除率为83.3%,对照组Hp根除率为66.7%,两组Hp根除率比较,差异有统计学意义(P0.05);治疗组主要症状积分改善程度优于对照组(P0.05)。结论:中药辨证论治联合西医三联根除Hp疗法可以提高Hp根除率,改善患者主要不适症状。     

2369例高校职工幽门螺杆菌感染检测结果分析

目的 观察高校教职工人群胃幽门螺杆菌(HP)感染情况,加强对其感染的防控工作。方法 空腹采集教职工体检人群静脉血,检测胃幽门螺杆菌抗体滴度,观察其感染情况。结果 人群HP总阳性率为43.31%。其中:男性阳性率为45.82%,女性阳性率为40.53%,差异有统计学意义(P<0.05)。按年龄段分组比较其感染情况,各年龄组阳性率男性普遍高于女性,但只有41～50岁组男性与女性比较差异有统计学意义(P<0.05)。41～50岁年龄组和51～60岁年龄组阳性率高于其他年龄组,差异有统计学意义(P<0.05)。结论 胃幽门螺杆菌感染率较高,且男性感染率高于女性。应加强对该疾病的预防保健工作,提高人群防病治病的健康意识。     

Evaluation of the protective efficacy of four newly identified surface proteins of Erysipelothrix rhusiopathiae

Erysipelothrix rhusiopathiae is the causative agent of animal erysipelas and human erysipeloid. Bacterial surface proteins are promising vaccine candidates. We recently identified 3 E. rhusiopathiae surface proteins (GAPDH, HP0728, and HP1472) and characterized their roles as virulence factors. However, their efficacy as protective antigens is still unknown. The N-terminal region of a previously identified surface protein, CbpB (CbpB-N), is speculated to be a protective antigen, but this needs to be verified. The aim of this study was to evaluate the protective efficacy of GAPDH, HP0728, HP1472, and CbpB-N. Immunization with recombinant GAPDH provided complete protection in a mouse model, recombinant CbpB-N provided partial protection, while recombinant HP0728 and HP1472 provided no protection. Recombinant GAPDH also provided good protection in a pig model. GAPDH antiserum exhibited significant blood bactericidal activity against E. rhusiopathiae. In conclusion, GAPDH and CbpB-N were found to be protective antigens of E. rhusiopathiae, and GAPDH is a promising vaccine candidate.     

The effect of uranium migration on radionuclide distributions for soil samples at the El-Gor area,Sinai, Egypt

The concentrations and distributions of the activity of natural radionuclides in soil samples were investigated in fifteen soil samples at El-Gor area representing two profiles (A and B) using a HP–Ge detector and alpha counting by SSNTD (CR-39), respectively. The average concentrations of the radionuclides ²³⁸U, ²²⁶Ra, ²³⁵U, ²³²Th and ⁴⁰K are 203.4, 177.23, 9.77, 43.33 and 386.22 Bq kg⁻¹ (dry weight), respectively, and profile A and ²³⁸U, ²²⁶Ra, ²³⁵U, ²³²Th and ⁴⁰K have average concentrations of 232.58, 246, 11.7, 31.7, and 277.07 Bq kg⁻¹ for profile B, respectively. The eTh and eU were estimated to detect the migration process of uranium into or out of an area or uranium to or from the studied profiles. The results indicate a migration of uranium by 29% for profile A and 65.37% for profile B. The activity ratio (²³⁸U/²²⁶Ra) was found to be 0.9 in profile A and 1.15 in profile B. These ratios coincide with the uranium migration processes. The responsible mass corresponding to the measured ²²⁶Ra activity was also calculated. The radon activity concentrations for the two profiles are nearly 300 Bq m⁻³. The emanation coefficient (η) was calculated from the ratio of the expected radon activity to the measured radon for the studied soil samples. The value of η was found to depend only on the radium activity regardless to soil formation.     

婴儿组织胞浆菌病1例并文献复习

目的提高对婴儿组织胞浆菌病(histoplasmosis,HP)的认识。方法报告1例婴儿组织胞浆菌病,并结合文献对该病病原学、流行病学、临床表现、诊断和治疗等方面进行分析。结果婴儿HP以不规则发热、咳嗽、腹泻、肝脾肿大为主要临床表现,骨髓穿刺检查找到组织胞浆菌确诊。结论 HP是由荚膜组织胞浆菌感染所致的一种以侵犯网状内皮系统或肺部为主的深部真菌病。婴儿HP临床表现多样,以播散型为主,病情进展迅速,在短期内即可造成多器官功能衰竭而导致救治失败。确诊有赖病原学的检查。     

蜂蜇伤致多器官功能障碍综合征一例并文献复习

目的 总结蜂蜇伤致多器官功能障碍综合征（MODS）的治疗经验,提高蜂蜇伤的诊断和治疗水平.方法 回顾性分析蜂蜇伤致MODS患者1 例,总结救治经验并复习相关文献,探讨蜂蜇伤的发病机制、临床表现、治疗方案、疗效及死因等.结果 蜂蜇伤以蜂毒致病,可致过敏性休克、肾衰竭或多器官功能衰竭等严重后果,病死率与衰竭器官数目有关.其治疗包括局部处理、全身用药、血液净化等综合性治疗.结论 在基础治疗的早期连续性肾脏替代治疗联合血液灌流（CRRT ＋ HP）是蜂蜇伤致MODS 有效的治疗手段.