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The phytochemical investigation of Digitalis trojana led to the isolation of two cardiac glycosides (1, 2), one pregnane glycoside (3), three furostanol type saponins (4–6), along with three cleroindicins (7–9), four phenylethanoid glycosides (10–13), two flavonoids (14, 15) and two phenolic acid derivatives (16, 17). The structure elucidation of the isolates was carried out by NMR experiments as well as ESI‐MS. The cytotoxic activity of compounds 1–13 against a small panel of cancer cell lines, namely MCF‐7, T98G, HT‐29, PC‐3, A375 and SH‐SY5Y, was investigated. Compounds 1–6 showed antiproliferative activity against human breast MCF‐7 and colon HT‐29 cancer cell lines with IC50 values ranging from 8.3 to 50 μM. In order to understand the mechanism involved in the cell death, the active compounds were tested as pro‐apoptotic agents using propidium iodide staining by flow cytometry method. No significant increase was observed in the apoptosis of the MCF‐7 and HT‐29 cancer cells. Moreover, the effects of the active compounds on cell proliferation were assessed on the same cancer cell lines by cell cycle analysis of DNA content using flow cytometry. No significative changes were observed in the cell cycle of MCF‐7, while significant changes in G2/M cell cycle phase of HT‐29 cells were observed after treatment with digitalin (1), cariensoside (3) and 22‐O‐methylparvispinoside B (6) at 10 μM. Copyright © 2013 John Wiley & Sons, Ltd.  相似文献   
3.
This report describes a digitalis-induced regular fascicular ventricular tachycardia characterized by marked QRS alternans a manifestation not usually associated with this arrhythmia. The striking alternation of QRS configuration suggested alternating ventricular activation from either a single focus with two exits in distal branches of the left anterior fascicle or 2 different foci localized in the Purkinje-myocardial network of the left anterior fascicle.  相似文献   
4.
Objectives Although development of new treatment modalities limited digoxin usage, digoxin intoxication is still an important issue which could be easily overlooked. In this report we analyzed a case series definitively diagnosed as digoxin intoxication in the modern era. Methods We analyzed 71 patients hospitalized with digoxin intoxication confirmed by history, complaints, clinical and electrocardiograph (ECG) findings, and serum digoxin levels > 2.0 ng/mL, during a five year period. The demographic and clinical data, indications for digoxin use, digoxin dosage, concurrent medications, laboratory data, hospital monitoring, and ECG findings were obtained from all patients. Results Thirty-eight of 71 patients (53.5%) had symptoms of heart failure during admission or later. Sixty-four percent of patients were older than 75 years. The percentage of females was 67%. Atrial fibrillation, hypertension and gastrointestinal complaints were more frequent in the females (64% in females, 30% in males, P = 0.007; 81% in female, 52% in males, P = 0.01; 50% in female, 17.3% in males, P = 0.008, respectively). The mortality rate during the hospital course was 7%. Conclusion This report demonstrated the reduced mortality rates in patients with digoxin intoxication over the study period. Gastrointestinal complaints are the most common symptoms in this population.  相似文献   
5.
目的:观察慢性充血性心力衰竭中心气(血)虚证和心阴不足证患者血清内源性洋地黄因子含量的变化,探讨其临床意义。方法:以放免法测定正常人与慢性充血性心动力衰竭患者中心气(血)虚组与心阴不足组内源性洋地黄因子的含量。结果:心气(血)虚患者内源性洋地黄因子含量比心阴不足型显著下降(P<0.01)。结论:内源性洋地黄因子分泌减少可能是导致中医心气(血)不足的主要原因之一,而心阴不足证患者内源性洋地黄因子含量比心气(血)虚证患者降低程度小,提示在中西医结合治疗中对前类患者使用洋地黄药物效果可能更好,而对后类患者应谨慎使用洋地黄类药物。  相似文献   
6.
目的 比较普罗帕酮与洋地黄转复慢性房颤的作用。方法 房颤发作时间大于3周的患者随机分为普罗帕酮组和洋地黄组,普罗帕酮组先静脉推注普罗帕酮2mg/kg,再以5mg/kg维持24小时,后改口服每天450mg治疗4周。洋地黄组先静脉推注毛花甙C 0.4mg,然后每6小时静脉推注0.2mg,24小时后改口服地高辛每日0.25mg。结果 普罗帕酮组17例(48.6%)转复为窦性心律,洋地黄组仅2例转复成功。普罗帕酮组转复成功者与未转复者相比,左房内径明显较小(P<0.001),房颤持续时间显著较短(P<0.001)。结论 普罗帕酮可有效地用于慢性房颤的转复,洋地黄转复慢性房颤疗效不佳;左房内径、房颤持续时间是影响转复成功的重要因素。  相似文献   
7.
OBJECTIVE: To evaluate the use of antidotal therapy in patients with an elevated digitalis concentration following chronic or acute exposure. DESIGN AND SETTING: Retrospective review of patient records over 2 years in 20 city hospitals in France. PATIENTS: Overall 838 patients with an elevated serum digitalis concentration (digoxin[Symbol: see text]>[Symbol: see text]1.95[Symbol: see text]ng/ml or digitoxin[Symbol: see text]>[Symbol: see text]23[Symbol: see text]ng/ml) were included in the study. Of these, 67 (8%) had received antidotal therapy with Fab fragments. MEASUREMENTS AND RESULTS: The relationships between previously reported prognostic criteria and use of antidotal therapy were investigated. We identified five independent factors that were associated with the use of antidotal therapy: acute overdose (OR 15.74), Fab fragment availability in the hospital (11.06), serum potassium (1.81), and heart rate (0.96). Mortality was significantly lower in Fab-treated (6%, 4/67) than untreated patients (15%, 117/770). CONCLUSIONS: Antidotal therapy is underused in patients with an elevated digitalis concentration especially in patients with chronic digitalis exposure. These patients in our series presented a higher mortality rate than patients with acute poisoning. Although they were older and tended to have a history of cardiac disease, they did not differ from patients with acute poisoning with regard to the main severity criteria and prognostic factors. The use of identical criteria for antidotal treatment after acute and chronic poisoning should help optimize outcomes. Fab fragment availability is insufficient in France but ranks only second after type of poisoning (acute or chronic) in the multivariate association with Fab treatment.  相似文献   
8.
冠心病患者的EDF昼夜节律与健康人的比较   总被引:1,自引:0,他引:1  
目的:了解冠心病人血中内生洋地黄因子(EDF)水平是否存在24h节律性变化及这种变化的特征和意义;方法:用放免法对20例冠心病人和9例“健康人”进行了24h血中EDF的动态监测;结果:发现冠心病患者血清EDF浓度有着与健康同龄人明显不同的昼夜节律性变化,其峰值在7:00,谷值在19:00,两者差别悬殊;结论:在对冠心病患者应用洋地黄类药物和检测血清地高辛浓度时,必须考虑到其EDF的这种特殊的变化规  相似文献   
9.
米力农与洋地黄治疗充血性心力衰竭的疗效比较   总被引:1,自引:0,他引:1  
目的探讨米力农与洋地黄治疗充血性心力衰竭的疗效。方法选择106例充血性心力衰竭患者,随机分为米力农组(38例)、洋地黄组(38例)和对照组(30例)。米力农组用米力农(10nag+生理盐水250m1)5-10mg·kg^-1·min。静滴;洋地黄组口服洋地黄(地高辛0.125--0.25mg/d);对照组仅口服和静注利尿剂和安慰剂,疗程均为10d。治疗前、后观察患者的心功能级别并做心脏超声心功能指数测定。结果米力农组心功能改善总有效率为89.47%,洋地黄组为81.58%,两组比较差异无统计学意义(P〉O.05),但米力农组明显高于对照组(36.67%)(P〈O.05)。两治疗组治疗后,心脏超声心功能指数有明显改善。结论米力农与洋地黄对治疗充血性心力衰竭有明显的疗效。  相似文献   
10.
The effects of toxic doses of ouabain on two parameters of mitochondrial activity, oxidative phosphorylation and calcium uptake were examined. Ouabain was injected intraperitoneally into guinea-pigs until signs of severe intoxication appeared. State 3 oxygen consumption (QO2, State 3, in natom oxygen/mg/min) of isolated heart mitochondria was 314 ± 16 and 281 ± 16 (glutamate-malate) for treated and control group, respectively; 225 ± 21 and 207 ± 23 (pyruvate-malate), and 251 ± 12 and 230 ± 13 (succinate), respectively. The rate of calcium uptake was 411 nmol Ca2+/min/mg for treated and 329.6 nmol Ca2+/min/mg for control. The rate of calcium release was the same in control and treated groups.The data suggest that increases of respiration and calcium uptake in vitro, if they reflect similar increases in vivo, may contribute to digitalis intoxication by intracellular redistribution of calcium.  相似文献   
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