慢性阻塞性肺疾病稳定期从气论治

慢性阻塞性肺疾病是一种具有气流受限特征的疾病,气流受限不完全可逆,呈进行性发展.目前西医治疗只能改善肺功能,不能阻止气道阻塞的进展和气道重塑.近年来运用传统中医药治疗COPD取得显著成效,尤其是对稳定期,能够阻止病情进展、改善肺功能、增强机体免疫力、改善气道高反应性和气道重塑,预防和治疗并发症等.     

Carboxymethylpachymaran enhances immunologic function of dendritic cells cultured in two kinds of hepatoma carcinoma cell line’s supernatant via nuclear factor κB/Rel pathway

Objective:To study the immunologic function of dendritic cells(DCs) cultured in two kinds of hepatoma cell line’s supernatant and the enhancing effects of carboxymethylpachymaran(CMP) on DCs.Methods:DCs were harvested after stimulation by granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin(IL)-4 from umbilical cord blood using density-gradient centrifugation method. Cultured supernatant of two hepatoma cell lines(HepG2 and HepG2.2.15) were collected for condition medium(CM) according to a volume ratio of supernatant to incomplete RPMI-1640 medium,which was 3:1.CMP was dissolved in incomplete RPMI-1640 medium.Experimental groups were divided according to the culture medium,either CM or with CMP in it.DCs subsets CD83,CD86,CD1a,and d-related human leukocyte antigens(HLA-DR) were analyzed by flow cytometry.The proliferation ability of allogeneic T cells in mixed lymphocyte reaction(MLR) stimulated by DCs was examined by 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide(MTT) analysis.IL-12p70,interferon-γ(IFN-γ),and nuclear factor k B(NF- k B) were detected by enzyme-linked immunosorbent assay analysis.Results:The proliferation of lymphocytes and secreting level of IL-12 and expression of phenotype of DCs cultured in two kinds of CM were lower than those of normal group(P<0.01).Compared with the normal group,groups treated with CMP showed a higher expression level of DCs subsets,lymphocyte reproductive activity,as well as IL-12 and IFN-γsecretion levels.Groups treated with CMP also demonstrated higher levels of DCs phenotype expression and IL-12 and IFN-γsecretion in supernatant of MLR and higher lymphocyte reproductive activity compared with CM group(P<0.05).Compared with the normal group,the expression level of NF-k B in DCs nuclear was higher in CMP groups but lower in two CM groups(P<0.05).After CMP was added,the NF-κB expression levels of two CM groups were increased compared with levels before CMP was added(P<0.05).However,there was no significant difference between the two CM groups(P>0.05).Conclusions:Two kinds of hepatoma cell line’s supernatant can inhibit the immunologic function of DCs.This suppressive effect may be related to the inhibition of NF-κB/Rel pathway.CMP may up-regulate the DCs function by activating the NF-κB/Rel pathway.     

参苓白术散加减治疗脾胃虚弱型功能性腹泻的疗效及对肠道菌群的影响

目的：探讨脾胃虚弱型功能性腹泻患者应用参苓白术散加减治疗的疗效及肠道菌群的变化。方法：选择2019年2月~2021年1月收治的60例功能性腹泻患者,采用随机数字表法分对照组和观察组,各30例。对照组予以西医常规治疗,观察组在对照组基础上采用参苓白术散加减治疗。对比两组临床疗效、肠道菌群及不良反应发生情况。结果：治疗后,观察组临床治疗总有效率为93.33%,高于对照组的73.33%,双歧杆菌、乳酸杆菌高于对照组,大肠杆菌低于对照组,差异有统计学意义（P＜0.05）,治疗期间两组均未见明显不良反应。结论：脾胃虚弱型功能性腹泻患者应用参苓白术散加减治疗效果较佳,且能调节肠道菌群,是一种安全、有效的治疗方案,利于患者预后。     

超声引导下细针穿刺抽吸活检对不同大小甲状腺结节的诊断价值

目的:探讨超声引导下细针穿刺抽吸活检(US–FNAB)对不同大小甲状腺结节的诊断价值。方法:选取郑州市中医院2015年1月至2017年1月接受超声引导下细针穿刺抽吸活检患者100例作为研究对象,均在超声引导下行细针穿刺抽吸活检,并经手术治疗及病理诊断。结果:100例患者取材成功率为97%;甲状腺结节诊断敏感性、特异度以及准确率比较:10 mm以下结节,11～20 mm,21～30 mm,30 mm以上。结论:超声引导下细针穿刺抽吸活检,在不同大小甲状腺结节诊断中均有较高准确性。     

浅谈"六气"对预防中风病的基础作用

通过探讨六气与中风病的关系,从人体精微物质的角度,分析了中风病的发病机制,并着重指出六气在中风病发病中的基础作用,从而强调预防中风病以六气为本的概念和治未病的重要思想.     

柴芍承气汤联合芒硝佐治重症急性胰腺炎合并肠麻痹30例

目的:探讨柴芍承气汤配合芒硝治疗重症急性胰腺炎合并肠麻痹的临床疗效.方法:选取我院2014年1月-2016年8月收治的重症急性胰腺炎合并肠麻痹患者60例,随机分为两组,每组各30例,对照组采用常规对症治疗,观察组在常规治疗基础上加服柴芍承气汤联合外敷芒硝袋治疗.结果:观察组的白细胞计数、血清IL-6含量、腹痛消失时间、肛门排气排便时间、血清淀粉酶恢复时间均优于对照组(P＜0.05);观察组总有效率高于对照组(P＜0.05);观察组并发症发生率低于对照组(P＜0.05).结论:重症急性胰腺炎合并肠麻痹患者配合柴芍承气汤联合芒硝外敷治疗临床效果显著.     

四联疗法根治幽门螺杆菌在消化性溃疡活动期与瘢痕期的疗效对比观察

目的：观察四联疗法根治幽门螺杆菌在消化性溃疡活动期与瘢痕期的疗效对比。方法选取2010年5月-2013年5月期间我院收治的消化性溃疡活动期患者69例作为A组,并选择同期收治的消化性溃疡瘢痕期患者64例作为B组,两组患者均以埃索美拉唑肠溶片＋克拉霉素片＋阿莫西林片＋枸橼酸铋钾胶囊四联根治幽门螺杆菌（Hp）。结果 A组共检出Hp阴性64例（92.75%）,Hp阳性5例（7.25%）;而B组结束治疗后检出Hp阴性51例（79.69%）,阳性13例（20.31%）。两组根治率及Hp阳性率均有显著差异（P〈0.01）。结论四联疗法治疗活动期消化性溃疡效果理想,而瘢痕期治疗效果较差。     

加强企业应收帐款管理的相关思考

企业为了生存和发展,千方百计地开展促销活动,扩大自己产品的销售规模和市场的占有份额,其中赊销作为企业促销产品的重要手段之一.但是,赊销也使企业的应收帐款金额迅速庞大,加上企业间相互拖欠货款的现象日益严重,使企业应收帐款金额增长更快,坏帐损失也日益增多,给企业的正常生产经营活动造成严重影响,严重制约了企业的正常生产和发展.如何科学合理的运用好赊销政策、管理好应收账款,是所有企业面临的实际问题.企业为争夺市场,除了要提高产品和服务质量外,还要放宽一定的赊销政策,这对于存在严重应收账款问题的企业,又是一项很艰巨的考验.本文从应收账款坏账的原因着手,得出了全面核算应收帐款的成本,制定科学合理的应收帐款信用政策,加强对应收帐款的监督管理三大策略.