全文获取类型
收费全文 | 66309篇 |
免费 | 5022篇 |
国内免费 | 2088篇 |
专业分类
耳鼻咽喉 | 794篇 |
儿科学 | 1029篇 |
妇产科学 | 828篇 |
基础医学 | 12045篇 |
口腔科学 | 1061篇 |
临床医学 | 4435篇 |
内科学 | 10494篇 |
皮肤病学 | 1355篇 |
神经病学 | 5536篇 |
特种医学 | 1302篇 |
外国民族医学 | 16篇 |
外科学 | 5041篇 |
综合类 | 7072篇 |
一般理论 | 4篇 |
预防医学 | 2929篇 |
眼科学 | 1027篇 |
药学 | 10630篇 |
20篇 | |
中国医学 | 2829篇 |
肿瘤学 | 4972篇 |
出版年
2023年 | 1373篇 |
2022年 | 2108篇 |
2021年 | 3122篇 |
2020年 | 3111篇 |
2019年 | 3528篇 |
2018年 | 3484篇 |
2017年 | 3166篇 |
2016年 | 2544篇 |
2015年 | 2516篇 |
2014年 | 3828篇 |
2013年 | 5202篇 |
2012年 | 4507篇 |
2011年 | 4246篇 |
2010年 | 3296篇 |
2009年 | 3165篇 |
2008年 | 2921篇 |
2007年 | 2645篇 |
2006年 | 2350篇 |
2005年 | 1921篇 |
2004年 | 1804篇 |
2003年 | 1502篇 |
2002年 | 1134篇 |
2001年 | 877篇 |
2000年 | 850篇 |
1999年 | 667篇 |
1998年 | 576篇 |
1997年 | 593篇 |
1996年 | 491篇 |
1995年 | 588篇 |
1994年 | 497篇 |
1993年 | 418篇 |
1992年 | 348篇 |
1991年 | 328篇 |
1990年 | 291篇 |
1989年 | 243篇 |
1988年 | 185篇 |
1987年 | 188篇 |
1986年 | 192篇 |
1985年 | 380篇 |
1984年 | 420篇 |
1983年 | 265篇 |
1982年 | 302篇 |
1981年 | 242篇 |
1980年 | 205篇 |
1979年 | 163篇 |
1978年 | 119篇 |
1977年 | 116篇 |
1976年 | 129篇 |
1975年 | 93篇 |
1974年 | 47篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
《Research in social & administrative pharmacy》2022,18(9):3694-3698
In this paper, we argue that understanding and addressing the problem of poor-quality medical products requires a more interdisciplinary approach than has been evident to date. While prospective studies based on rigorous standardized methodologies are the gold standard for measuring the prevalence of poor-quality medical products and understanding their distribution nationally and internationally, they should be complemented by social science research to unpack the complex set of social, economic, and governance factors that underlie these patterns. In the following sections, we discuss specific examples of prospective quality surveys and of social science studies, highlighting the value of cross-sector partnerships in driving high-quality, policy-relevant research in this area. 相似文献
2.
目的比较飞秒激光制瓣准分子激光原位角膜磨镶术(FS-LASIK)、全飞秒激光小切口角膜基质透镜取出术(SMILE)和有晶状体眼后房型人工晶状体(ICL V4c)植入术三者矫正中低度近视的效果。方法采用回顾性研究。以惠州爱尔眼科医院2019年6月至2020年4月矫正中低度近视120例(120眼)作为研究对象,受术者分为FS-LASIK组、SMILE组及ICL组,每组40例(40眼),各组分别接受相应的手术,术后随访3个月比较其矫正效果。结果术后1个月及3个月,3组间视力及有效性指数对比差异无统计学意义(P>0.05);ICL组安全性指数高于SMILE组及FS-LASIK组(P<0.05)。术后3个月FS-LASIK组的三叶草像差、彗差和球差出现明显变化,而SMILE组的变化较小,ICL组变化最小(P<0.05)。结论对中低度近视FS-LASK、SMILE及ICL植入术三者均有确切疗效,而ICL V4c植入术的安全性最高,患者的视觉质量最好。 相似文献
3.
4.
胶质淋巴系统是一个主要由星形胶质细胞水通道蛋白4介导的依靠动脉、静脉周围血管间隙的脑脊液-脑组织液交换流动的系统,是阿尔茨海默病、脑卒中、帕金森病、失眠、抑郁症等脑病的共同特征,是一条新的脑代谢途径,可以清除包括β-淀粉样蛋白、乳酸在内的代谢产物。本文综合分析了全球有关胶质淋巴系统在脑部疾病的研究,得出:胶质淋巴系统可能为神经退行性疾病等发病机制和诊治策略研究带来新视角;胶质淋巴系统有望为一些脑部疾病诊断提供新的有效证据;胶质淋巴系统可能是脑部疾病治疗给药方式的新途径。 相似文献
5.
6.
《Digestive and liver disease》2022,54(11):1486-1493
BackgroundCold snare polypectomy (CSP) is a promising technique for the removal of sessile serrated polyps (SSPs) ≥ 10 mm. However, the efficacy and safety of this technique remain undetermined.AimsWe aimed to comprehensively evaluate the efficacy and safety of CSP for SSPs ≥ 10 mm.MethodsPubMed, EMBASE, Web of Science and Cochrane Library were searched up to January 2021.ResultsA total of 10 studies consisting of 1727 SSPs (range, 10–40 mm) from 1021 patients were included. The overall rates of technical success, adverse events (AEs) and residual SSPs were 100%, 0.7% and 2.9%, respectively. Subgroup analysis showed that the rates of technical success and AEs were comparable between CSP and cold endoscopic mucosal resection (EMR) (99.9% vs. 100% and 1.3% vs. 0.5%, respectively), between the proximal and distal colon (100% vs. 99.9% and 0.3% vs. 0, respectively), and between polyps of 10–19 mm and ≥20 mm (99.8% vs. 100% and 0.9% vs. 0, respectively). However, subgroup analysis showed that the rate of residual SSPs was slightly lower in CSP compared with cold EMR (1.3% vs. 3.9%), as well as in polyps of 10–19 mm compared with those ≥20 mm (3.1% vs. 4.7%).ConclusionCSP was an effective and safe technique for removing SSPs ≥ 10 mm. 相似文献
7.
《Cancer radiothérapie》2022,26(3):502-516
The aim of the review was to present the current literature status about replanning regarding anatomical and dosimetric changes in the target and OARs in the head and neck region during radiotherapy, to discuss and to analyze factors influencing the decision for adaptive radiotherapy of head and neck cancer patients. Significant progress has been made in head and neck patients’ evaluation and qualification for adapted radiotherapy over the past ten years. Many factors leading to anatomical and dosimetric changes during treatment have been identified. Based on the literature, the most common factors triggering re-plan are weight loss, tumor and nodal changes, and parotid glands shrinkage. The fluctuations in dose distribution in the clinical area are significant predictive factors for patients’ quality of life and the possibility of recovery. It has been shown that re-planning influence clinical outcomes: local control, disease free survival and overall survival. Regarding literature studies, it seems that adaptive radiotherapy would be the most beneficial for tumors of immense volume or those in the nearest proximity of the OARs. All researchers agree that the timing of re-planning is a crucial challenge, and there are still no clear consensus guidelines for time or criteria of re-planning. Nowadays, thanks to significant technological progress, the decision is mostly made based on observation and supported with IGRT verification. Although further research is still needed, adaptive strategies are evolving and now became the state of the art of modern radiotherapy. 相似文献
8.
9.
The objective of the present study was the development and validation of the method for determining AMB-FUBINACA and its metabolite - AMB-FUBINACA O-desmethyl acid – in blood samples, followed by verification of the method in toxicological judicial and forensic medicine practice employing the example of post-aggression suicide. Most likely in consequence of development of adverse effects resulting in psychotic symptoms, a male being under the influence of the synthetic cannabinoid AMB-FUBINACA and the new synthetic opioid U-47700, mortally wounded his female partner and subsequently committed suicide. Identification and determination of the afore-mentioned xenobiotics in blood samples collected from the male and female victims were performed employing high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). The analytes were isolated from blood samples using the solid phase extraction (SPE) method. The blood samples collected from the male and female demonstrated respectively 110 and 196 ng/mL of AMB-FUBINACA O-desmethyl acid metabolite, 1935 and 357 ng/mL of U-47700, 250 and 200 ng/mL of N-desmethyl-U-47700, as well as 410 and 200 ng/mL of N,N-didesmethyl-U-47700. The concentration values of new psychoactive substances (NPS’s) in blood samples originating from the male and female were within the ranges encountered in cases of poisoning, including these resulting in death. Nevertheless, the evident signs of exsanguination proof that the woman was alive when she sustained lethal injuries. The presented cases illustrate the difficult to be anticipated effect exerted on the users by NPS’s. 相似文献
10.