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Objective: To investigate the changes of the plasma level of MMP-9 ( Matrix Metalloproteinase-9, MMP-9) in the patients with abdominal aortic aneurysms ( AAAs) before and after the treatment, and evaluate the significance of MMP-9 in the pathogenesis of AAAs. Methods: Blood samples of 35 patients with AAAs and 10 patients with the arterial occlusive diseases ( AODs) , which enrolled into the Vascular Surgery Center of Colonge University Hospital from February to August of 2002, were collected before and one month after surgical repair or less-invasive endovascu-lar exclusion. The plasma concentrations of MMP-9 of all the collected samples were measured by means of enzyme-linked immunosorbent assay ( ELISA) , and compared between the two groups patients at different time point. Results: The mean plasma concentration of MMP-9 of AAAs was significantly higher than that of AODs prior to treatment [(90.3±9.1) ng/ml vs (23. 6±7. 3) ng/ml, P < 0. 05 ] , and no apparent difference was showed in the patients w  相似文献
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