远端缺血后适应通过抑制RAGE的表达实现对心肌的保护作用

目的：探讨晚期糖基化终末产物受体（receptor for advanced glycation end products,RAGE）在远端缺血后适应改善心肌缺血再灌注中的作用。方法：将34只8~9周龄C57BL/6J小鼠随机分为6组：假手术组（Sham组）、FPS?ZM1对照组（FZM1组）、缺血再灌注组（IR组）、FPS?ZM1干预组（FZM1+IR组）、远端缺血后适应组（RIPostC+IR组）和FZM1+远端缺血后适应干预组（FZM1+RIPostC+IR组）。通过结扎左冠状动脉,建立小鼠心肌缺血再灌注模型。采用小鼠心超仪检测小鼠左室射血分数（left ventricular ejection fraction,LVEF）和左室缩短分数（left ventricular fractional shortening,LVFS）,运用酶联免疫分析（ELISA）法和蛋白印迹法检测炎症因子白介素6（interleukin 6,IL?6）、核因子（nudear factor,NF)?κB P65蛋白、RAGE蛋白。结果：①与IR组相比,RIPostC能显著增加LVEF（P < 0.01）和LVFS（P < 0.01）。②与IR组相比,RIPostC能显著降低RAGE（P < 0.001）的表达。③与IR组相比,RIPostC能显著减少NF?κB P65（P < 0.001）和IL?6（P < 0.001）的表达。结论：RIPostC对心肌缺血再灌注损伤具有保护作用。该作用可能通过抑制RAGE的表达进而降低炎性反应而实现。     

The influence of disability on suicidal behaviour

Disability has long-term practical and social consequences, and is associated with mental disorders, in particular with depressive disorder. In this paper we investigate disability in relation to suicide attempts. We hypothesised that such attempts would be more common in people with a disability, and that this would be commensurate with the number of practical difficulties. We also hypothesised that the effect of disability on suicidal behaviour would be mediated by depression. Finally we examined whether particular disabilities were more strongly associated with suicide attempts. A random probability sample comprising 7461 respondents were interviewed throughout 2007 for the third national survey of psychiatric morbidity of adults in England. Disability was measured by difficulties in activities of daily living (ADL) and instrumental activities of daily living (IADL). About one in every 150 adults in England had made a suicide attempt in the past 12 months. Those with some form of disability were four times more likely to have attempted suicide after adjusting for significant sociodemographic and socioeconomic correlates: female, not married, not employed, being in debt and having a physical health problem. Difficulty in managing ones financial affairs (budgeting and paying bills) and dealing with paperwork (writing letters and filling in forms) appear to have a greater influence on the likelihood of suicide attempts than difficulties in carrying out personal care, practical or household activities. Helping people with activities with a high cognitive content as well as with more physical activities is an important element in a suicide prevention strategy.