An experimental study of intravascular stent in abdominal aorta of atherosclerotic miniature pigs.

To study the effects of nitinol alloy stent in the treatment of atherosclerotic arterial stenosis, eight miniature pigs were subject to abdominal aortic balloon denudation and high-fatty food. Then 8 nitinol alloy stents were implanted into each abdominal aortas of pigs. The pigs were equally divided into two groups. One group was given captopril (3 mg / kg / d). All animals were sacrified) for pathological examination 6 to 10 months after stent implantation. The degree of arterial intima proliferation in the areas of stent implantation not significantly different from that of areas of balloon denudation alone; the atherosclerotic lesions were found at the arterial surface of stent implantation sites. The intima layer was rich in smooth muscle cells, with atherosclerotic plaque formed around the stent wire. On the other hand, significant decrease in arterial intima proliferation was found in group Ⅱ with no atherosclerotic plaque. The arterial stenosis resulting from atherosclerotic lesion could not be     

Experimental study on the occlusion of arterial blood flow by the implantation of nitinol alloy stents.

To evaluate the occlusion of arteries, 6 conic intravaseular endoprosthetic stents of titanium-nickel alloy were implanted transluminally to the right external iliac arteries in 2 normal dogs and 4 normal pigs. The stent was characterized by ductility below 313 K (40℃) and restoration memory-shape between 313-319 K. The diameter of the large end of conic stent was 4.0 mm (dog) and 4.5 mm(pig). The topographic anatomy showed that the external iliac artery was near complete occlusion, with a very small residual lumen (about 1 mm in diameter) in dogs at 6 months, with complete occlusion in pigs at 8 months. The histopathological examination indicated that the arterial intima of the upper branch from the stented site was smooth, and that neither inflammatory cell infiltration nor foreign giant cell reaction was found. The newly formed granulation tissue inside the stent came from emboli organization. These results suggest that the shape-memory alloy stent has good biocompatibility and the conic intravascnla     

载脂蛋白（a）基因TTTTA五核昔酸重复序列多态性的分析及与血清脂蛋白（a）水平的关系

目的：探讨南京地区汉族人群中载脂蛋白(a)基因TTTTA五核苷酸重复序列多态性及与血清脂蛋白(a)水平的关系。方法：采用PCR、变性聚丙烯酰胺凝胶电泳和溴乙锭染色等技术分析南京地区156例正常汉人TTTTA五核苷酸重复序列。结果：共检出TTTTA串联次数为5、7、8、9、10和11共6种等位基因和5／9、5／8、7／10、8／8、8／9、8／10、9／9、9／10、9／11、11／11的10种基因型，8等位基因频率在南京地区汉族人群中最高，9及5次之。5等位基因(5／9 5／8)血清脂蛋白(a)水平高于8(8／8)、9(8／9 9／9)，但未见有统计学差别。结论：中国汉族南京地区人群存在载脂蛋白(a)基因TTTTA五核苷酸重复序列多态性；未能发现载脂蛋白(a)基因型血清脂蛋白(a)水平的差别。     

β受体阻滞剂治疗心肌梗塞后室性心律失常疗效的初步评估

31例心肌梗塞（MI）后伴室性心律失常（VA）患者，采用美托洛尔单剂口服试验，结果阴性（可耐受用药）24例（77％）；再采用动态心电图作急性药物试验（ADT），达有效标准19例（79％）；有效者继续眼药平均5．2±2．4个月，结果ADT和长程用药疗效相关性为82％。ADT预测长程用药效果良好。提示MI伴VA者应用β受体阻滞剂有效，单剂口服试验和ADT可用来筛选适用美托洛尔的患者。     

吸痰对严重吸入性损伤的治疗作用

吸入性损伤是烧伤病人死亡的主要原因,我们自1995年12月至1999年9月对25例重度吸入性损伤病人的吸痰效果进行分析,并探讨对治疗吸入性损伤的重要作用。临床资料1 一般资料：本组25例,男16例,女9例,年龄7岁-58岁,平均32.5±7.5岁,烧伤面积22%-30% 1例,31%-50% 4例,>51% 20例。火焰烧伤18例(其中16例在密闭的室内、车内或船仓内因火焰烟雾伤),热水泥粉尘吸入伤2例,热液烫伤4例,(其中3例热蒸气吸入伤)电烧伤1例。23例经纤维支气管镜检查,较客观的诊断为重度吸入性损伤(2例小孩未经纤维支气管镜检查),镜下见气管支气管粘膜有不同…     

放射治疗实施过程中的质量保证及质量控制

文章介绍了放射治疗师实施放疗计划的质控经验.     

cyclinD1和CDK4在低氧心肌中的表达及意义

目的研究低氧心肌细胞周期及缺氧过程中细胞周期蛋白D1(cyclinD1)和细胞周期蛋白依赖激酶4(CDK4)表达的变化,探讨缺氧心肌在凋亡前是否存在增殖能力和自身修复。方法采用SD大鼠乳鼠进行心肌细胞培养,建立心肌缺血模型,实验分正常对照、缺血6 h和缺血12 h三组;以四唑盐比色试验(MTT)检测心肌细胞活力,流式细胞术测定细胞周期,免疫组化检测cyclinD1和CDK4表达。结果与对照组比较,心肌细胞缺氧处理6 h后,细胞周期中S 期比例增高(P<0 01),12 h后,S期比例下降(P<0 05);cyclinD1胞浆表达和CDK4 胞核表达增加。结论在缺氧所致死亡、凋亡过程中心肌细胞经历了一定程度的增殖过程,cyclinD1 和CDK4 表达增加参与了细胞增殖,缺氧损伤可刺激心肌细胞增殖能力。     

<江苏医药>改版寄语

今年是《江苏医药》的而立之年,在她成长和发展的过程中得到省内外医药界同仁和卫生管理部门各级领导的关爱和帮助,对此,我们致以深深的谢意。今年又是《江苏医药》深化改革和尝试改版的一年,在她向新的更高的目标奋力迈进之际,我们期望着能够得到大家更多的理解和支持。     

充血性心力衰竭、急性心肌梗塞患者血淋巴细胞β-受体的改变及其临床意义

本文对12例充血性心力衰竭(CHF)及5例急性心肌梗塞(AMI)患者血淋巴细胞β-受体进行测定,结果表明:CHF 患者血中淋巴细胞β-受体密度较正常对照降低21.2%,亲和力无改变;AMI 早期,患者淋巴细胞β-受体密度和平衡解离常数均高于正常。提示淋巴细胞β-受体可反映心肌β-受体的状况,从而可能有助手心血管疾病的诊断和治疗。     

应用二维超声方法评价高血压血管内皮功能

目的:对高血压1～2级无心血管其他危险因素病人的血管内皮功能作一评估,并探讨高血压对内皮功能的影响及其可能机制。方法:研究对象30例,高血压病人和正常人各15例。应用高分辨二维超声方法检测反应性充血前后肱动脉直径,比较两组的血流介导血管舒张测定百分数(FMD)功能以及与血压之间的关系;同时比较两组血清氧化低密度脂蛋白(ox-LDL)、一氧化氮(NO)及内皮素-1(ET-1)的水平。结果:①高血压病人FMD(10.79%)明显低于对照组(19.61%),P<0.01。②相关分析显示,FMD%分别与收缩压(r=-0.446,P<0.01)、舒张压(r=-0.645,P<0.01)呈负相关。③高血压病人血清ox-LDL、ET-1显著高于对照组(P<0.01),而NO则明显低于对照组(P<0.01)。结论:高血压病早期虽无明显动脉硬化,但已存在血管内皮功能的损伤。