热休克蛋白70大鼠脑弥漫性轴索损伤后神经元保护及修复作用研究

目的探讨大鼠脑弥漫性轴索损伤(diffuseaxonalinjuries,DAI)后不同时期脑皮层组织中热休克蛋白(heatshockproteins,HSP)70的表达,为临床治疗脑损伤寻求有效手段。方法制作大鼠DAI模型,分别在伤后6、24、48、72h,7d以免疫组织化学方法检测大鼠脑皮层成纤维细胞生长因子(bFGF)的表达,分析其含量变化特点。结果DAI后24hHSP表达增加,48h达高峰,7d后仍维持较高水平。结论bFGF在各时间点表达有明显差异,提示其参与脑损伤后神经元保护及修复过程。     

yes or no

用脑过度会导致神经衰弱吗经常听到有患者说:最近事情太多,用脑过度,神经衰弱了……其实,神经衰弱与用脑过度并无关系。神经衰弱是一种大脑神经功能失调造成的精神和身体活动能力减弱的疾病。由于它多见于脑力工作者,因而使有些人产生了神经衰弱是因为用脑"过度"造成的印象。实际上并非如此。如果仔细观察病人的生活经历就会发现,在所谓用脑"过度"的后面却是长期的内心冲突、精神紧张或情绪不悦,正是这些     

TBI大鼠海马糖皮质激素受体表达变化对认知功能的影响

目的 研究创伤性脑损伤(traumatic brain injury,TBI)后大鼠海马区糖皮质激素受体(ghcocorticoid receptor,GR)表达的变化对认知功能的影响.方法 建立大鼠脑损伤模型,应用免疫组化、Western blot和Morris水迷宫检测伤后大鼠海马区GR表达与学习记忆功能的关系.结果伤后4～10 d大鼠海马区GR持续低表达;Morris水迷宫检测伤后大鼠出现认知功能障碍.结论 TBI大鼠海马区GR表达变化与认知功能的障碍改变具有相关性.

Abstract：

Objective To explore the effect of glucocorticoid receptor(GR)expression in rat hippocampus on cognitive function after traumatic brain injury(TBI). Methods The TBI model wag established in rats.Then,immunohistochemistry and Western blot were used to detect the GR expression and evaluate its relation with cognitire dysfunction by Morris water maze. Results Expression of hippocampal GR was down-regulated 4-10 days after TBI.Morris water maze test showed significant impairment of the cognitive function in rats. Conclusion There is correlation between expression change of hippocampal GR and cognitive dysfunction.     

脑室内巨大脑膜瘤1例

脑膜瘤为常见颅内原发肿瘤,仅次于脑胶质瘤,国内外统计脑膜瘤占原发颅内肿瘤19.2%。脑膜瘤可发生于神经系统各个部位,颅内脑膜瘤多数位于大脑凸面邻近矢状窦和大脑镰,约占50%,脑室内脑膜瘤较少见,约占1%～2%[1]。脑室内脑膜瘤发现时多较大,手术完全切除困难,术后反应重。我     

创伤性脑损伤研究瓶颈问题之我见——国家科技奖获奖后的沉思

由费舟教授领衔完成的《颅脑创伤后继发性脑损害发生机理与诊治新技术应用》课题,获得了2010年度国家科技进步二等奖。笔者作为课题团队的成员之一,几无如释重负之感,却有压力倍增之觉。科研成果的推广和普及,一定程度上提高了创伤性脑损伤（Iraumalic brain injury,YTBI）的救治率。但是,由于我国区域辽阔,     

慢性硬膜下血肿钻孔引流术后并发症临床分析

慢性硬膜下血肿（chronicsubduralhematoma,CSDH）为神经外科常见病,颅骨钻孔引流术（burr—holeirrigationanddrainage,BHID）是治疗CSDH常用且有效的方法,但术后并发症却不少见。现将我院1998年1月至2008年4月行BHID术后17例并发症进行回顾性分析,报道如下：     

不明原因视力下降可能是垂体瘤作怪

垂体瘤患者早期症状表现 垂体是机体的一个重要内分泌腺体结构,可分泌多种激素入血,控制和维持全身其他腺体和组织细胞功能.几乎人体全部生命活动的调节都离不开垂体正常功能.垂体瘤,也叫垂体腺瘤,是指垂体内某种细胞过度增生,引起该细胞分泌激素过剩的现象,还可挤压该细胞周围的细胞,造成受挤压细胞激素分泌不足的表现.     

中颅窝蛛网膜囊肿的临床特点及外科治疗

目的 探讨中颅窝蛛网膜囊肿的临床特点及不同术式对其治疗的临床疗效.方法 回顾性分析第四军医大学西京医院神经外科自2001年5月至2008年5月收治的352例中颅窝蛛网膜囊肿患者(占同期收住的颅内占位性病变患者的2.58%)的临床资料、手术方式及预后情况,其中男性发病率明显高于女性(男:女为4.1∶1),以左侧居多(左∶右为3.6∶1),324例行囊肿切除术,28例巨大囊肿行囊肿-腹腔分流术.结果 术后平均随访3个月～3年.头痛就诊患者中75例(58.59%)术后头痛完全消失,41例(32.03%)明显缓解.癫痫发作患者中8例术后发作频率明显减少或程度减轻.行为异常、注意力不集中或学习困难患者中11例术后改善明显.头围增大和颞部局限性隆起就诊者术后头围及局部隆起无明显变化.影像学复查显示囊肿完全消失者46例(13.07%),囊肿部分消失者257例(73.01%),囊肿无明显变化者49例(13.92%).结论 中颅窝蛛网膜囊肿的临床特点为男性、左侧多发,年龄愈小手术效果越好,手术仅部分切除壁层即可;囊肿巨大时行分流手术效果好,分流管以中低压为佳.

Abstract：

Objective o investigate the clinical characteristics of middle cranial fossa arachnoid cyst (MCFAC) and its therapeutic effects with different surgical methods. Methods Three hundred and fifty-two patients with MCFAC (about 2.58% of patients with intracranial space occupying lesion),admitted to our hospital from May 2001 to May 2008, were chosen in out study; their clinical data,surgical approach and prognosis were analyzed retrospectively. The gender ratio of patient with MCFAC adopted resection of arachnoid cyst and arachnoid cyst-peritoneal shunt was performed in 28 patients.Results Follow-up was performed for 3 months to 3 years. The headache completely disappeared in 75 patients (58.59%) and partial remission in 41 (32.03%) after the operation. The frequency and degree of seizures obviously decreased in 8 of the patients with MCFIAC. Eleven patients with dystropy,attention-deficit disorder or difficulty of learning got improvement. The head circumference and local skull eminentia was stable. The cyst disappeared completely in 46 patients (13.07%), partially in 257 (73.01%) and no changes in 49 (13.92%). Conclusion The clinical features of MCFAC is that it mainly occur in the left side of male. The younger the patient with MCFAC is, the better the treatment effect in the surgical intervention is. good outcome can be achieved by resection of the parietal layer of arachnoid cysts. The indication of shunt with meso-low pressure shunt system is for larger arachnoid cyst.