福建省新型冠状病毒肺炎中医证型探讨

按中医因地制宜的理论,根据武汉市与福建省不同的地理气候,福建省与武汉市新型冠状病毒肺炎中医证候差异,提出国家新型冠状病毒肺炎指南的证型不能完全覆盖福建省的全部病例,福建省应增加"湿热郁肺证",并提出"湿热郁肺证"的临床表现、治则治法与方药。     

The oncogenic impact of RNF2 on cell proliferation,invasion and migration through EMT on mammary carcinoma

Mammary carcinoma (MC) is one of most common malignancy in women, and ring finger protein 2 (RNF2) possesses various roles in vast human tumors. In MC tissues as well as in cell lines RNF2 exhibited high expression, had significant association with tumor size, lymph node status, TNM stage, patients’ poor survival, and promoted cell proliferation, colony formation, cell migration and invasion of MC cell lines which was mediated by downregulation of E-cadherin protein. These data reveal that RNF2 protein plays a vital role in the development of MC and may be a potential therapy target of MC.     

Genetic variants of DNA repair pathway genes on lung cancer risk

As is commonly perceived, polymorphisms in genes of deoxyribonucleic acid (DNA) repair pathway plays a fundamental role in defective DNA repair and mutagenesis prevention and serves to contribute to the individual susceptibility to the development of a variety of cancers. Recently, an increasing number of studies have been dedicated to the contentious and ambiguous links between polymorphisms in genes of DNA repair pathway and lung cancer (LC) risk. In response, a comprehensive updated meta-analysis has been proposed herein to assess the correlation between polymorphisms of DNA repair pathway genes and susceptibility to LC. This paper has identified and retrieved eligible articles from PubMed, Google Scholar, Web of Science, and CNKI databases till February 20, 2019. Finally, 295 case-control studies as to the fourteen polymorphisms of DNA repair pathway genes were enrolled. When the results have been pooled, we have brought to light the conclusion that ERCC2-rs13181 polymorphism has an elevated association with LC risk under allele, heterozygote, and dominant comparisons. In the subgroup analysis by ethnicity, we have found that the Caucasian individuals with “B” variant possess risk of LC which was more than twice as much as allele, homozygote, and recessive models. In comparison, Asian carriers of rs13181 polymorphism in ERCC2 gene are more susceptible to LC in heterozygote, dominant models. To sum up, ERCC2-rs13181 polymorphism could be a critical factor in stimulating LC evolvement. Future studies with a larger sample size and multivariate factors are needed to vindicate these findings.     

闽台两地“药缘”历史探析

闽台两地独特的地缘优势使得闽台中药文化交流频繁,在历史的演化、变迁过程中不断交融、发展,形成了闽台两地密切的“药缘”关系。本研究从闽台两地中药材贸易交流、“药签”的传播、人口迁徙带动中药交流与发展、具有药用价值作物的引种栽培,以及中药知识本土化融合发展几个方面,浅析闽台两地深厚的“药缘”历史,探究闽台中药文化渊源及其发展的推动力,为拓展与延伸闽台中药的交流合作提供借鉴与启示。     

四川省定向免费医学生政策的实践与探索

目的:从卫生政策研究和改进政策的角度出发,总结四川省农村订单定向免费医学生政策在推行中遇到的实际问题,为优化农村订单定向免费医学生政策在四川省的实施提供参考。方法:采用半结构式访谈对四川省、县市级卫生行政部门和基层医疗机构的定向培养政策主要负责人进行个人访谈,并采用焦点小组访谈了解定向生的思想动态。结果:定向生了解政策的渠道有限,对基层医生工作的理解不深,诚信档案未能切实发挥留住人才的作用;定向生考研意愿较高,但报考研究生与留任基层之间存在矛盾;对定向生的培养过程管理缺乏合理高效的模式。结论:应更注重培养定向生的荣誉感和责任意识,改进培养项目中的奖惩机制,优化管理考核模式,在促进各个政策参与部门之间工作衔接更加和谐有序的同时,更好地将定向生引入基层,从而优化基层卫生人力资源建设。     

黑龙江省12岁儿童患龋状况与饮水氟浓度关系的抽样调查

目的:研究黑龙江省不同地区12岁儿童龋齿和氟斑牙的发病情况与当地饮水氟浓度的关系。方法:按照WHO《口腔健康调查基本方法》的要求,采用多阶段分层等容量随机抽样方法,抽取全省城乡6个地区的12岁年龄组792例儿童进行龋齿和氟牙症调查。采用SPSS12.0软件包进行统计学分析。结果:6个地区饮水氟浓度分别为0.29、0.40、0.68、0.77、0.80和1.14mg/L;相应的患龋率为44.7%、43.2%、41.7%、37.1%、28.0%和40.5%。除饮水氟浓度1.14mg/L组外,随着饮水氟浓度的增高,患龋率有下降趋势,两者呈负相关关系(r=-0.81)。社区氟牙症指数(CFI)与饮水氟浓度呈正相关关系(r=0.78)。结论:适当的饮水氟浓度可有效降低龋齿的发病率,在水氟过高的情况下,可能会引起龋病和氟牙症的高发。     

陕西省新型冠状病毒传播与防控的回顾性分析

目的 分析陕西省严重急性呼吸综合征冠状病毒2(Severe Acute Respiratory Syndrome Coronavirus 2,SARS-CoV-2)的传播与防控措施,为当前的境外输入以及今后突发传染病的防控提供一定的理论指导。方法 整理陕西省卫生健康委员会网站公布的SARS-CoV-2流行、防控的相关资料,绘制病毒流行趋势图、传播网络图以及防控举措流程图。结果 陕西省SARS-CoV-2感染病例以输入病例为主(127/256,49.6%)。具有明确传播关系的病例共124例,主要因家庭密切接触和聚餐导致,跨市传播现象不明显;暂无境外输入关联本土病例;这与陕西省防控措施的全面落实关联密切。结论 提高民众特别是家庭成员的防控意识,对接触者实施早隔离、早追踪能有效地遏制SARS-CoV-2的暴发性流行。     

Association between Baseline SBP/DBP and All-Cause Mortality in Residents of Shanxi,China: A Population-based Cohort Study from 2002 to 2015

Objective To investigate the association between blood pressure and all-cause mortality in Shanxi,China.Methods The‘2002 China Nutrition and Health Survey’baseline data in Shanxi province was used.A retrospective investigation was performed in 2015.The effects of SBP and DBP on the all-cause mortality were analyzed using the Cox regression model.The hazard ratio(HR)and 95%confidence interval(CI)were estimated by the sex and age groups.Results The follow-up rate was 76.52%over 13 years,while the cumulative mortality rate for all participants was 917.12/100,000 person-years.The mortality rose with an increasing SBP(χ_trend²=270.537,P<0.001)or DBP level(χ_trend²=57.240,P<0.001).After adjustment for the confounding factors,a significant association between mortality and high SBP(≥160 mm Hg)and high DBP(≥100 mm Hg),with adjusted HR ranging from 1.405-to 2.179-fold for SBP and 1.550-to 2.854-fold for DBP,was noted.Significant HRs for most DBP subgroups were found in>60-year-old participants.Males with DBP≥100 mm Hg had a significantly higher mortality,with an HR(95%CI)of 2.715(1.377–5.351).Conclusion Adults with SBP>160 mm Hg and DBP>100 mm Hg had a higher mortality risk.Sex and age difference was noted in both DBP and mortality risk.     

四川省高校教师职业倦怠状况研究

目的对四川省高校教师职业倦怠状况进行抽样调查研究,揭示四川省高校教师存在职业倦怠的程度,为四川省高校教师队伍的管理与建设提供参考。方法于2013年12月,采用美国心理学家Maslach等编制的职业倦怠量表对随机抽取的520名四川省高校教师进行问卷调查。结果 1四川省高校教师职业倦怠的平均分为(1.440±0.486)分。2在去个性化维度上,不同性别(t=3.007,df=488,P=0.003)和年龄(F=4.801,df=3,P=0.003)的高校教师之间的差异有统计学意义。3在低成就感维度上,不同年龄(F=5.808,df=3,P=0.001)、学历(F=3.672,df=3,P=0.012)、职称(F=4.215,df=3,P=0.006)和收入(F=4.799,df=4,P=0.001)的高校教师之间的差异有统计学意义。结论 1四川省高校教师的职业倦怠水平较低。2年龄在46岁以上、或学历为博士、或职称为教授,或月收入在5000元以上的高校教师较少职业倦怠。