全文获取类型
收费全文 | 137篇 |
免费 | 4篇 |
国内免费 | 2篇 |
专业分类
基础医学 | 2篇 |
临床医学 | 48篇 |
内科学 | 62篇 |
综合类 | 16篇 |
预防医学 | 5篇 |
药学 | 8篇 |
1篇 | |
中国医学 | 1篇 |
出版年
2023年 | 4篇 |
2022年 | 1篇 |
2021年 | 1篇 |
2020年 | 4篇 |
2019年 | 3篇 |
2018年 | 4篇 |
2016年 | 2篇 |
2015年 | 2篇 |
2014年 | 3篇 |
2013年 | 7篇 |
2012年 | 9篇 |
2011年 | 7篇 |
2010年 | 4篇 |
2009年 | 8篇 |
2008年 | 8篇 |
2007年 | 9篇 |
2006年 | 4篇 |
2005年 | 8篇 |
2004年 | 8篇 |
2003年 | 5篇 |
2002年 | 8篇 |
2001年 | 6篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1998年 | 3篇 |
1997年 | 11篇 |
1996年 | 6篇 |
排序方式: 共有143条查询结果,搜索用时 31 毫秒
1.
目的:本文采用超声心动图彩色多普勒组织成像(DTI)新技术对6条开胸犬正常心脏运动进行研究。方法:通过用速度、加速度显示方式分析心脏各标准切面的室壁运动。结果:发现,DTI能对心脏各室壁节段的运动作出正确的彩色编码,心脏各节段及心肌各层运动速度并非一致,左室后壁的运动速度高于前壁及前间隔的运动速度,室间隔左室面高于右室面,以左室后壁心内膜面运动速度最高,反映了心肌各节段的收缩能力的不一致性,这种不一致性也可能与心肌纤维特殊的排列方式有关。结论:因此在分析室壁运动时,尤其是定量分析时,应考虑到室壁运动的这种差异。从加速度显示方式分析,能够直视心肌传导上的差异,再现心肌激动的顺序,与心肌传导的电生理研究结果基本相符,为今后评价心脏传导系统的疾病提供客观的依据。 相似文献
2.
4.
5.
目的观察芪苈强心提取物对缺氧诱导的大鼠心肌微血管内皮细胞VEGF及其上游调控因子HIF-1α表达的影响,探讨芪苈强心胶囊抗心力衰竭作用的相关机制。方法植块法培养2周龄SD大鼠心肌微血管内皮细胞并鉴定,传代后将第二代细胞随机分为三组:空白对照组,缺氧干预组,缺氧干预+芪苈强心组。干预6h后收集细胞上清,提取细胞核蛋白及胞浆蛋白,利用ELISA,WesternBlot分别检测细胞上清液中VEGF含量及细胞内VEGF上游调控因子HIF-1α的表达。结果与对照组比较,缺氧干预组心肌微血管内皮细胞VEGF、HIF-1α表达增加,与缺氧干预组比较,芪苈强心干预组VEGF含量均进一步升高,HIF-1α也表现出相同趋势。结论芪苈强心提取物能够通过促进缺氧状态下心肌微血管内皮细胞HIF-1α诱导的VEGF表达,这可能是芪苈强心发挥抗心力衰竭作用的机制之一。 相似文献
6.
血管紧张素Ⅱ受体阻滞剂在慢性心力衰竭治疗中的新地位 总被引:7,自引:0,他引:7
慢性心力衰竭(CHF)是各种心血管疾病发展的终末阶段,有很高的死亡率和致残率。在CHF的发生和发展过程中,肾素-血管紧张素-醛固酮系统(RAS)的激活发挥着重要的作用。RAS的作用主要通过血管紧张素Ⅱ(AngⅡ)来实现。阻断RAS的药物,如血管紧张素转化酶抑制剂(ACEI)抑制AngⅠ向AngⅡ的转化,已证明可以减少CHF的病残率和死亡率。理论上,阻断AngⅡ1型(AT。)受体的药物AngⅡ受体阻滞剂(ARB)可以更完全的阻断RAS,从而发挥对CHF的治疗作用。近来大型临床研究不断完善ARB治疗CHF的证据,使ARB在CHF治疗中的地位得到了进一步提高。 相似文献
7.
Objective To assess the effect of atrial fibriUation (AF) on plasma levels of NT-proBNP in patients with different cardiac functions. Methods One hundred and ninty-one patients with chronic heart failure (CHF) were divided into two groups: minor CHF group (NYHA Ⅰ/Ⅱ class) and sever CHF group (NYHA Ⅲ/Ⅳ class). In addition,84 patients without HF (non-HF group) were enrolled as control The plas-ma NT-proBNP were assayed and the effect of AF on the NT-proBNP levels was analyzed to determine inde-pendent of NT-proBNP levels in 3 groups. Results Patients with AF in non-HF had higher NT-proBNP levels than those with sinus rhythm (SR) [(2.95 ±0.41) vs (2.21±0.44) ng/L, P < 0.01], and multi-variables regression demonstrated that age, AF and left atrial diameter (LAD) were independent determinants of NT-proBNP levels (P <0.001). NT-proBNP levels in minor CHF were also higher in patients with AF than that in patients with SR [(3.26±0.40) ng/L vs (2.98±0.54) ng/L, P < 0.05] ; AF, LAD, left ventricular end-systolic dimension (LVESD) and left vontric-ular eject fraction (LVEF) were the independent factors of NT-proBNP levels (P < 0.05). However, there was no difference of NT-proBNP levels between patients with AF and patients with SR [(3.59±0.52) ng/L vs (3.56±0.55) ng/L,P =0.73] ; while age and LVEF were in-dependent factors (P < 0.05). In patients with LVEF < 0.40, AF had not significant affect on NT-proBNP lev-els [AF vs SR: (3.70±0.60) ng/L vs (3.46±0.56) ng/L,P >0.10]; however,AF patients with LVEF≥ 0.40, NT-proBNP levels were increased [AF vs SR: (3.08 ±0.57) ng/L vs (2.67±0.73) ng/L, P < 0.001]. Conclusion The effect of AF on plasma NT-proBNP was related with cardiac functions: in AF pa-tients without or with minor cardiac dysfunction (NYHA Ⅰ /Ⅱ class or LVEF≥0.40) ,NT-proBNP increased; in AF patients with sever cardiac dysfunction (NYHA Ⅲ/Ⅳ class or LVEF < 0.40), NT-proBNP had no sig-nificant changes. 相似文献
8.
芪苈强心胶囊属于通过中医理论研制而成的中成药,用于慢性充血性心力衰竭,增加心肌收缩力、心输出量和肾血流量,具有一定的临床疗效。但其治疗心力衰竭、抑制心脏重构的具体机制并不是十分清楚。本研究结合近年来国内外相关文献,就中药复方芪苈强心胶囊治疗心力衰竭的相关机制作一简单综述。 相似文献
9.
Objective The relationships between different anticoagulation methods during radiofre-quency catheter ablation(RFCA) of persistent/permanent atrial fibrillation (AF)and thromboembolic events in our center were evaluated. Methods From July 2004 to October 2007, RFCA was consecutively performed in 145 persistent/permanent AF patients. Anticoagulation with warfarin was administrated in all patients before op-eration for at least 1 month, with the international normalized ratio(INR) maintained between 2.0 and 3.0. Be-fore procedure,warfarin was discontinued and replaced by low molecular weight heparin(LMWH). After atrial septum puncture,a total of 5000 U tmfractioned heparin(UFH) were given to patients of group Ⅰ who under-went the ablation from July 2004 to January 2006,while patients of group Ⅱ who underwent the ablation from February 2006 to October 2007 were heparinized(100 U/Kg) according to their weights. During operation, 1000 U UFH was appended per hour. After procedure, LMWH was used for 3 days while warfarin was initiated at the same time and continued for at least 3 months. Results Four patients in group Ⅰ (64 patients ,51 men)experi-enced thrombosis or embolism during or after ablation. One female persistent AF patient in the group Ⅱ (81 pa-tients,67 men)who didn' t fulfill the anticoagulatian therapy experienced TIA after ablation. No thrombeembolic event was identified in other patients of group Ⅱ who fulfilled the anticoagulation therapy. The incidence of thromboembolic event of persistent/permanent AF patients who fulfilled the anticoagulation therapy in the group Ⅱwas lower than that of group Ⅰ (4/64 vs. 0/80, P = 0.037). Conclusions Strengthen the anticoagulation therapy according to patients' weights during radiofrequency ablation could significantly decrease the incidence of thromboembolic event in patients with persistent/permanent AF. 相似文献
10.
冠脉慢性闭塞病变再通对心脏功能的影响 总被引:2,自引:0,他引:2
目的:评价冠脉慢性闭塞病变再通对患者心功能的影响。方法:对冠脉造影证实的冠脉≥1支慢性闭塞的35例患者,采用冠脉介入治疗(PCI:PTCA加支架植入术)或冠脉旁路移植术(CABG),使再血管化,比较治疗前和治疗后3~6个月患者的临床心功能状态和左室射血分数(LVEF)的改变。结果:22例患者行PCI治疗,13例患者行CABG。平均随访4.2个月。治疗后临床心功能状态改善2级以上者27例(77.1%),改善1级者6例(17.1%),无改善者2例(5.8%),总有效率94.2%。LVEF较术前显著改善(术前51.6%±5.8%,术后62.2%±11.3%,P<0.01)。结论:PCI和CABG开通慢性闭塞冠脉能够改善患者的心功能和LVEF。 相似文献