有限元法生物力学分析在青少年特发性脊柱侧凸治疗及病因研究中的应用

青少年特发性脊柱侧凸发病率较高且病情复杂,对青少年身心健康可造成显著影响,但其因病因不明,临床尚未形成治疗共识。近年来基于患者医学影像进行仿真建模的有限元法生物力学分析在青少年特发性脊柱侧凸治疗及其病因研究中已经有了一系列的应用。本文即从非手术治疗、手术治疗、病因研究、现有局限等角度对有限元法生物力学分析在青少年特发性脊柱侧凸中的应用进行综述,以期为临床实践及相关研究提供参考。     

IL-37b作用于树突状细胞CD39/ATP轴抑制类风湿性关节炎大鼠炎症反应的作用及机制

目的探讨白细胞介素37b重组蛋白(rmIL-37b)通过调节CD39/ATP轴抑制树突状细胞(DC)诱导类风湿性关节炎(RA)大鼠炎症反应的机制。方法将SD大鼠随机分为空白对照组(CTL)、CIA模型组、rmIL-37b 5μg/kg组、rmIL-37b 10μg/kg组,每组各10只。除了空白对照组外,其余大鼠采用含有卡介苗的完全弗氏佐剂和牛Ⅱ型胶原混合乳液免疫刺激,建立CIA模型。确定建模成功当天(D0),rmIL-37b组分别尾静脉注射5μg/kg、10μg/kg rmIL-37b;CTL组和CIA模型组注射相同体积的(1 ml/kg)生理盐水,连续给药15 d。免疫组化法检测滑膜组织Nod样受体蛋白3(NRPL3)炎症小体的表达,流式细胞术检测DC表型,另外试剂盒检测血清三磷酸腺苷(ATP)和免疫学指标。结果与CIA模型组相比,rmIL-37b 10μg/kg组大鼠足容积、AI值、NLRP3炎症小体表达量、血清ATP、IL-1β、IL-18、肿瘤坏死因子α(TNF-α)、抗Ⅱ型胶原抗体亚型(anti-ColⅡ-IgG、anti-ColⅡ-IgG2a)水平均降低,同时DC表面CD...     

Age estimation of Iraqi children and young adults based on third molar development and its relation to chronological age

ObjectivesThe study aimed to estimate the age of Iraqi children and young adults based on the third molar development to establish Iraqi reference material for orthodontic and forensic purposes, and to investigate the correlation between the estimated and chronological age.MethodsA retrospective analysis of digital orthopantographs of 1515 patients of Iraqi origin, aged from 6 to 25 years was conducted, and the developmental status of the mandibular right third molar for each patient was evaluated using Demirjian et al.’s method. Statistical analysis was carried out using “Mann-Whitney U-test” between genders. The linear regression analysis was performed to obtain “regression formulas” for dental age calculation with chronologic age.ResultsNo statistically significant differences were observed between Iraqi males and females at any age. The median of male and female age of initial calcification of the cuspal tips for mandibular third molars was 9 years, whereas 14 years was the median of age for both genders when the crown was completed. All mandibular right third molars have a complete root formation with apex closure at a median of male and female age 22 years.ConclusionsThe use of Demirjian et al.’s method was appropriate as a reliable age indicator for Iraqi population. A strong correlation was observed between these stages and chronological age. Consequently, reference data have been established for mandibular third molar development in Iraqi population.     

基于红外热成像技术探讨扶正温阳法对阳虚体质的影响

目的 基于红外热成像技术探讨“扶正温阳法”对阳虚质的影响，探讨阳虚质者红外热图的共性规律，分析判断“扶正温阳法”干预阳虚质人群的疗效。方法 纳入30例阳虚质患者给予益气温阳药物在大椎、肾俞（双侧）、命门等进行穴位贴敷，分别在干预前后运用红外热成像技术测定督脉、腰部、腹部、双手及双足局部温度的变化。结果 干预后阳虚体质患者的督脉、腰部、腹部、双手、双足温度均升高（P<0.05），阳虚体质局部温度得以改善。结论 本研究发现“扶正温阳法”可诱发循经热传导现象，通过调节热能代谢而起到调治阳虚体质的作用，红外热成像技术可用来辅助评价阳虚质的治疗效果，对临床指导制定阳虚质人群的干预方案疗效判定具有指导意义。     

中医移动医疗App信息服务现状研究

以“七麦数据”网站收录的中医移动医疗App作为研究对象，采用网络调查法和文献分析法，根据“七麦数据”对移动医疗App的分类，结合中医移动医疗App的信息服务内容和特点，将筛选出的中医移动医疗App划分为医疗健康类、中医养生类、知识传播类、全面综合类，并根据“七麦数据”网站中对各类中医移动医疗App的打分及累计下载量筛选出最具代表性的12款中医移动医疗App，从全面性、人性化、安全性、实用性4个一级指标和40个二级指标对其信息服务现状进行评价，指出当前中医移动医疗App信息服务存在的问题并提出建议。     

High Order Finite Difference Hermite WENO Fixed-Point Fast Sweeping Method for Static Hamilton-Jacobi Equations

In this paper, we combine the nonlinear HWENO reconstruction in [43] and the fixed-point iteration with Gauss-Seidel fast sweeping strategy, to solve the static Hamilton-Jacobi equations in a novel HWENO framework recently developed in [22]. The proposed HWENO frameworks enjoys several advantages. First, compared with the traditional HWENO framework, the proposed methods do not need to introduce additional auxiliary equations to update the derivatives of the unknown function $\phi$. They are now computed from the current value of $\phi$ and the previous spatial derivatives of $\phi$. This approach saves the computational storage and CPU time, which greatly improves the computational efficiency of the traditional HWENO scheme. In addition, compared with the traditional WENO method, reconstruction stencil of the HWENO methods becomes more compact, their boundary treatment is simpler, and the numerical errors are smaller on the same mesh. Second, the fixed-point fast sweeping method is used to update the numerical approximation. It is an explicit method and does not involve the inverse operation of nonlinear Hamiltonian, therefore any Hamilton-Jacobi equations with complex Hamiltonian can be solved easily. It also resolves some known issues, including that the iterative number is very sensitive to the parameter $ε$ used in the nonlinear weights, as observed in previous studies. Finally, to further reduce the computational cost, a hybrid strategy is also presented. Extensive numerical experiments are performed on two-dimensional problems, which demonstrate the good performance of the proposed fixed-point fast sweeping HWENO methods.     

CRISPR-Cas系统在动物及植物中不同的递送方式研究进展*

CRISPR-Cas 系统的发现彻底改变了基因编辑技术领域，在多方面都有着广阔的前景。该系统主要有Cas 蛋白和单链向导RNA 组成，其功能的发挥高度依赖于各组分的有效递送。本篇综述对目前动植物中该系统组分 的常用递送方式进行详细总结，并分析其目前仍存在的问题。     

导引功法结合腹部按摩预防亚健康人群向慢性疲劳综合征转化的临床研究

摘要：目的 观察导引功法结合腹部按摩预防亚健康人群向慢性疲劳综合征转归的临床疗效。方法 将纳入研究的144例患者随机分成观察组（n=72）和对照组（n=72），两组患者均给予标准化的健康教育干预，在此基础上观察组运用导引功法结合腹部按摩干预，2组疗程均为12周，分别在干预前、干预后采用疲劳评定量表（FSS）、中医症候积分量表及生活质量量表（SF-36）进行评价。结果 两组各随机选完成研究的36例进行组内比较：两组均较干预前显著改善，有统计学意义（P＜0.05）；组间比较：干预后，观察组疲劳评定总分和中医症候积分显著低于对照组，生活质量评分高于对照组，均有统计学意义（P＜0.05）。结论 导引功法结合腹部按摩预防亚健康人群向慢性疲劳综合征转归效果明显，能有效摆脱疲劳状态，提高生活质量，值得临床推广应用。