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采用组化特染,透射电镜和图象分析仪观察了35只正常人眼筛板结缔组织的纤维成分和结构形态,根据生物力学原理分析了筛束的力学性质和筛板的结构特征,探讨了筛板的损害形式和在眼压与视神经损害间的中介作用及其影响因素。结果显示,筛束含有细胞间质所有三种纤维,具有弹性、塑性和刚性三重复合性质,筛板纵向椭圆、筛束行径和密度象限性差异及筛板厚度个体性差异等与筛板抗损害性能有关。眼压对筛板作用有两种途径,筛板损害是 相似文献
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小骨窗前纵裂入路显微手术切除巨大颅咽管瘤(17例报告) 总被引:1,自引:0,他引:1
目的评价小骨窗前纵裂入路在颅咽管瘤手术中的应用价值及并发症。方法经小骨窗前纵裂入路切除巨大颅咽管瘤17例,对手术技术及结果进行总结。结果本组全切除15例、近全切除2例,无手术死亡病例。由于术中直视下处理肿瘤在垂体漏斗部位的粘连,可较好保护垂体柄、下丘脑结构及局部穿支血管,13例患者超过2年的随访未见肿瘤复发及再生长。结论经小骨窗前纵裂入路可直视下处理肿瘤鞍内、鞍上及三脑室前部分,是鞍上生长位置较高的大型颅咽管瘤安全有效的手术入路之一。 相似文献
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IL-10 Secretion and Sensitivity in Normal Human Intestine and Inflammatory Bowel Disease 总被引:13,自引:0,他引:13
Gasche C Bakos S Dejaco C Tillinger W Zakeri S Reinisch W 《Journal of clinical immunology》2000,20(5):362-370
Interleukin-10 (IL-10) deficiency in gene knockout mice causes chronic enterocolitis. We hypothesized that inflammation in human inflammatory bowel disease might result from innate alterations in the IL-10 pathway. Serum, supernatants, and mRNA of peripheral blood mononuclear cells (PBMC) and lamina propria mononuclear cells (LPMC) derived from inflamed (LPMC-i) and noninflamed colonic mucosa (LPMC-ni) were collected from patients with Crohn's colitis, ulcerative colitis, and controls. IL-10 protein concentrations and IL-10 mRNA were examined in response to PMA/CD3 or PHA stimulation. The response to rhIL-10 was assessed by inhibition of tumor necrosis factor-alpha (TNF-), IL-6, and interferon-gamma (IFN-) production. Serum IL-10 levels of inflammatory bowel disease (IBD) patients were within the normal range. IL-10 concentrations in supernatants from LPMC-i were significantly lower than from LPMC-ni or PBMC. No difference was seen between samples from ulcerative colitis and Crohn's disease. IL-10 mRNA was detected in 0/4 LPMC-i samples compared to 1/6 LPMC-ni and 6/6 PBMC. RhIL-10 inhibited TNF-, IL-6, and IFN- synthesis in PBMC. This effect was strongly diminished in LPMC. Disease-specific alterations were not detected. Our data suggest that LPMC derived from inflamed colonic mucosa have a reduced ability to produce and to respond to rhIL-10. A disease-specific alteration in the IL-10 pathway, however, was not found. 相似文献
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Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn's disease 总被引:2,自引:0,他引:2
Maerten P Geboes K De Hertogh G Shen C Cadot P Bullens DM Van Assche G Penninckx F Rutgeerts P Ceuppens JL 《Clinical immunology (Orlando, Fla.)》2004,112(3):239-246
4-1BB ligand (L) expressed on antigen presenting cells (APC) interacts with 4-1BB, expressed on activated T cells and this interaction costimulates T cells to secrete cytokines and to proliferate. We investigated whether 4-1BB/4-1BBL interactions might be involved in the pathogenesis of Crohn's disease (CD). In immunohistochemistry, we found 4-1BB expression on lamina propria (LP) cells in inflamed and to a lesser extend in non-inflamed gut tissue from CD patients. mRNA levels for 4-1BB were also elevated in intestinal CD tissue. In contrast, only few 4-1BB-expressing cells were found in inflamed tissue from ulcerative colitis (UC) patients and almost no positive cells were found in control intestinal tissue. 4-1BB expression was better sustained on in vitro activated lamina propria T cells from CD patients compared to controls. Finally, agonistic anti-4-1BB antibody enhanced interferon-gamma (IFN-gamma) production and proliferation of lamina propria T cells from CD patients. Taken together, our data suggest that 4-1BB/4-1BBL interactions contribute to the persistence of gut inflammation in CD. 相似文献
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采用正常死者眼球和新生血管性青光眼的筛板组织, 研究高眼压对视乳头筛板和结缔组织的作用. 正常眼球12 只, 新生血管性青光眼眼球12 只, 摘除眼球后用10 % 福尔马林溶液固定, 切取视乳头组织约2 m m ×2 mm , 石蜡包埋, 苏木素- 伊红染色, 免疫细胞化学 A B C 法染色. 结果: 正常人筛板的横纵切面具有特定形态, 新生血管性青光眼筛板孔板变形, 筛孔周围结缔组织断裂, 丧失了筛板结构. 结果表明:高眼压下筛孔板和结缔组织的改变, 造成对筛板孔神经纤维的挤压, 阻滞了神经纤维轴浆的运输, 导致神经纤维功能上的损害和相应的视野缺损. 相似文献
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ObjectivesIrritation fibroma in the oral cavity causes atrophy or squamous epithelium thickening with respect to external injury-associated factors. However, ulcers do not occur in most cases. This study aimed to elucidate the mechanism by which ulcers do not form, focusing on the vascular network in the mucosal epithelium of irritation fibroma.MethodsImmunostaining was performed using an enzyme antibody method with primary antibodies against CD31 and Ki-67 in 17 cases of irritation fibroma in the buccal mucosa. One section was taken at three points from the margin and three points from just above the lesion for measurement. The number of blood vessels in the superficial and deep lamina propria at the measurement site were determined, and the area per blood vessel was measured.ResultsThe number and area of blood vessels in the superficial lamina propria just below the lesion epithelium were smaller than those in the margin. No difference was observed in the number and area of blood vessels in the deep lamina propria between the margins and lesions.ConclusionsOur results suggest that the vascular network in the deep lamina propria is maintained and compensates for the nutrient supply to the covering epithelium. 相似文献