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空气负离子发生器已广泛应用于临床,它在防治疾病上的意义已日益受到人们的重视。为了探讨其效应机理,作者曾观察到狗血淋巴细胞经一定浓度的空气负离子处理后,其细胞活存时间延长并使放射损伤的致死效应减轻。在此基础上又观察了狗离体血淋巴细胞~(80)Coγ线损伤后,空气负离子对其细胞活力的作用,结果如下。  相似文献
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本文研究了氚标记胸腺嘧啶核苷(8H-TdR)静脉注射后在BALB/C 纯种幼年和成年小白鼠睾丸中的代谢差异及其对成年雄性生殖细胞的损伤效应。注入0.037MBq/g 体重~3H-TdR 后,氚在成年鼠睾丸中的初始负荷量大于幼年鼠,但幼年鼠氚滞留量随时间延长渐渐超过成年鼠。~3H-TdR 可引起成年雄性生殖细胞损伤,表现为显性致死和显性骨骼突变的发生率增高。显性致死的致突变指数Y 与注射~3H-TdR 放射性活度I 的关系为Y=74.13+80.20I;显性骨骼突变发生率B 与注入~3H-TdR 放射性活度I 的关系为B=0.16+7.95×10_(-2)I。  相似文献
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在CFU-GM培养过程中,事先对骨髓细胞施加:①3.5Gy射线照射;②44℃60min热处理;③-20℃16min冷处理,都能使CFU-GM产率下降。在培养前用胎肌液(FME)处理骨髓细胞,可以使CFU-GM产率增高。证明FME有非特异性的减弱物理因子对CFU-GM的损伤作用的能力。  相似文献
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The roles of voltage-dependent K^+ channels during activation and damage in alveolar macrophages (AMs) exposed to different silica particles were examined. Rat AMs were collected by means of bronchoalveolar lavage, and were adjusted to 5× 10^5/mL. After AMs were exposed to different concentrations (0, 25, 50, 100, 200 μg/mL) of quartz particles and 100 μg/mL amorphous silica particles for 24 h, the voltage-depended K^+ current in AMs was measured by using patch clamp technique. Meanwhile the leakage of lactate dehydrogenase (LDH) and the viability of AMs were detected respectively. Patch clamp studies demonstrated that AMs possessed outward delayed and inward rectifying K^+ current. Exposure to quartz particles increased the outward delayed K^+ current but it had no effect on inward rectifier K^+ current in AMs. Neither of the two K^+ channels in AMs was affected by amorphous silica particles. Cytotoxicity test showed that both silica particles could damage AM membrane and result in significant leakage of LDH (P〈0.05). MTT studies, however, showed that only quartz particles reduced viability of AMs (P〈0.05). It is concluded that quartz parti- cles can activate the outward delayed K^+ channel in AMs, which may act as an activating signal in AMs to initiate an inflammatory response during damage and necrosis in AMs induced by exposure to quartz particle. K^+ channels do not contribute to the membrane damage of AMs.  相似文献
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