全文获取类型
收费全文 | 69348篇 |
免费 | 4229篇 |
国内免费 | 1438篇 |
专业分类
耳鼻咽喉 | 103篇 |
儿科学 | 1830篇 |
妇产科学 | 787篇 |
基础医学 | 4924篇 |
口腔科学 | 519篇 |
临床医学 | 9126篇 |
内科学 | 22616篇 |
皮肤病学 | 172篇 |
神经病学 | 1240篇 |
特种医学 | 1634篇 |
外国民族医学 | 1篇 |
外科学 | 8984篇 |
综合类 | 10514篇 |
预防医学 | 2799篇 |
眼科学 | 93篇 |
药学 | 5959篇 |
47篇 | |
中国医学 | 3050篇 |
肿瘤学 | 617篇 |
出版年
2023年 | 985篇 |
2022年 | 1418篇 |
2021年 | 2402篇 |
2020年 | 2451篇 |
2019年 | 2273篇 |
2018年 | 2271篇 |
2017年 | 1991篇 |
2016年 | 1977篇 |
2015年 | 2219篇 |
2014年 | 4741篇 |
2013年 | 4983篇 |
2012年 | 3768篇 |
2011年 | 4503篇 |
2010年 | 3637篇 |
2009年 | 3667篇 |
2008年 | 3564篇 |
2007年 | 3526篇 |
2006年 | 3244篇 |
2005年 | 2939篇 |
2004年 | 2296篇 |
2003年 | 2022篇 |
2002年 | 1639篇 |
2001年 | 1566篇 |
2000年 | 1209篇 |
1999年 | 1003篇 |
1998年 | 818篇 |
1997年 | 785篇 |
1996年 | 687篇 |
1995年 | 659篇 |
1994年 | 614篇 |
1993年 | 468篇 |
1992年 | 458篇 |
1991年 | 412篇 |
1990年 | 346篇 |
1989年 | 352篇 |
1988年 | 343篇 |
1987年 | 261篇 |
1986年 | 218篇 |
1985年 | 255篇 |
1984年 | 243篇 |
1983年 | 168篇 |
1982年 | 190篇 |
1981年 | 185篇 |
1980年 | 189篇 |
1979年 | 158篇 |
1978年 | 140篇 |
1977年 | 124篇 |
1976年 | 119篇 |
1975年 | 110篇 |
1973年 | 97篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Rolf Svedjeholm Gabriele Ferrari Farkas Vanky Örjan Friberg Jonas Holm 《Acta anaesthesiologica Scandinavica》2023,67(10):1373-1382
Background
Glutamate plays a key role for post-ischaemic recovery of myocardial metabolism. According to post hoc analyses of the two GLUTAMICS trials, patients without diabetes benefit from glutamate with less myocardial dysfunction after coronary artery bypass surgery (CABG). Copeptin reflects activation of the Arginine Vasopressin system and is a reliable marker of heart failure but available studies in cardiac surgery are limited. We investigated whether glutamate infusion is associated with reduced postoperative rises of plasma Copeptin (p-Copeptin) after CABG.Methods
A prespecified randomised double-blind substudy of GLUTAMICS II. Patients had left ventricular ejection fraction ≤0.30 or EuroSCORE II ≥3.0 and underwent CABG ± valve procedure. Intravenous infusion of 0.125 M L-glutamic acid or saline at 1.65 mL/kg/h was commenced 10–20 min before the release of the aortic cross-clamp and then continued for another 150 min P-Copeptin was measured preoperatively and postoperatively on day one (POD1) and day three. The primary endpoint was an increase in p-Copeptin from the preoperative level to POD1. Postoperative stroke ≤24 h and mortality ≤30 days were safety outcomes.Results
We included 181 patients of whom 48% had diabetes. The incidence of postoperative mortality ≤30 days (0% vs. 2.1%; p = .50) and stroke ≤24 h (0% vs. 3.2%; p = .25) did not differ between the glutamate group and controls. P-Copeptin increased postoperatively with the highest values recorded on POD1 without significant inter-group differences. Among patients without diabetes, p-Copeptin did not differ preoperatively but postoperative rise from preoperative level to POD1 was significantly reduced in the glutamate group (73 ± 66 vs. 115 ± 102 pmol/L; p = .02). P-Copeptin was significantly lower in the Glutamate group on POD1 (p = .02) and POD 3 (p = .02).Conclusions
Glutamate did not reduce rises of p-Copeptin significantly after moderate to high-risk CABG. However, glutamate was associated with reduced rises of p-Copeptin among patients without diabetes. These results agree with previous observations suggesting that glutamate mitigates myocardial dysfunction after CABG in patients without diabetes. Given the exploratory nature of these findings, they need to be confirmed in future studies. 相似文献2.
3.
4.
《Enfermería clínica》2022,32(3):171-183
IntroductionAgeing is a period of physical and psychological changes. Inactivity is one of the biggest problems among the older adult population increasing the risk of sarcopenia and chronic diseases. Physical activity is an effective intervention to improve health outcomes. In recent years, there has been an increase in the use of technology, with health technology tools (ICT) appearing as an intervention to increase physical activity and improve associated health problems.ObjectiveIn this review, we evaluated the effectiveness of health technology to increase physical activity and to improve cardiovascular parameters in older adults.MethodologyStudies with a great variety of health technology tools to increase physical activity levels, and that evaluated the effect of that increase on cardiovascular parameters were included by searching the main databases.ResultsEleven studies reporting the use of a variety of ICT tools were included in this review. Despite these differences, the effectiveness of health technology tool interventions has been demonstrated in increasing physical activity and reducing cardiovascular parameters.DiscussionThe lack of adherence of older adults to health technology would be a disadvantage, but it has been shown that younger older adults are more familiar with health technology tools and the number using them is increasing.ConclusionHealth technology tools show effectiveness in increasing physical activity in older adults and improving cardiovascular parameters. 相似文献
5.
6.
7.
8.
9.
10.