辨证论治在不孕症中的应用

<正>辨证是认识、诊断疾病的基本手段。是对机体在疾病发展过程中某一阶段病理反映的概括,包括病变的部位、原因、性质以及邪正关系,反映这一阶段病理变化的本质。根据辨证的结果,确定相应的治疗方法是论治。辨证论治的过程,就是认识疾病和解决疾病的过程,是理法方药在临床上的具体运用,是指导中医临床的基本原则。     

幽门螺杆菌的免疫原,实验动物模型及疫苗研究进展

自从Warren等1983年分离出幽门螺杆菌（Helicobacterpylori，Hp）以来．大量研究结果证实Hp是慢性胃炎和消化性溃疡的重要病原体[1,2,3]。由于慢性胃炎可发展为粘膜萎缩、肠化、异型增生．最终导致胃癌，故世界卫生组织已将Hp列为与胃癌发病有关的病原体（Gradelcarcinogen）[4]。一些调查资料表明人类Hp的感染率可达40～60％，Hp疫苗有希望在上述疾病的防治上发挥重要作用。本文对Hp的免疫原、动物模型及疫苗研究进展作一简要介绍。一、免疫原（一）全细胞或超声抗原：Cinn等（1991，1993）先后用Hp抗原口服免疫小鼠或雪貂，免疫动物…     

高敏C反应蛋白在哮喘小鼠中的表达及其与气道炎症的相关性

目的测定哮喘小鼠中高敏C反应蛋白(hs CRP)的水平及其与气道炎症的相关性,观察气道炎症的抑制对其表达的影响。方法应用鸡卵白蛋白(OVA)致敏激发制备哮喘小鼠,测定哮喘小鼠血清、支气管肺泡灌洗液(BALF)中hs CRP水平,分析其与气道高反应性(AHR)、气道嗜酸细胞(Eos)和气道黏液分泌的相关性。在哮喘小鼠OVA激发前后分别腹腔注射DXM和anti-CD69m Ab,观察它们对哮喘小鼠气道炎症及hs CRP的影响。结果哮喘小鼠血清hs CRP显著高于正常小鼠(P<0.05),且与AHR、BALF中Eos、气管周围Eos浸润及黏液表达正相关(r分别=0.90、0.99、0.96、0.90,P均<0.05);但BALF中hs CRP未有显著增高。DXM和anti-CD69m Ab均可有效地抑制血清hs CRP的增高和哮喘小鼠的气道炎症(P均<0.05)。结论哮喘小鼠存在以CRP为指标的系统性炎症,且其水平与气道局部炎症正相关,而气道炎症的抑制可有效地抑制系统性炎症。     

Primary tracheobronchial amyloidosis in China: Analysis of 64 cases and a review of literature

Primary tracheobronchial amyloidosis (TBA) is a rare pulmonary disease.A systematic review was performed on 64 cases of primary TBA in China and progress in the diagnosis and treatment of this disease is discussed.The Chinese biological and medical databases from 1970 to 2010 were searched and 75 cases of complete clinical and pathological data were identified.The clinical characteristics of the disease were summarized and longitudinal comparisons were made of diagnostic and treatment methods over time.The results showed that the morbidity associated with primary TBA has increased over recent years.The clinical manifestations were non-specific.Progressive dyspnea, cough and sputum were the most common symptoms.The percentage of patients undergoing computed tomography (CT) scan has increased over the years.The bronchoscopy and transbrochial lung biopsy (TBLB) were usually sufficient to establish the diagnosis.Treatment was reported for a total of 44 cases.Bronchoscopic Nd:YAG laser irradiation, argon plasma coagulation (APC) and drugs administration such as steroids and colchicines were reported to be effective in some patients.It is concluded that the demographic characteristics and clinical manifestations of primary TBA patients in China are largely consistent with findings reported in other countries.Dramatically more cases were reported in recent years, mainly due to the extensive application of bronchoscopy since 1990s.Chest CT scan provides important clues for the diagnosis of the disease.The definite diagnosis was confirmed by bronchoscopic findings and Congo red staining of biopsy specimen.Bronchoscopic Nd:YAG laser irradiation, argon plasma coagulation (APC) and drugs administration, such as steroids and colchicines were reported to be effective in some patients.     

长期甲氨蝶呤服用致肺非霍奇金淋巴瘤1例

国外文献报道:长期服用甲氨蝶呤与淋巴瘤存在一定关联[1].现报道1例. 临床资料:患者,女性,65岁,因咳嗽气急2个月,右胸痛6 d于2008年8月入院.既往有RA病史22年,11年前开始服用MTX 7.5 mg qw至今.     

肺泡蛋白沉积症的影像学表现

肺泡蛋白沉积症(pulmonary alveolar proteinosis,PAP)是以肺泡中大量不定形的过碘酸雪夫(periodic acidi schiff,PAS)染色阳性的蛋白质类物质沉积为特征的少见肺部疾病,其病因与发病机制仍未明确.现将我院2000～2003年收治的临床资料完整并经病理学检查证实和经全肺灌洗治疗的5例PAP患者的X线平片及CT表现作一回顾性分析,以提高对本病的影像学认识.     

中心静脉导管胸腔闭式引流治疗慢性阻塞性肺病合并自发性气胸的疗效观察

目的:观察和评价中心静脉导管胸腔闭式引流治疗慢性阻塞性肺病(COPD)合并自发性气胸患者的临床疗效.方法:将42例慢性阻塞性肺疾病合并自发性气胸患者随机分为中心静脉导管组22例与粗硅胶导管组20例,常规治疗基础上中心静脉导管组应用中心静脉导管加持续负压吸引行胸腔闭式引流治疗,粗硅胶导管组应用粗硅胶导管治疗,比较两组临床疗效及不良反应.结果:中心静脉导管组有效率90.9%,肺复张时间(4.0±2.2)d,粗硅胶导管组有效率95%,肺复张时间(4.5±1.8)d,两组比较疗效相近,无显著意义(P>0.05);但中心静脉导管组不良反应如胸膜反应、切口感染、皮下气肿、胸痛、血胸等发生率低于粗硅胶导管组,有显著性意义(P<0.05).结论:中心静脉导管胸腔闭式引流治疗COPD合并自发性气胸患者疗效好,安全性高,并发症少.     

先天性左肺未发育伴右乳腺癌一例

患者女,30岁,农民.因"右乳肿块术后15 d"于2005年6月15日入院.患者于15 d前无意中发现右乳肿块,在当地医院就诊,考虑为良性肿瘤,行右乳肿块局部切除术(具体肿块大小、性质不详),术后病理报告:右乳浸润性导管癌.为进一步行右乳腺癌改良根治术来我院.     

迎春还要防感冒

感冒多发于气候骤然转变的冬春季节,在冬天即将结束之时,有时一次降温,人群中就出现一批感冒患者,特别是儿童和老年人。积极预防和减少感冒的发生非常重要,因为感冒是许多疾病的重要致病因素,又是其它疾病病情加重的重要诱因。俗语中的感冒其实是一种上呼吸道急性炎症,它往往由多种病毒(鼻病毒、冠状病毒、流感病毒等)感染而引起的,一年四季均可发病,尤以冬、春季较为多见。主要表现为受冷后出现鼻塞、流涕、咳嗽、咽痛、打喷嚏,重者还有畏寒发热、头痛、全身酸痛等症     

Pulmonary alveolar microlithiasis:report of four familial cases

Pulmonaryalveolarmicrolithiasis (PAM )isararedisease Therehavebeenonlyabout 4 0 0casesreportedinternationallysinceitwasfirstdescribedbyFeidirchin185 6 1　PAMhasfamilialtendency ,buttherearefewreportsoffourcasesinonefamily CASEREPORTSInthisfamily ,thedeceasedgrandparentsandparentshaveallconsanguineouslymarried Themotheris 72yearsoldandhealthywithoutabnormalX raymanifestations Thefatherhasbeendeadformanyyearswithoutcasehistoryhavingeverbeentaken Theyhavesixchildren .Andthreesufferfrom…