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1.
目的探讨超脉冲CO2点阵激光联合胶原贴敷料治疗面部痤疮瘢痕的临床效果。方法选取2020年1月至2021年1月宜阳县人民医院收治的60例面部痤疮瘢痕患者作为研究对象,并按照随机数表法将其随机分为观察组和对照组,每组30例,观察组患者采用超脉冲CO2点阵激光联合胶原贴敷料治疗,对照组患者单纯采用超脉冲CO2点阵激光治疗,对比两组患者面部美观度与皮肤屏障功能变化情况、临床疗效以及不良反应发生情况。结果治疗结束后,观察组患者面部皮肤毛孔值、纹理值以及经皮水分丢失(TEWL)、pH值、皮肤红斑指数均明显低于对照组(t=13.490、8.883、2.204、2.692、5.931,P<0.001、P<0.001、P=0.032、P=0.009、P<0.001),角质层含水量明显高于对照组(t=2.752,P=0.008);观察组患者中痊愈10例、显效12例、有效6例、无效2例,明显优于对照组患者的痊愈6例、显效7例、有效9例、无效8例(Z=-2.285,P=0.022);治疗期间,观察组患者不良反应发生率为6.67%,明显低于对照组患者的不良反应发生率30.00%(χ2=5.455,P=0.020)。结论超脉冲CO2点阵激光联合胶原贴敷料治疗面部痤疮瘢痕,可明显改善面部美观度和皮肤屏障功能,疗效显著,且胶原贴敷料可明显降低CO2点阵激光治疗造成的不良反应发生率。  相似文献   
2.
Background: Acne is a common and chronic inflammatory dermatosis of sebaceous gland units of the human hair follicle. Acne is closely related to immune cytokines and cells including T helper 17cells (Th17 cells). Mis-regulated glycolipid metabolism also plays a vital role in the process. Objective: This investigation aimed to explore the role of IL-17 in signaling pathways controlling sebaceous gland lipoprotein metabolism in a rat model of acne. Methods: We generated the rat ear acne model, and investigated the pathological changes of acne skin tissue by histological analysis and the changes in the critical factors including DEFB1, GPR65, FADS1, and FADS2 by Western Blot in this model. Results: There were more Th17 cells in the rat ear acne model than in the control mice. The expression levels of DEFB1, GPR65, FADS1, FADS2 and MOGAT1 were significantly upregulated in serum and tissue from rat acne model, which could be concluded that the Th17 cells play a major role in the pathogenesis of acne based. Conclusion: Although acne is associated with immune effects and glycolipid metabolism, inhibition of IL-17 signaling pathway might be a novel way for acne therapy. Our findings also suggest a new strategy for targeted therapy of acne.  相似文献   
3.

Introduction

Body dysmorphic disorder (BDD) is a mental health condition that is difficult to diagnose; it can cause a great deal of suffering, and treatment is often complex and challenging.

Material and method

The study population comprised 81 consecutive dermatology out-patients who met the inclusion criteria for participation. Participants were treated at hospitals in both urban (Zaragoza) and rural areas (Alcañiz). The project was based on a prospective and observational pilot study. Assessment instruments used: Cook's Acne Grading Scale and Body Dysmorphic Disorder Questionnaire (BDDQ) (Spanish translation).Possible cases of BDD were identified by means of 2 criteria: 1) A positive result in the BDDQ (4 positive points and a negative exclusion question); and, 2) A Cook's Acne Grading Score that reflected non-noticeable/mild lesions (the most stringent criteria) or moderate lesions (least stringent criteria)

Results

The age range of the patients was from 13 to 43 years old. The average age was 19 with a standard deviation of 6.2. Of the 81 participants, 54.3% were women. 61.7% were seen in a rural hospital (Alcañiz Hospital) and 38.3% in an urban one (University Hospital of Zaragoza). When more restrictive criteria regarding the seriousness of the condition were applied (only patients with mild acne), the BDDQ screening resulted in a positive BDD prevalence rate of 8.6% (7 patients); if the criteria were less restrictive (including patients with moderate lesions), the rate was 14.8% (12 patients).

Discusion

Patients who screened positive for BDD reported spending an average of 2 hours a day thinking and worrying about their appearance. These results highlight the importance of screening for possible cases of BDD in order to follow up these patients and recommend they be seen by a mental health specialist to confirm the diagnose and offer treatment for the disorder. BDD has a serious and negative impact on the lives of those affected.  相似文献   
4.
目的观察温针灸联合放血疗法对痤疮患者皮损程度、皮肤病生活质量指数(dermatology life quality index,DLQI)评分及复发率的影响。方法 120例湿热型痤疮患者随机分为观察组和对照组,每组60例。对照组采用放血疗法,观察组在对照组基础上联合温针灸治疗。观察两组患者治疗前后皮损程度、DLQI评分、中医症候评分变化,比较两组的临床疗效、不良反应发生率及复发率。结果观察组总有效率显著高于对照组(P<0.05)。两组治疗后皮损个数显著减少(P<0.05),且观察组皮损个数少于对照组(P<0.05),皮损减少率大于对照组(P<0.05)。治疗后两组DLQI评分、中医症候评分均显著降低(P<0.05),且观察组低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗组复发率显著低于对照组(P<0.05)。结论温针灸联合放血疗法治疗湿热型痤疮疗效佳,不良反应率低,复发率低,疗效稳定。  相似文献   
5.
ABSTRACT

Introduction: Acne vulgaris is a widespread skin disease. Topical therapy is a standard treatment for mild to moderate acne. Given the complex pathophysiology of acne, various agents with complementary action are nowadays frequently combined to increase the efficacy of therapy.

Area covered: This review focus on safety profile of topical agents used for the treatment of acne vulgaris, including topical retinoids, benzyl peroxide, azelaic acid, topical antibiotic, and combined agents. Data from clinical trials but also metanalyses, systematic reviews, and other secondary analyses are presented.

Expert opinion: In general, topical agents used for acne vulgaris have a favorable safety profile. The most commonly reported AEs were associated with local skin irritation, usually mild to moderate in intensity, intermittent, and rarely led to the cessation of therapy. Irritative potential seems to be highest for BPO and topical retinoids. Due to the possibility of development of Cutibacterium acnes resistance, topical antibiotics should not be used in monotherapy but as a part of combination therapy. In female adolescent and adults of childbearing potential, topical retinoids should be used with caution, because they are contraindicated in pregnant females (FDA Pregnancy category) C (adapalene, tretinoin) and X (tazarotene).  相似文献   
6.
【摘要】 目的 探究石榴皮多酚对大鼠耳廓痤疮模型的抗炎作用及机制。方法 将36只SPF级SD大鼠随机分为空白组、模型组、石榴皮多酚低、中、高浓度组和阳性组,除空白组外,其余各组于大鼠双耳内侧面耳导管开口处均匀涂抹100%油酸,0.5 ml/次,1次/d,并于涂抹油酸的第21天开始在大鼠耳廓同一部位皮下注射痤疮丙酸杆菌液50 μl,1次/d,连续3 d,构建大鼠耳廓痤疮模型。肉眼观察提示造模成功后外用药物,石榴皮多酚组予不同浓度(质量分数分别为1.4%、2.8%、5.6%)石榴皮多酚软膏0.5 mg,阳性组予盐酸克林霉素凝胶0.5 mg,空白组及模型组予等量蒸馏水,2次/d,连续用药2周。末次用药24 h后,取腹主动脉血,ELISA法检测大鼠血清中白细胞介素17(IL-17)水平;剪取大鼠耳廓模型处组织,HE染色观察各组皮肤组织病理学变化,免疫组化法检测局部组织中mTOR /HIF-1α/RORγt表达水平。对满足方差齐性的数据,采用单因素方差分析;对不满足的数据,采用Kruskal-Wallis H检验;两两比较采用LSD-t检验。结果 与模型组相比,石榴皮多酚组及阳性组大鼠耳廓造模处囊肿脱屑及痂皮明显改善,表皮角化改善,真皮层炎症因子浸润减少。IL-17水平在石榴皮多酚低浓度组(61.03 ± 5.99) ng/L、中浓度组(55.35 ± 2.24) ng/L、高浓度组(54.35 ± 4.29) ng/L、阳性组(48.11 ± 4.07) ng/L及空白组(42.10 ± 5.62) ng/L均明显低于模型组(70.24 ± 3.30) ng/L,t = 3.12、5.34、5.70、8.29、10.54,均P<0.05。免疫组化显示,HIF-1α表达水平在石榴皮多酚低浓度组(0.29 ± 0.05)、中浓度组(0.29 ± 0.03)、高浓度组(0.33 ± 0.02)及阳性组(0.30 ± 0.01)均明显低于模型组(0.41 ± 0.04),t值分别为4.89、5.50、3.62、5.21,均P<0.05;RORγt表达水平在石榴皮多酚低浓度组(0.28 ± 0.02)、高浓度组(0.31 ± 0.04)均低于模型组(0.35 ± 0.02),t值分别为3.68、2.18,均P<0.05;各组间mTOR表达差异无统计学意义(P = 0.119)。结论 石榴皮多酚可以改善大鼠痤疮模型炎症反应,其机制可能与下调HIF-1α/RORγt信号通路有关。  相似文献   
7.
Recommendations have been provided for the diagnosis and therapy of polycystic ovary syndrome in adolescence from 3 international expert conferences 2015-2018. Despite agreement about essentials, differences among details of these recommendations have engendered confusion. This commentary provides perspective about the agreements and disagreements among these recommendations and how these recommendations relate to other guidance. It concludes with practice suggestions that align with these recommendations.  相似文献   
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10.
Malassezia folliculitis is an under-recognized entity commonly affecting the face and upper trunk. Clinical picture mimics acne vulgaris and diagnosis is challenging at times. Ten percent potassium hydroxide examination is usually performed to confirm the diagnosis. This study sought to describe the dermoscopic features in Malassezia folliculitis. Patients diagnosed clinically with Malassezia folliculitis and confirmed by 10% potassium hydroxide preparation were included in the study. Dermoscopy was performed with a videodermatoscope (Dino-Lite AM413ZT; Polarizer) from the most representative lesion. A total of 45 patients (M:F = 1:0.8) were recruited. All patients had monomorphic papulo-pustular lesions. Itching was present in 64.4% patients. Dermoscopy reveled folliculocentricity (100%), perilesional background erythema (100%), dotted/linear/tortous vessels (88.9%), dirty white scaling (77.8%), hypopigmentation of hair follicle (64.4%), coiled/looped hairs (57.8%) and broken hairs (13.3%).In conclusion, dermoscopy shows typical features in Malassezia folliculitis and can serve as a office-based tool for identification of this entity.  相似文献   
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