Sex-biased autophagy as a potential mechanism mediating sex differences in ischemic stroke outcome

Stroke is the second leading cause of death and a major cause of disability worldwide, and biological sex is an important determining factor in stroke incidence and pathology. From childhood through adulthood, men have a higher incidence of stroke compared with women. Abundant research has confirmed the beneficial effects of estrogen in experimental ischemic stroke but genetic factors such as the X-chromosome complement can also play an important role in determining sex differences in stroke. Au...     

Glial regenerative response in the imaginal discs of Drosophila melanogaster

<正>Glial cells play a key role during nervous system development and actively participate in all the cellular processes involved in maintaining its structural robustness and functional plasticity.In response to neuronal damage,glial cells proliferate,migrate to the injured region and change their morphology,function,and behavior     

Gangliosides in nervous system development,regeneration, and pathologies

Gangliosides, sialic acid-containing sphingolipids, are major constituents of neuronal membranes. According to the number of sialic acids and the structure of the oligosaccharide chain, gangliosides can be classified as simple or complex and grouped in different ganglio-series. Hundreds of gangliosides have been identified in vertebrate cells, with different expression patterns during development and related to several physiological processes, especially in the nervous system. While GD3 and its ...     

文献快报(10):青春期发育延迟与10～25岁骨密度低相关

<正>生命早期的骨骼健康会影响日后患骨质疏松症的风险。青春期发育延迟被认为与青春期和成年期的骨密度(BMD)降低、老年期骨质疏松症风险增加相关。英国布里斯托大学Elhakeem教授及其团队近期在JAMA Netw Open杂志上发表了1篇论文,首次探索了青春期发育年龄与生命早期至成年期骨量增长间的关联。研究数据来自英国埃文郡亲子纵向出生队列(ALSPAC),选取出生于1991—1992年的6 389名新生儿,定期评估身高、体重等指标,在10、12、14、16、18和25岁利用     

心室肌脂肪:一个意想不到的远期生存生物标志物?

正目的非增强CT常常观察到心肌脂肪,但对其认识不足,本文旨在探究心肌内脂肪与全因死亡率的关系,无论是否有心肌梗死病史。方法本回顾性队列研究收集了不     

基于实体瘤疗效评价标准1.1版(RECIST1.1)中的体积阈值:肝转移瘤治疗效果评估

正摘要目的根据临床经验确定肝转移瘤的体积阈值,以评估肝转移瘤的治疗效果及其进展,并使其与线性RECIST阈值保持一致。方法选取最初参加多中心临床Ⅲ期试验的     

可疑儿童急性阑尾炎的首选MRI诊断评估

正摘要随着腹部MRI技术的进步,无需静脉注射或口服对比剂即可实现快速、自由呼吸成像。对于疑似阑尾炎,MRI作为首选成像方法尚未有相关研究。目的探讨MRI作为可     

急性和慢性缺血性病变在多脑血管病变中的临床意义

正摘要目的探讨3.0 T MR多区域病变模式(MTLP)中急、慢性缺血性的关系及其病因学,特别是与房颤相关的脑卒中。方法分析1 000多项研究的数据,这是一项连续纳入     

50岁以下Exeter骨水泥型人工髋关节的长期生存率

<正>50岁以下患者人工髋关节翻修率比较高。作者分析了107例50岁以下病例的资料(130髋),平均年龄41. 8岁。随访至少20年,平均22年。翻修术包括:29例臼杯无菌性松动翻修术,3例柄因为骨溶解翻修,1例柄断裂,1例臼杯不稳定,2例感染。没有柄松动。所有组件22年生存率为74. 9%,柄的生存率为96. 3%。因此作者认为,Exeter