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1.
目的探讨小儿肠胃康颗粒联合酪酸梭菌活菌散治疗小儿消化不良性腹泻的临床疗效及安全性。方法104例小儿消化不良性腹泻患儿,依据随机抽签法分为对照组与观察组,各52例。对照组采用小儿肠胃康颗粒治疗,观察组采用小儿肠胃康颗粒联合酪酸梭菌活菌散治疗。对比两组症状改善时间、治疗效果及不良反应发生情况。结果观察组腹泻、腹部疼痛及食欲下降改善时间分别为(1.93±1.05)、(2.05±1.06)、(2.47±1.04)d,均短于对照组的(4.88±1.49)、(3.62±1.55)、(3.63±1.15)d,差异有统计学意义(P<0.05)。观察组治疗总有效率为94.23%,高于对照组的76.92%,差异有统计学意义(P<0.05)。观察组不良反应发生率为1.92%,低于对照组的13.46%,差异有统计学意义(P<0.05)。结论小儿肠胃康颗粒联合酪酸梭菌活菌散治疗小儿消化不良性腹泻疗效显著,且安全性较高,值得临床合理推行实践。  相似文献   
2.
Tsukamurella species are obligate aerobic, gram-positive, weak acid-fast, nonmotile bacilli. They are found in various environments, such as soil, water, sludge, and petroleum reservoir wastewater, and belong to the order Actinomycetales. In 2016, there was a reclassification of species within the genus Tsukamurella, merging the species Tsukamurella tyrosinosolvens (T. tyrosinosolvens) and Tsukamurella carboxydivorans. Tsukamurella species are clinically considered to be a rare opportunistic pathogen, because most reported cases have been related to bacteremia and intravascular prosthetic devices and immunosuppression. To date, it has been isolated only from human specimens, and has always been associated with clinical disease; human infections are very rare. Reported infections have included pneumonia, brain abscesses, catheter-related bloodstream infections, ocular infections, bacteremia, and sepsis presenting with septic pulmonary emboli in patients who are immunocompromised. To date, there is no commercially available test for identification. On the other hand, sequence-based identification, including matrix-assisted laser desorption ionization time-of-flight mass spectrometry, is an alternative method for identifying clinical isolates that are either slow growers or difficult to identify through biochemical profiling. The golden standards for diagnosis and optimal management still remain to be determined. However, newer molecular biological techniques can provide accurate identification, and contribute to the appropriate selection of definitive therapy for infections caused by this organism. Combinations of several antimicrobial agents have been proposed for treatment, though the length of treatment for infections has yet to be determined, and should be individualized according to clinical response. Immunocompromised patients often experience severe cases due to infection, and life-threatening T. tyrosinosolvens events associated with dissemination and/or failure of source control have occurred. Favorable prognoses can be achieved through earlier identification of the cause of infection, as well as successful management, including appropriate antibiotic therapy together with source control. Further analyses of similar cases are required to establish the most adequate diagnostic methods and treatment regimens for infections.  相似文献   
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目的 构建基于百度指数的CEEMD - GRNN模型预测HIV感染病例数、为信息缺乏的HIV感染疫情预测提供可靠的方法,旨在为艾滋病流行趋势的传统预测方法提供有益补充。方法 第一,利用GRNN建立HIV感染病例数原始序列与百度指数的非线性关系;第二,先利用CEEMD提取HIV感染病例数的周期,再利用GRNN建立提取后序列与百度指数的非线性关系;第三,基于上述两种思想进一步建立组合预测模型,称为CEEMD - GRNN组合模型;最后,将CEEMD - GRNN组合模型应用于HIV感染病例数的预测。结果 模型拟合结果表明,最优单项模型的MAPE为10.17%,CEEMD - GRNN组合模型的MAPE为7.18%,组合模型的预测精度高于最优单项模型。结论 本文提出的CEEMD - GRNN组合模型预测精度优于最优单项模型,所提模型能够为信息不充足的非线性HIV感染病例数据提供稳定可靠的预测方法。  相似文献   
5.
BackgroundAbout 50% of Americans and 70% of US military service members (SMs) regularly use dietary supplements (DSs) and some are associated with adverse effects (AEs). SMs are more likely to use unsafe DSs than civilians.ObjectiveThe aim of this investigation was to examine the prevalence of, and factors associated with, AEs.DesignCross-sectional.ParticipantsA stratified random sample of 200,000 US SMs from the Air Force, Army, Marine Corps, and Navy were obtained from military workforce records. Eighteen percent (n = 26,681) of successfully contacted SMs (n = 146,365) volunteered to participate between December 2018 and August 2019. Participants completed a detailed online questionnaire on demographic characteristics, lifestyle factors, and AEs associated with DS use.Main outcome measurePrevalence of, and factors associated with, AEs among DS users.Statistical analysisPrevalence of AEs was calculated by DS categories. Linear trends, χ2 statistics, and multivariable logistic regression examined associations between AEs and demographic characteristics, lifestyle factors, and number DSs consumed.ResultsProportion of DS users (≥ 1 time /week) reporting ≥1 AE was 18% overall, 20% for combination products (ie, weight loss, muscle building, and before/after workout supplements), 8% for purported prohormones, 6% for protein/amino acid products, 6% for multivitamin/multiminerals, 6% for individual vitamins/minerals, 4% for herbal products, and 2% for joint health products. Combination products are very popular in military personnel with nearly half of SMs regularly taking them. In multivariable analysis, reporting AEs were independently associated with female gender, younger age, higher body mass index, smoking, higher alcohol intake, service in the Army, Navy, or Marine Corps (compared with Air Force), and consumption of a greater number of DSs.ConclusionsA large proportion of SMs report experiencing AEs, especially users of combination products and purported prohormone supplements. This study presents contemporary data collected from a very large at-risk population on potentially hazardous categories of DSs.  相似文献   
6.
《Drug discovery today》2022,27(12):103386
Inorganic nanoparticles for drug delivery in cancer treatment offer many potential advantages because they can maximize therapeutic effect through targeting ligands while minimizing off-target side-effects through drug adsorption and infiltration. Although inorganic nanoparticles were introduced as drug carriers, they have emerged as having the capacity for combined therapeutic capabilities, including anticancer effects through cytotoxicity, suppression of oncogenes and cancer cell signaling pathway inhibition. The most promising advanced strategies for cancer therapy are as synergistic platforms for RNA interference (siRNA, miRNA, shRNA) and as synergistic drug delivery agents for the inhibition of cancer cell signaling pathways. The present work summarizes relevant current work, the promise of which is suggested by a projected compound annual growth rate of ~ 20% for drug delivery alone.  相似文献   
7.
分析和探讨放射卫生机构在核辐射卫生应急体系中发挥的作用。通过对比发现,核辐射紧急医学救援基地多由取得放射卫生技术服务(甲级)资质或放射性疾病诊断机构资质的单位承担建设任务。放射卫生机构在平时工作中积累的辐射监测、污染检测、剂量估算、健康效应评价等技术能力可在核辐射卫生应急处置中发挥重要作用,实现能力建设的“平急结合”。建议各级放射卫生机构继续发挥自身所长,通过参加放射卫生监测项目的机会提高自身能力,并积极参与放射卫生技术机构检测能力考核,为核辐射卫生应急工作做好人才和技术储备。  相似文献   
8.
The emergence of carbapenem-resistant organisms posed considerable threat to global health while only limited treatment options are available and led to efforts to discover a novel way to treat them. To evaluate in vitro synergistic activity of meropenem plus ertapenem, a total of 203 carbapenem-resistant strains, collected from 12 provinces and municipalities in China, were examined with a dual carbapenem combination therapy. The statistical software R was used for analysis. Two hundred and one (201) of carbapenem-resistant strains mainly produced four types of carbapenemase: KPC-2 (n = 142, 69.95%), OXA-232 (n = 7, 3.45%), NDM (n = 38, 18.72%; 36 NDM-1, 1 NDM-4, 1 NDM-5), and IMP (n = 15, 7.39%; 1 IMP-26, 10 IMP-30, 4 IMP-4). Fifty-one out of two hundred and three (51/203 or 25.12%) of the examined strains showed a synergistic effect for the meropenem plus ertapenem combination throughout the checkerboard method, while only three isolates showed potential clinically relevant synergy (3/203, 1.48%). An additive effect was observed in 55/203 (27.09%) of the examined strains. Ninety-seven of the examined isolates (47.78%) showed fractional inhibitory concentration (FIC) greater or equal to 2 (indicating antagonism). The synergistic activity of meropenem plus ertapenem combination suggests this combination can be a possible way to treat the infection caused by the carbapenem-resistant organisms, especially for IMP or NDM producer with a lesser minimum inhibitory concentration (MIC) and the infected individual who was not recommended to use colistin or tigecycline.  相似文献   
9.
目的:分析《伤寒杂病论》中厚朴的量效关系及配伍用药规律,以更好地指导临床。方法:总结归纳《伤寒杂病论》中含有厚朴的条文,采用SPSS 23.0统计软件分析厚朴剂量与相关因素之间的关系。结果:符合筛选条件含厚朴方剂共11首,占全书总方剂数的9.73%。二元相关性分析显示,厚朴单次用量与药味数、用水量、与剩余水量、单次服用水量和服用次数无明显相关性(P>0.05)。单因素逻辑回归分析显示,厚朴是否为主药与厚朴单次用量、用水量有相关性(P<0.05)结论:厚朴以配伍用药为主,未单独使用,多应用在阳明经证,从量效关系发现,厚朴是否为主药与厚朴单次用量、用水量有相关性。厚朴对于虚实类疾病通过配伍均可达到治疗效果,从药物作用气机的升降浮沉角度,厚朴在体内作用以降为主。厚朴小剂量使用,配伍麻黄、杏仁、生姜、桂枝等可治疗呼吸系统疾病,大剂量配伍半夏、人参、生姜、枳实等可治疗消化系统疾病。  相似文献   
10.
目的评价蒲地蓝联合布地奈德治疗小儿急性咽喉炎的疗效。方法选取2018年1月-2019年12月间曾于我院就诊的102例小儿急性咽喉炎患者并根据其用药,将其分为对照组55例与观察组47例,除常规治疗外,对照组予布地奈德治疗,观察组予地蓝联合布地奈德治疗,观察对比两组疗效。结果观察组治疗总有效率为97.87%(46/47),显著高于对照组的83.63%(46/55),差异具有统计学意义(P<0.05);两组治疗中均无严重不良反应发生。结论蒲地蓝联合布地奈德治疗小儿急性咽喉炎的疗效显著,安全可靠,具有推广应用价值。  相似文献   
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