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1.
"中式鸡尾酒疗法"防治艾滋病   总被引:4,自引:0,他引:4  
从艾滋病发现以来,全世界已经有6000万人感染了艾滋病毒,截止2004年为止,已经有2000万人死于艾滋病。而仅仅在2003年1年,就有480万人新感染了艾滋病毒,超过了以往的任何一年。因此,对艾滋病的预防和治疗更加刻不容缓。而对于西药治疗艾滋病中日益严重的毒副作用、耐药性等问题,  相似文献
2.
Background The immunological differences between children and adults with AIDS in China are not well documented. Th1/Th2 cytokines and chemokines are two types of immune factors intimately involved in disease progression of HIV-1 infection. This study aimed to identify changes in plasma levels of Th1/Th2 cytokines inerleukin (IL)-18, IL-16, IL-10 and chemokines regulated on activation, normal T cell expressed and secreted (RANTES), stromal cell-derived factor-1 (SDF-1) and monocyte chemoattractant protein-1 (MCP-1) in HIV-l-infected children and adults in China. Methods Seventy-five children with AIDS and 35 adult AIDS patients were recruited and clinical data were collected. CD4^+ T lymphocyte counts were measured by flow cytometery and plasma HIV RNA levels were measured by quantitative RT-PCR. Plasma levels of IL-18, IL-10, IL-16, RANTES, MCP-1, SDF-1a and SDF-1β were quantified by enzyme-linked immunosorbent assay. The levels of β2-microglobulin (β2-MG) and soluble Fas (sFas) were measured to validate the level of humoral and cellular immune activation. Results The mean levels of all cytokines in pediatric and adult AIDS patients were significantly higher than in their healthy controls (P 〈0.01). The mean levels of these cytokines were higher in pediatric patients than in adult patients (P 〈0.05, except for SDF-la and β2-MG). Some of the cytokine levels in patients younger than 6 years old was higher than in older children and adults with AIDS (IL-10, IL-18, SDF-la, MCP, RANTES and sFas, P 〈0.05). Levels of IL-18, IL-10, RANTES and β2-MG of pediatric patients increased as the levels of viral load increased (P 〈0.05). Conclusions Abnormal immune activation can be measured in Chinese pediatric and adult patients with AIDS, and is higher in children than in adult patients. The cytokines levels coincide with disease progression of AIDS, but have no direct relationship with total CD4^+ T cell count.  相似文献
3.
目的探讨患者术前检测艾滋病毒抗体、丙型肝炎抗体和梅毒螺旋体抗体的临床意义。方法采用ELISA方法对4124例孕产妇及外科手术前患者做艾滋病毒抗体、丙型肝炎抗体、梅毒螺旋体抗体的检测。结果4124例检测样本中艾滋病毒感染阳性率为0.048%,丙型肝炎病毒感染阳性率为1.6%,梅毒螺旋体感染阳性率为0.58%。结论手术前及孕产妇做艾滋病毒抗体、丙型肝炎抗体和梅毒螺旋体抗体的检测,对避免院内感染和交叉感染,防止病毒进一步传播,有着重要的临床意义。  相似文献
4.

Background  Factors of cell-mediated immunity and allergy together play their roles in the pathogenesis of pulmonary tuberculosis (PTB) and its prognosis. The purpose of this study was to investigate the computed tomographic demonstrations of HIV seropositive PTB and the relationship between its pathogenesis and CD4+ T-lymphocyte count.

Methods  The documented CT images of a total of 44 patients with HIV seropositive PTB, definitely diagnosed by etiological or pathological examinations, their clinical data and their CD4+ T-lymphocyte count were retrospectively reviewed.

Results  There were 15 cases of miliary tuberculosis, accounting for 34.1% of the total cases; 15 cases of nodular tuberculosis, 34.1%; 6 cases of ground-glass opacity, 13.6%; 5 cases of cord-liked fiber shadows, 11.4%; 16 cases of flaky and flocculating shadows, 36.4%; 5 cases of cavitation, 11.4%; 5 cases of tumor shadows, 11.4%; 2 cases of pleural thickening, 4.5% and 11 cases of pleural effusion, 25.0%; 1 case of calcification, 2.3%; 16 cases of lymphadenectasis, 36.4%. The foci were located around the pulmonary hilum, anterior segment of superior lobe, basal segment of inferior lobe, medial lobe and lingual lobe. CD4+ T-lymphocyte count was closely related to the imaging demonstrations of HIV seropositive PTB.

Conclusions  CT scanning can demonstrate various signs of PTB. CD4+ T-lymphocyte level determines the variety of imaging demonstrations of HIV seropositive PTB and its prognosis.

  相似文献
5.
Background  Recent studies have reported overall increasing rates of syphilis with a high rate of human immunodeficiency virus (HIV) co-infection. However, there is little information about factors influencing syphilis treatment failure and/or re-infection in HIV co-infected patients. We conducted a study to evaluate factors associated with syphilis treatment failure/re-infection in HIV co-infected patients.
Methods  We reviewed 3542 medical records of HIV-infected patients from January 2005 to December 2007 followed up at HIV Clinic in New York City. Patients were categorized by rapid plasma regain titer (RPR) into success/serofast (4-fold decrease in RPR by 12 months after treatment, RPR conversion to nonreactive, persistently stable reactive RPR with no 4-fold increase), and failure/re-infection (failure to decrease 4 folds in RPR by 12 months after treatment, 4-fold increase in RPR from baseline).
Results  Among a total of 156 patients who met the eligibility criteria, 122 (78.2%) were under success/serofast category, and 34 (21.8%) were under failure/re-infection category. HIV viral load, CD4 cell count, and use of highly active antiretroviral therapy (HAART) were not associated with syphilis treatment failure/re-infection. However, early syphilis stage (OR: 11.036, 95% CI: 2.499–48.740, P=0.002) and high (>1:64) RPR titers (OR: 715.921, 95% CI: 422.175–23 113.396, P <0.001) were significantly associated.
Conclusions  No correlations were seen with depressed immune states with syphilis treatment failure and/or re-infection. However, association with early stage syphilis suggests that risky psychological sexual behaviors may be the most important leading factor, emphasizing needs for safe sex education.
  相似文献
6.
Background Increased risk of atherosclerosis has been reported in patients with human immunodeficiency virus (HIV)infection since highly active antiretroviral therapy (HAART) has come into use. However, there is no clear evidence of premature atherosclerosis in Chinese HIV-infected patients. Our study was designed to determine the relationship between HIV infection and atherosclerosis in Chinese HIV-infected patients.Methods One hundred and forty-five patients were enrolled in this study. These included 82 HIV-infected patients (41HAART-treated and 41 antiretroviral therapy (ART) naive patients) and 43 HIV-negative control subjects. Data on traditional cardiovascular risk factors, HIV infection parameters, and treatment regimens were collected. Pulse wave velocity (PWV) was determined using a pulse pressure analyzer to evaluate the function of the arterial wall as an indicator of atherosclerotic vascular damage.Results A higher PWV ((1358.3±117.8) cm/s vs. (1270.2±189.2) cm/s, P=0.010) was found in ART na(i)ve HIV-infected patients compared with control subjects. However, HAART treated patients had lower PWV compared to ART na(i)ve patients ((1283.8±181.4) cm/s vs. (1358.0±117.8) cm/s, P=0.033). Multiple regression analysis revealed that age (B=5.218, 95% confidence interval (CI) 1.420-9.016, P=0.008), current smoking (B=-74.671, 95% CI -147.003 to -2.339, P=0.043) and HAART (92.7% patients on a protease inhibitor-free regimen) (B=-169.169, 95% CI-272.508 to -65.831, P=0.010) were associated with reduced PWV in HIV-infected patients.Conclusions Reduced PWV in HIV-infected Chinese patients indicates that they are more likely to develop arterial wall stiffness, possibly by atherosclerosis. A protease inhibitor-free regime may be protective for arterial wall of HIV infected patients.  相似文献
7.
China's rapidly evolving HIV/AIDS epidemic calls for a dramatic expansion of both prevention and treatment services. Official state media recently reported that for the first time, in 2008, HIV/AIDS became China's leading cause of death among infectious diseases. Estimates from the Ministry of Health indicate that around 700 000 people were living with HIV and 85 000 people had AIDS in 2007. Initially, HIV-1 infection was confined primarily to certain high-risk populations such as injection drug users (IDU) along drug-trafficking routes, and former plasma donors (FPD) in rural communities in east-central China. Now, however, HIV prevalence is increasing among female sex workers (FSW) and men who have sex with men (MSM).  相似文献
8.
抗人免疫缺陷病毒中药复方研究进展   总被引:1,自引:0,他引:1  
艾滋病的病程复杂多变,而中药复方是中医治疗艾滋病最有效的形式之一,能最大限度地提高药物疗效和降低毒副作用.中药复方治疗艾滋病的有效形式主要有:降低患者病毒载量、提高CD4^+T细胞数;提高患者免疫系统;改善患者临床症状.我们对近年来在临床上应用较有效的抗艾滋病中药复方进行归纳总结,找出了其中的一些规律,以期对寻找和运用中药复方治疗艾滋病有所启发.  相似文献
9.
妊娠合并HIV感染剖宫产术中自我防护的体会   总被引:1,自引:0,他引:1  
刘冬梅 《广西医学》2007,29(9):1456-1456
随着艾滋病在全球的蔓延,妊娠合并HIV感染者呈逐年上升趋势.目前剖宫产已成为HIV阳性孕妇普遍采用的生产方式,对欧洲5项、北美洲10项总数超过8 500对母婴的前瞻性研究,经过婴儿体重、母亲HIV感染持续时间和抗逆转录病毒治疗等因素校正后发现,剖宫产可以使HIV的母婴传播危险性降低50%以上[1].  相似文献
10.
艾滋病毒携带者合并烧伤的护理   总被引:1,自引:1,他引:0  
目前全球艾滋病毒携带者已有3000万,我国爱滋病毒携带者已达85万。随着艾滋病毒携带者的增多,医务人员在医疗环境中感染HIV的危险性增加,医护人员如何在工作中既尽到自己的职责又能保护自己不被感染是目前值得注意的问题。现就本科收治的烧伤患者中1例艾滋病毒携带者的护理,报道如下。  相似文献
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