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《Neuro-Chirurgie》2023,69(5):101479
ObjectiveThis study aimed to evaluate short-term clinical efficacy of percutaneous endoscopic posterior lumbar interbody fusion (Endo-LIF) in the treatment of obese patients with lumbar degenerative diseases (LDD).MethodsPatients who underwent single-level lumbar fusion surgery from July 2020 to July 2022 were retrospectively analyzed in this study. The main inclusion criterion was a body mass index (BMI) ≥30 kg/m2. A matched case-control design was conducted to compare the short-term outcomes between the Endo-LIF and transforaminal lumbar interbody fusion (TLIF) in obese patients. Cases were defined as those who underwent Endo-LIF, and controls were matched from those patients with open TLIF according to corresponding matched criteria. Surgeon satisfaction was evaluated by questionnaires at the end of each surgery, patient satisfaction and their willingness to undergo the same surgery again were collected.ResultsTwo groups of patients were successfully completed surgery. In comparison with the open TLIF group, the Endo-LIF group had significantly less blood loss, less time to postoperative ambulation, less postoperative complications and shorter hospitalization days, but longer operation time and x-ray exposure times. The satisfaction of surgeons and patients in Endo-LIF group significantly were superior to open TLIF group.ConclusionEndo-LIF is a safe and effective surgery in the treatment of obese patients. Although this procedure needs longer operation time and x-ray exposure times, it still maybe a promising option for obese patients with LDD.  相似文献   
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DNA损伤是衰老相关疾病领域的研究热点, 可引起细胞周期停滞、凋亡, 加快个体衰老速度、增加衰老相关疾病的患病风险。本文将从细胞衰老和个体衰老两个层面阐述其与衰老之间的研究进展, 并综述其与衰老常见相关疾病(肿瘤、心血管疾病、阿尔茨海默病)及早衰综合征的关系, 为抗衰老研究和临床干预衰老相关疾病提供理论依据。  相似文献   
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Background and aimsHigh-fat diet (HFD) intake during gestation and lactation has been associated with an increased risk of developing cardiometabolic disorders in adult offspring. We investigated whether metabolic alterations resulting from the maternal consumption of HFD are prevented by the addition of omega-3 (?3) in the diet.Methods and resultsWistar rat dams were fed a control (C: 19% of lipids and ?6:?3 = 12), HF (HF: 33% lipids and ?6:?3 = 21), or HF enriched with ?3 (HFω3: 33% lipids and ?6:?3 = 9) diet during gestation and lactation, and their offspring food consumption, murinometric measurements, serum levels of metabolic markers, insulin and pyruvate sensitivity tests were evaluated. The maternal HFD increased body weight at birth, dyslipidemia, and elevated fasting glucose levels in the HF group. The enrichment of ?3 in the maternal HFD led to lower birth weight and improved lipid, glycemic, and transaminase biochemical profile of the HFω3 group until the beginning of adulthood. However, at later adulthood of the offspring, there was no improvement in these biochemical parameters.ConclusionOur findings show the maternal consumption of high-fat ?3-rich diet is able to attenuate or prevent metabolic disruption elicited by HFD in offspring until 90 days old, but not in the long term, as observed at 300 days old of the offspring.  相似文献   
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Background and aimsThere is no prior research on the usefulness that popular nutrition-related mobile applications would have in assessing fatty acids intake. In this study, we examine these applications through their utilization in the assessment of consumption of saturated (SFAs) and polyunsaturated (PUFAs) fatty acids against the Polish reference method (RM, Dieta 6.0). This report does also include the information about monounsaturated fatty acids and cholesterol intake.Methods and resultsSFAs and PUFAs intake was assessed using two-day dietary recalls obtained from 120 individuals by 3 selected mobile applications (App1 = Yazio, App2 = MyFitnessPal, App3 = Fitatu) and compared with RM.Despite strong (SFAs by App1 and App3) and moderate (SFAs by App2 and PUFAs by App1, App2, App3) correlations with RM, Bland-Altman analyses showed relevant biases and wide range between limits of agreement. Considering SFAs and MUFAs intake, App1 had the best agreement. App1 had high sensitivity (94.6%) in recognition of subjects with SFAs intake >10% with moderate specificity (67.9%), while App2 had poor sensitivity (27.2%) and high specificity (100%). App3 showed moderate sensitivity and specificity (77.2% and 75%, respectively).ConclusionsMobile applications are not accurate tools in SFAs and PUFAs assessment when compared to the RM. Nonetheless, their ability to recognize SFAs intake >10% energy intake may suggest that further development of mobile applications could potentially become an attractive tool in clinical practice.  相似文献   
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背景 阿霉素(DOX)是一种常见的强效蒽环类抗肿瘤药物,被广泛应用于各类肿瘤尤其是实体性肿瘤的治疗中。然而,DOX有较强的心脏毒性,临床表现为不可逆性心肌病和充血性心力衰竭。黄酒多酚(YWPC)是从绍兴黄酒中提取的多酚类物质,具有抗炎、抗氧化等生理活性,对DOX所致心肌损伤有一定缓解作用,但其作用机制还不明晰。 目的 通过体内外实验探讨YWPC减轻DOX心肌损伤的作用机制。 方法 动物实验:使用SD大鼠建立DOX心肌损伤模型,分为对照组、YWPC组、DOX组与DOX+YWPC组;取心脏组织进行MASSON染色、原位末端标记(TUNEL)染色及免疫组织化学染色,取血清测定乳酸脱氢酶(LDH)水平,并用动物组织蛋白、Western Blot法检测凋亡水平〔B淋巴细胞瘤-2蛋白(Bcl-2)、Bcl-2相关X蛋白(Bax)〕及沉默调节蛋白3(SIRT3)表达水平变化。体外实验:通过1 μmol/L DOX干预H9C2细胞24 h建立DOX诱导H9C2细胞损伤模型,先将一批H9C2细胞分为对照组、DOX组、DOX+YWPC(1 mg/L)组、DOX+YWPC(10 mg/L)与DOX+YWPC(100 mg/L)5组,采用CCK-8法检测H9C2细胞活力,通过Western Blot法检测凋亡水平及SIRT3表达水平变化;之后将另一批H9C2细胞分为对照组、DOX组、DOX+YWPC组、DOX+SIRT3抑制剂(3-TYP)组及DOX+YWPC+3-TYP组,通过3-TYP抑制SIRT3蛋白活性,通过Western Blot法检测凋亡水平及SIRT3表达水平变化,进一步明确SIRT3在YWPC减轻DOX心肌损伤中的作用。 结果 动物实验中,大鼠心肌切片通过MASSON染色后可见:DOX组大鼠心肌纤维排列紊乱,大量蓝色胶原纤维贯穿心肌纤维;DOX+YWPC组大鼠心肌切片纹理部分恢复,蓝色胶原纤维减少。DOX组胶原纤维占比、血清LDH水平高于对照组、DOX+YWPC组(P<0.05)。DOX组Bcl-2/Bax比值、SIRT3表达水平低于对照组、DOX+YWPC组(P<0.05);DOX组大鼠心肌切片中代表凋亡的绿色亮点明显增多,呈片状分布,而经YWPC治疗后凋亡亮点减少。体外实验中,DOX组吸光度值、Bcl-2/Bax比值、SIRT3表达水平低于对照组、DOX+YWPC(1 mg/L)组、DOX+YWPC(10 mg/L)组、DOX+YWPC(100 mg/L)组(P<0.05),DOX组、DOX+3-TYP组Bcl-2/Bax比值、SIRT3表达水平低于对照组(P<0.05);DOX+YWPC+3-TYP组Bcl-2/Bax比值低于DOX+YWPC组(P<0.05),DOX+YWPC组与DOX+YWPC+3-TYP组SIRT3表达水平比较,差异无统计学意义(P>0.05)。 结论 YWPC可以通过调节SIRT3表达水平减轻DOX心肌损伤,抑制SIRT3会降低YWPC的作用。  相似文献   
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