首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   764篇
  免费   5篇
  国内免费   65篇
儿科学   74篇
妇产科学   4篇
基础医学   37篇
临床医学   72篇
内科学   478篇
皮肤病学   3篇
神经病学   2篇
特种医学   5篇
外科学   62篇
综合类   25篇
预防医学   38篇
药学   24篇
  1篇
中国医学   3篇
肿瘤学   6篇
  2023年   14篇
  2022年   34篇
  2021年   53篇
  2020年   26篇
  2019年   120篇
  2018年   56篇
  2017年   29篇
  2016年   8篇
  2015年   20篇
  2014年   31篇
  2013年   29篇
  2012年   17篇
  2011年   20篇
  2010年   16篇
  2009年   13篇
  2008年   24篇
  2007年   9篇
  2006年   8篇
  2005年   4篇
  2004年   2篇
  2003年   1篇
  2001年   2篇
  2000年   1篇
  1997年   4篇
  1996年   1篇
  1990年   1篇
  1988年   1篇
  1985年   33篇
  1984年   35篇
  1983年   13篇
  1982年   24篇
  1981年   27篇
  1980年   24篇
  1979年   28篇
  1978年   26篇
  1977年   22篇
  1976年   16篇
  1975年   19篇
  1974年   10篇
  1973年   13篇
排序方式: 共有834条查询结果,搜索用时 15 毫秒
1.
IntroductionEndoscopic surveillance guidelines for patients with repaired esophageal atresia (EA) rely primarily on expert opinion. Prior to embarking on a prospective EA surveillance registry, we sought to understand EA surveillance practices within the Eastern Pediatric Surgery Network (EPSN).MethodsAn anonymous, 23-question Qualtrics survey was emailed to 181 physicians (surgeons and gastroenterologists) at 19 member institutions. Likert scale questions gauged agreement with international EA surveillance guideline-derived statements. Multiple-choice questions assessed individual and institutional practices.ResultsThe response rate was 77%. Most respondents (80%) strongly agree or agree that EA surveillance endoscopy should follow a set schedule, while only 36% claimed to perform routine upper GI endoscopy regardless of symptoms. Many institutions (77%) have an aerodigestive clinic, even if some lack a multi-disciplinary EA team. Most physicians (72%) expressed strong interest in helping develop evidence-based guidelines.ConclusionsOur survey reveals physician agreement with current guidelines but weak adherence. Surveillance methods vary greatly, underscoring the lack of evidence-based data to guide EA care. Aerodigestive clinics may help implement surveillance schedules. Respondents support evidence-based protocols, which bodes well for care standardization. Results will inform the first multi-institutional EA databases in the United States (US), which will be essential for evidence-based care.Level of EvidenceThis is a prognosis study with level 4 evidence.  相似文献   
2.
Photodynamic therapy (PDT) is the local destruction of tissue by the interaction of light with a previously administered photosensitizer producing a photochemical effect. This technique has been demonstrated to permit the eradication of small tumours in experimental and clinical practice, with clear biological advantages. This paper reviews PDT experience in gastroenterology, together with concepts currently under experimental investigation.  相似文献   
3.
中国科技期刊如何进入国际信息检索系统   总被引:4,自引:0,他引:4  
以被多种国际著名信息检索系统收录的World Journal of Gastroenterology(WJG)杂志的发展历程为样例。探讨如何提高中国出版的科技期刊被国际信息系统收录的命中率,提高期刊的国际地位和知名度,更好地促进与国际的学术交流。  相似文献   
4.
目的 比较临床专业学位研究生培养与住院医师规范化培训相结合的模式(简称“并轨”模式)与“传统”模式培养对临床专业学位研究生在消化科轮转中的意义。方法 选取2012年7月至2016年7月在青岛市市立医院消化内科轮转的临床专业学位研究生为研究对象,分别应用“并轨”模式(30人)或“传统”模式(20人)培养,比较研究生的临床知识、技能以及各项核心能力。采用SPSS 13.0进行t检验和卡方检验。结果 “并轨”模式较“传统”模式培养的研究生临床考核各项成绩总分明显提高,差异具有统计学意义[(92.60±2.52)vs.(83.80±3.14),t=10.93,P<0.01];两种模式培养的研究生在职业素养、医患沟通能力方面差异无统计学意义;“并轨”模式培养后的研究生在临床专业理论知识及临床思维能力、诊治技能、心理素质方面均明显优于“传统”模式培养的研究生(χ2=27.00, χ2=10.23, χ2=12.21,P均<0.01),差异具有统计学意义;但在临床科研能力方面,“传统”模式较“并轨”模式略有提高,差异无统计学意义(χ2=1.39,P=0.24)。结论 “并轨”模式优于“传统”模式,“并轨”模式较“传统”模式更有利于培养其临床实践等综合能力,值得进一步推广。  相似文献   
5.
Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH) pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH remains obscure. This translational study aims to describe the patterns of intrahepatic neutrophil infiltration and its involvement in SAH pathogenesis. Immunohistochemistry analyses of explanted livers identified two SAH phenotypes despite a similar clinical presentation, one with high intrahepatic neutrophils (Neuhi), but low levels of CD8+ T cells, and vice versa. RNA-Seq analyses demonstrated that neutrophil cytosolic factor 1 (NCF1), a key factor in controlling neutrophilic ROS production, was upregulated and correlated with hepatic inflammation and disease progression. To study specifically the mechanisms related to Neuhi in AH patients and liver injury, we used the mouse model of chronic-plus-binge ethanol feeding and found that myeloid-specific deletion of the Ncf1 gene abolished ethanol-induced hepatic inflammation and steatosis. RNA-Seq analysis and the data from experimental models revealed that neutrophilic NCF1-dependent ROS promoted alcoholic hepatitis (AH) by inhibiting AMP-activated protein kinase (a key regulator of lipid metabolism) and microRNA-223 (a key antiinflammatory and antifibrotic microRNA). In conclusion, two distinct histopathological phenotypes based on liver immune phenotyping are observed in SAH patients, suggesting a separate mechanism driving liver injury and/or failure in these patients.  相似文献   
6.
7.
上海交通大学医学院附属仁济医院消化学科在“211”二期项目建设成果的基础上,经过5年三期建设的努力,除在原有优势项目如对消化系肿瘤发生与诊治和慢性肝病诊治的研究取得了诸多成效外,还开辟了小肠疾病诊治研究的新领域.建设期间,系统研究了消化系肿瘤(胃癌和大肠癌)发生的分子机制、早期诊断和综合预防,特别是表观遗传修饰(DNA甲基化、组蛋白修饰、micro RNA等)与信号通路在消化系肿瘤发生和发展中的作用;建立胶囊内镜和双气囊内镜在小肠疾病诊断中的关键技术,从而提高小肠疾病的诊断率,探索并开拓了小肠内镜诊断应用的新途径,使小肠内镜在我国得到普及和推广,并对血管发育不良所致不明原因消化道出血进行临床创新性治疗及其机制探索;建立了慢性乙型病毒性肝炎肝纤维化非创诊断模型,同时系统阐述并证实了核苷类抗病毒药及氧化苦参碱等在抑制纤维化及减缓疾病进展中的作用和机制.以上研究成果获得两项国家科技进步二等奖,并进入“国家临床重点专科(消化内科)”和“国家临床重点专科(卫生部重点实验室)”建设行列,学科总体水平得以显著提高.  相似文献   
8.
9.
The growing interest in the possibility of applying stem-cell therapies to gastroenterological diseases is outlined. Some promising results have been reported, but more research is needed in view of the uncertainties and knowledge gaps that still exist. The ethical issues raised by this kind of research are then indicated and classified. Three problematic kinds of situation are outlined: experimental treatments, stem-cell tourism and biobanking. A four-question approach – which is not to be confused with the well-known four-principle approach introduced by Beauchamp and Childress – is described and applied to these three challenging situations. In conclusion, it is pointed out that the analysis of these situations illustrates the interplay between definitions, empirical research and ethics. They are interrelated and need to be integrated.  相似文献   
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号