Supragaleal placement of tissue expander for post-burn alopecia.

Supragaleal placement of tissue expander for management of alopecia of scalp excludes tough galeal layer so that easier and faster expansion of scalp may be achieved.     

应用斑秃治疗仪治疗斑秃患者的疗效观察

目的对145例斑秃患者发病情况分析及治疗效果评价。方法采用问卷调查方式对门诊就诊的145例斑秃患者进行调查,收集斑秃患者发病可能或伴发因素,并根据调查及临床检查结果对145例斑秃患者随机分组,并分别采用斑秃治疗仪(治疗组)和胱氨酸、天麻首乌片口服治疗(对照组)。结果治疗组治愈率为94.2%、有效率为98.1%,对照组治愈率为71.4%、有效率为81.0%。结论斑秃治疗仪治疗斑秃疗效优于对照组。     

Protection against cyclophosphamide-induced alopecia by sulfhydryl-containing agents in the newborn rat animal model

Background Alopecia is a common side-effect of cancer chemotherapy. Although this complication has been known for many decades, little progress has been made in its prevention or treatment. Previously, we made the following observations: ( a ) treatment of 8-day-old rats with 1-0-n-arabinofuranosylcytosine (ara-C), doxorubicin, and cyclophosphamide (CYC) produced either total body alopecia (ara-C and CYC) or alopecia confined to the head and proximal part of the neck (doxorubicin); ( b ) Imuvert, a biological response modifier, and interleukin-1 protected against alopecia-induced by ara-C; and (c) neither Imuvert or interleukin-1 protected against CYC-induced alopecia. Objective Experiments were designed to test for agents to protect against CYC-induced alopecia. Methods Agents were tested in the 8-day-old rats as a model for chemotherapy-induced alopecia. Results Mesna and S-2-(3-aminopropylamino)-ethylphospnorothioic acid (WR-2721) did not offer any protection against chemotherapy-induced alopecia. N-Acetylcysterine offered very good protection against alopecia induced by CYC but not that produced by ara-C in the newborn rate animal model. Conclusion N-Acetylcysteine may prove to be important in the prevention of CYC-induced alopecia, but this needs to be tested in the clinical setting.     

Blood endotyping distinguishes the profile of vitiligo from that of other inflammatory and autoimmune skin diseases

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围刺飞针加电针治疗斑秃128例疗效观察

目的 :寻找治疗斑秃的有效方法。方法 :将斑秃患者 2 0 8例随机分为 2组。治疗组 1 2 8例采用围刺飞针加电针治疗 ,每日 1次 ,1 5次为一疗程 ;对照组 80例用内服中药治疗。结果 :治疗组总有效率为 86 7% ,对照组为 75 0 % ,两组总有效率比较 ,差异有非常显著性意义 (P <0 0 1 )。结论 :围刺飞针加电针治疗斑秃具有良好效果 ,其进针快 ,疼痛感较轻 ,安全 ,病人易接受 ,在临床上有推广价值。     

Treatment of Alopecia Areata with Plum-blossom Needles plus Moxibustion： A Report of 53 Cases

用梅花针叩刺斑秃区,后用艾条在患处温灸,治疗斑秃患者53例,并以口服薄芝片为对照治疗54例.3个疗程后前者总有效率为96.2%,后者为70.4%,两组疗效差异有统计意义.     

雄激素源性脱发

雄激素源性脱发是由雄性激素引起，为进行性的头发密度减少，其包括男性型脱发及女性弥漫性脱发，曾被强调与皮脂溢出有关。Hamilton和Kuster研究分别证实了雄激素源性脱发是一种雄性激素依赖的多基因遗传性脱发，为治疗男性脱发提供了依据。针对DHT的增高、受体的存在，应用5α还原酶的抑制剂、毛发移植取得了一定的效果。通过本文的阐述，与大家共同探讨。     

斑秃患者皮损处T淋巴细胞表型的研究及Fas的表达

目的　研究斑秃患者皮损处浸润T淋巴细胞的表型及Fas的表达情况。方法　应用免疫组织化学技术检测斑秃患者皮损处CD4和CD8T淋巴细胞及Fas的表达。结果　CD4和CD8:活动期和稳定期斑秃患者皮损处无论是毛囊周围还是血管周围CD4T淋巴细胞浸润数量均明显多于CD8T淋巴细胞 (P <0 .0 5 ) ;斑秃活动期的CD4和CD8T淋巴细胞浸润数量与稳定期和对照组相比较差异有统计学意义 (P <0 .0 5 )。Fas :与对照组相比较 ,斑秃患者皮损处毛囊角质形成细胞Fas的表达例数较多 (P <0 .0 5 )。结论　斑秃患者皮损处浸润T淋巴细胞以CD4T细胞占优势 ;Fas在斑秃皮损处毛囊角质形成细胞异常表达。