玻切二期术后低视力人群的护理策略

目的对玻切二期术后低视力人群采取特殊的护理策略,来平复病人的负面情绪,提高治疗满意度。方法对2019年11月6日至2020年11月6日在我院接受玻璃体切割二次手术的96名低视力患者进行特殊护理干预,然后进行回顾性分析。结果在结合实际病情分析采取的特殊护理策略干预下,病人术后情绪稳定,未出现不良投诉事件,满意度较高。结论对玻切二期术后低视力人群采取特殊的护理干预策略十分必要。     

Bioactive glasses for in situ tissue regeneration

Historically the function of biomaterials has been to replace diseased or damaged tissues. Recent findings show that controlled release of the ionic dissolution products of bioactive glasses results in regeneration of tissues. The mechanism for in situ tissue regeneration involves upregulation of seven families of genes that control the osteoblast cell cycle, mitosis and differentiation. In the presence of critical concentrations of Si and Ca ions, within 48 h osteoblasts that are capable of differentiating into a mature osteocyte phenotype begin to proliferate and regenerate new bone. Osteoblasts that are not in the correct phase of the cell cycle and unable to proceed towards differentiation are switched into apoptosis by the ionic dissolution products. A controlled release of soluble Ca and Si from bioactive glass - resorbable polymer composites leads to vascularised soft tissue regeneration. Gene activation by controlled ion release provides the conceptual basis for molecular design of a third generation of biomaterials optimised for in situ tissue regeneration.     

A Biomimetic Material with a High Bio-responsibility for Bone Reconstruction and Tissue Engineering

A biomimetic composite was prepared using type-I collagen as the matrix, and particles of sol–gel-derived bioactive glass (58S), hyaluronic acid and phosphatidylserine as additives. The material has an interconnected 3-D porous structure with a porosity > 85%. When incubated in simulated body fluid (SBF), the composite induced the formation of microcrystals of bone-like hydroxyapatite (HA), suggesting good bioactive properties. During the in vitro cell-culture experiment, MC3T3-E1 cells adhered to, migrated and spread on the surface of the porous composite. The material was employed to repair a 10-mm defect in a rabbit's radius. The composite was gradually degraded within 8 weeks and replaced by new bone. After 12 weeks, the bone marrow cavity was restored and the Haversian canal was noted from the histological observation. The biomimetic composite is a potential scaffold material for bone reconstruction and bone tissue engineering.     

Composite Films of Gelatin and Hydroxyapatite/Bioactive Glass for Tissue-Engineering Applications

Cross-linked gelatin/hydroxyapatite/bioactive glass (G/HA/CEL2) films with different compositions (100:0:0 (G1); 30:70:0 (G2); 30:0:70 (G3); 30:35:35 (G4) (%, w/w/w)) were prepared as scaffold materials for tissue-engineering applications, particularly in the field of bone repair. A bioactive glass with 45% SiO₂, 3% P₂O₅, 26% CaO, 7% MgO, 15% Na₂O and 4% K₂O molar composition was selected (CEL2). Genipin was used as a cross-linker for the gelatin component. Samples were characterized in terms of their bioactivity, thermal properties, mechanical behaviour and cell compatibility. After only 3 days of incubation in simulated body fluid (SBF) at 37°C, calcium phosphate crystals precipitated on G3 and G4 surfaces, due to the high CEL2 bioactivity. Cross-linking increased the thermal stability of the gelatine component as indicated by thermal analysis (denaturation temperature was 92.3°C and 97.6°C for not cross-linked and cross-linked gelatin, respectively). Furthermore, tensile modulus of samples increased with increasing the inorganic phase amount (from 4.72 ± 0.23 MPa for G1 to 6.46 ± 0.05 MPa for G4). The adhesion and proliferation of human primary osteoblasts on composite films was evaluated. Cell viability was high with respect to the control for all samples and the presence of hydroxyapatite exerted an important role in the ability of mineralization.     

The occurrence of antimicrobial substances in toilet,sink and shower drainpipes of clinical units: A neglected source of antibiotic residues

Antibiotics represent one of the most important drug groups used in the management of bacterial infections in humans and animals. Due to the increasing problem of antibiotic resistance, assurance of the antibacterial effectiveness of these substances has moved into the focus of public health. The reduction in antibiotic residues in wastewater and the environment may play a decisive role in the development of increasing rates of antibiotic resistance. The present study examines the wastewater of 31 patient rooms of various German clinics for possible residues of antibiotics, as well as the wastewater of five private households as a reference.To the best of our knowledge, this study shows for the first time that in hospitals with high antibiotic consumption rates, residues of these drugs can be regularly detected in toilets, sink siphons and shower drains at concentrations ranging from 0.02?μg·L^?1 to a maximum of 79?mg·L^?1. After complete flushing of the wastewater siphons, antibiotics are no longer detectable, but after temporal stagnation, the concentration of the active substances in the water phases of respective siphons increases again, suggesting that antibiotics persist through the washing process in biofilms. This study demonstrates that clinical wastewater systems offer further possibilities for the optimization of antibiotic resistance surveillance.