“Late” recovery of the right ear dichotic score following cerebrovascular accident: A case report

Late recovery of the right ear score on a digit dichotic listening test was observed in a 45-yr-old female patient. The right ear score was at chance levels of accuracy through the ninth month post-onset of a cerebrovascular accident and then improved dramatically to 67% correct by month 12. Possible bases for this pattern of performance are discussed     

结核分枝杆菌Rv1626的原核表达及其免疫功能研究

结核分枝杆菌;Rv1626;原核表达;免疫原性;结核病     

3,4-Bis(3′-hydroxyphenyl)hexane —A new mammary tumor-inhibiting compound

Summary Biochemical properties, such as the activities of eight carbohydrate-metabolism-linked enzymes and four acid hydrolases, and histological characteristics of growing and regressing DMBA-induced mammary tumors of the SD-rat after ovariectomy or treatment of the host with hexestrol, tamoxifen, and 3,4-bis(3-hydroxyphenyl_hexane were determined. Significant differences were found between growing and regressing tumors regardless of the treatment animals had been subjected to. Only few differences in biochemical parameters could be found within the group of tumors regressing due to the applied therapy. The histological signs of regressing tumors were very diverse, but no phenomenon typical of a specific treatment could be found. It cannot be decided whether the partial antiestrogen, 3,4-bis(3-hydroxyphenyl)hexane unfolds its antimmary tumor activity by means of its estrogenic or its antiestrogenic potency. The hypothesis that estrogens inhibit mammary tumor growth by directing neoplastic cell metabolism toward secretion is not supported by these findings.Dedicated to Professor Dr. N. Brock on his 70th birthdaySupported by the Deutsche Forschungsgemeinschaft and by the Verband der Chemischen Industrie, Fonds der Chemischen Industrie     

LC-MS法测定大鼠血浆中EXH-1626的浓度

目的:建立测定大鼠血浆中EXH-1626浓度的液相色谱-质谱(LC-MS)方法?方法:大鼠血浆样品中加入内标卡马西平,经蛋白沉淀剂(甲醇∶5%硫酸锌溶液 = 70∶30,V/V)沉淀血浆蛋白后取上清液5 μl进行LC-MS测定?色谱条件:色谱柱为汉邦ODS C18柱(5 μm,150 mm × 4.6 mm),流动相为乙腈∶10 mmol/L醋酸铵水溶液(用乙酸调pH至3)70∶30,流速为0.6 ml/min,柱温30℃;质谱条件:采用电喷雾离子化(ESI)方式,以选择性离子监测(SIM)方式检测,EXH-1626和内标选择检测离子的质荷比(m/z)分别为453.3([M+H]+)和274.3([M+H]+)?结果:大鼠血浆中EXH-1626在5~10 000 ng/ml内线性关系良好(r = 0.999 7),最低定量限(LOQ)为5 ng/ml,由低到高(10?100?1 000和10 000 ng/ml)4个浓度的日内和日间精密度RSD均< 10%,绝对回收率均> 70%,相对回收率90%~110%?结论:该方法快速?准确,灵敏度高,操作简便,适用于EXH-1626血药浓度测定及其非临床药代动力学研究?